PMID- 35576662
OWN - NLM
STAT- MEDLINE
DCOM- 20220608
LR  - 20220608
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 151
DP  - 2022 Jul
TI  - Regulation of the intestinal flora: A potential mechanism of natural medicines in 
      the treatment of type 2 diabetes mellitus.
PG  - 113091
LID - S0753-3322(22)00480-2 [pii]
LID - 10.1016/j.biopha.2022.113091 [doi]
AB  - Diabetes mellitus comprises a group of heterogeneous disorders, which are usually 
      subdivided into type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus 
      (T2DM). Both genetic and environmental factors have been implicated in the onset 
      of diabetes. Type 1 diabetes primarily involves autoimmune insulin deficiency. In 
      comparison, type 2 diabetes is contributed by the pathological state of insulin 
      deficiency and insulin resistance. In recent years, significant differences were 
      found in the abundance of microflora, intestinal barrier, and intestinal 
      metabolites in diabetic subjects when compared to normal subjects. To further 
      understand the relationship between diabetes mellitus and intestinal flora, this 
      paper summarizes the interaction mechanism between diabetes mellitus and 
      intestinal flora. Furthermore, the natural compounds found to treat diabetes 
      through intestinal flora were classified and summarized. This review is expected 
      to provide a valuable resource for the development of new diabetic drugs and the 
      applications of natural compounds.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - He, Liying
AU  - He L
AD  - Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, 
      College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 
      611137, China. Electronic address: heliying@stu.cdutcm.edu.cn.
FAU - Yang, Fang-Qing
AU  - Yang FQ
AD  - Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, 
      College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 
      611137, China. Electronic address: fangqingyang6@163.com.
FAU - Tang, Pan
AU  - Tang P
AD  - Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, 
      College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 
      611137, China. Electronic address: tangpan@stu.cdutcm.edu.cn.
FAU - Gao, Ting-Hui
AU  - Gao TH
AD  - Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, 
      College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 
      611137, China. Electronic address: gaotinghui@stu.cdutcm.edu.cn.
FAU - Yang, Cai-Xia
AU  - Yang CX
AD  - Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, 
      College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 
      611137, China. Electronic address: ycx445813@163.com.
FAU - Tan, Li
AU  - Tan L
AD  - Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, 
      College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 
      611137, China. Electronic address: 2020KS231@stu.cdutcm.edu.cn.
FAU - Yue, Pan
AU  - Yue P
AD  - Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, 
      College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 
      611137, China. Electronic address: yuepan1@stu.cdutcm.edu.cn.
FAU - Hua, Ya-Nan
AU  - Hua YN
AD  - College of Medical Technology, Chengdu University of Traditional Chinese 
      Medicine, Chengdu 611137, China. Electronic address: 18766567027@163.com.
FAU - Liu, Si-Jing
AU  - Liu SJ
AD  - College of Medical Technology, Chengdu University of Traditional Chinese 
      Medicine, Chengdu 611137, China. Electronic address: liusijing@cdutcm.edu.cn.
FAU - Guo, Jin-Lin
AU  - Guo JL
AD  - Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, 
      College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 
      611137, China; College of Medical Technology, Chengdu University of Traditional 
      Chinese Medicine, Chengdu 611137, China. Electronic address: 
      guo596@cdutcm.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220513
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Insulin)
SB  - IM
MH  - *Diabetes Mellitus, Type 1
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - *Gastrointestinal Microbiome
MH  - Humans
MH  - Insulin/therapeutic use
MH  - Intestines
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Intestinal flora
OT  - Natural medicines
OT  - Pathogenesis
OT  - Treatment
EDAT- 2022/05/17 06:00
MHDA- 2022/06/09 06:00
CRDT- 2022/05/16 18:15
PHST- 2022/02/26 00:00 [received]
PHST- 2022/04/24 00:00 [revised]
PHST- 2022/05/04 00:00 [accepted]
PHST- 2022/05/17 06:00 [pubmed]
PHST- 2022/06/09 06:00 [medline]
PHST- 2022/05/16 18:15 [entrez]
AID - S0753-3322(22)00480-2 [pii]
AID - 10.1016/j.biopha.2022.113091 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2022 Jul;151:113091. doi: 10.1016/j.biopha.2022.113091. Epub 
      2022 May 13.