PMID- 35578689
OWN - NLM
STAT- MEDLINE
DCOM- 20220518
LR  - 20220531
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2022
DP  - 2022
TI  - Aerobic Exercise Improves Type 2 Diabetes Mellitus-Related Cognitive Impairment 
      by Inhibiting JAK2/STAT3 and Enhancing AMPK/SIRT1 Pathways in Mice.
PG  - 6010504
LID - 10.1155/2022/6010504 [doi]
LID - 6010504
AB  - Type 2 diabetes mellitus (T2DM) is a prevalent risk factor for cognitive 
      impairment. Aerobic exercise can improve T2DM-related cognitive impairment; 
      however, the possible mechanisms remain elusive. Thus, we assessed db/m mice and 
      leptin receptor-deficient (db/db) mice that did or did not perform aerobic 
      exercise (8 m/min, 60 min/day, and 5 days/week for 12 weeks). In this study, 
      cognitive function was significantly impaired in the T2DM mice; aerobic exercise 
      improved cognitive impairment through activating the AMPK/SIRT1 signalling 
      pathway and inhibiting the JAK2/STAT3 signalling pathway in T2DM mice. However, 
      after the application of RO8191 (JAK2 activator) or Compound C (AMPK inhibitor), 
      the positive improvement of the exercise was evidently suppressed. Taken 
      together, our data indicated that long-term aerobic exercise improves type 2 
      diabetes mellitus-related cognitive impairment by inhibiting JAK2/STAT3 and 
      enhancing AMPK/SIRT1 pathways in mice.
CI  - Copyright (c) 2022 Lili Lin et al.
FAU - Lin, Lili
AU  - Lin L
AUID- ORCID: 0000-0003-4578-5385
AD  - Department of Recovery (Department of Rehabilitation Medicine and Physiotherapy), 
      The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000 
      Zhejiang Province, China.
FAU - Wang, Yonghua
AU  - Wang Y
AUID- ORCID: 0000-0003-1992-3238
AD  - Department of Physical Education, Wenzhou Medical University, Wenzhou 325800 
      Zhejiang Province, China.
FAU - Xu, Wenli
AU  - Xu W
AUID- ORCID: 0000-0001-5727-5214
AD  - Department of Recovery (Department of Rehabilitation Medicine and Physiotherapy), 
      The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000 
      Zhejiang Province, China.
FAU - Huang, Chaolu
AU  - Huang C
AUID- ORCID: 0000-0002-8684-9624
AD  - Department of Recovery (Department of Rehabilitation Medicine and Physiotherapy), 
      The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000 
      Zhejiang Province, China.
FAU - Hu, Jinrong
AU  - Hu J
AUID- ORCID: 0000-0001-7063-0102
AD  - Department of Recovery (Department of Rehabilitation Medicine and Physiotherapy), 
      The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000 
      Zhejiang Province, China.
FAU - Chen, Xixi
AU  - Chen X
AUID- ORCID: 0000-0002-2871-4027
AD  - Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000 Zhejiang Province, China.
FAU - Lv, Xinhuang
AU  - Lv X
AUID- ORCID: 0000-0002-1600-7157
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000 Zhejiang Province, China.
FAU - Qin, Yuelin
AU  - Qin Y
AUID- ORCID: 0000-0002-3247-5540
AD  - Department of Recovery (Department of Rehabilitation Medicine and Physiotherapy), 
      The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000 
      Zhejiang Province, China.
FAU - Zhao, Xiaoyong
AU  - Zhao X
AUID- ORCID: 0000-0002-8088-7451
AD  - Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000 Zhejiang Province, China.
AD  - Department of Anesthesiology, Affiliated Hospital of Weifang Medical University, 
      Weifang 261000, China.
FAU - Li, Haiyan
AU  - Li H
AUID- ORCID: 0000-0001-9051-1063
AD  - Department of Recovery (Department of Rehabilitation Medicine and Physiotherapy), 
      The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000 
      Zhejiang Province, China.
LA  - eng
PT  - Journal Article
DEP - 20220505
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (Stat3 protein, mouse)
RN  - EC 2.7.10.2 (Jak2 protein, mouse)
RN  - EC 2.7.10.2 (Janus Kinase 2)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
RN  - EC 3.5.1.- (Sirt1 protein, mouse)
RN  - EC 3.5.1.- (Sirtuin 1)
SB  - IM
MH  - AMP-Activated Protein Kinases/metabolism
MH  - Animals
MH  - *Cognitive Dysfunction/etiology
MH  - *Diabetes Mellitus, Type 2/complications/metabolism
MH  - Janus Kinase 2/metabolism
MH  - Mice
MH  - *Physical Conditioning, Animal
MH  - STAT3 Transcription Factor/metabolism
MH  - Signal Transduction
MH  - Sirtuin 1/genetics/metabolism
PMC - PMC9107038
COIS- The authors have no relevant financial or nonfinancial interests to disclose.
EDAT- 2022/05/18 06:00
MHDA- 2022/05/19 06:00
PMCR- 2022/05/05
CRDT- 2022/05/17 01:47
PHST- 2022/02/21 00:00 [received]
PHST- 2022/04/06 00:00 [revised]
PHST- 2022/04/16 00:00 [accepted]
PHST- 2022/05/17 01:47 [entrez]
PHST- 2022/05/18 06:00 [pubmed]
PHST- 2022/05/19 06:00 [medline]
PHST- 2022/05/05 00:00 [pmc-release]
AID - 10.1155/2022/6010504 [doi]
PST - epublish
SO  - Dis Markers. 2022 May 5;2022:6010504. doi: 10.1155/2022/6010504. eCollection 
      2022.