PMID- 35581439
OWN - NLM
STAT- MEDLINE
DCOM- 20220811
LR  - 20220811
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 279
IP  - 9
DP  - 2022 Sep
TI  - Association between pathological differentiation and survival outcomes of 
      patients with laryngeal squamous cell carcinoma.
PG  - 4595-4604
LID - 10.1007/s00405-022-07420-9 [doi]
AB  - PURPOSE: To investigate the prognostic value of histopathological differentiation 
      for the survival of patients with laryngeal squamous cell carcinoma (LSCC). 
      MATERIALS AND METHODS: Retrospective clinical and histopathological 
      differentiation data on consecutive cases of LSCC from a single institution over 
      a 10-years period were collected and analyzed in this study. Oncological outcomes 
      were assessed based on disease-specific survival (DSS), disease-free survival 
      (DFS), and overall survival (OS) using the Kaplan-Meier method and Cox 
      proportional hazards regression analysis. Propensity score matching (PSM) was 
      performed to reduce or eliminate the bias due to confounding variables. RESULTS: 
      A total of 998 LSCC cases were identified in this study. As compared to well to 
      moderately differentiated LSCC, poorly differentiated tumors had adjusted hazard 
      ratios (aHRs) of 1.78 (95% confidence interval [CI] 1.31-2.43), 2.00 (95% CI 
      1.51-2.65), and 1.72 (95% CI 1.28-2.31) for DSS, DFS, and OS, respectively. The 
      new patient cohort consisted of 138 patients with well to moderately 
      differentiated LSCC and 138 patients with poorly differentiated LSCC after PSM. 
      The survival outcomes of patients with well to moderately differentiated LSCCs 
      were significantly better than those of patients with poorly differentiated 
      tumors in DSS (aHR 1.91; 95% CI 1.24-2.95), DFS (aHR 2.07; 95% CI 1.37-3.12), and 
      OS (aHR 2.14; 95% CI 1.39-3.28). CONCLUSION: This study showed that survival 
      outcomes of patients with poorly differentiated LSCC were significantly worse 
      than those of patients with well to moderately differentiated LSCC. In addition, 
      histopathological differentiation is an important prognostic factor for LSCC 
      survival. Therefore, further treatment plans should focus on poorly 
      differentiated LSCC to improve the survival outcomes.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Zhu, Yingying
AU  - Zhu Y
AD  - Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College 
      and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, 
      No. 1, Shuaifuyuan, Wangfujing, Beijing, 100730, China.
FAU - Shi, Xiaohua
AU  - Shi X
AD  - Department of Pathology, Peking Union Medical College and Chinese Academy of 
      Medical Sciences, Peking Union Medical College Hospital, Beijing, 100730, China.
FAU - Zhu, Xiaoli
AU  - Zhu X
AD  - Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College 
      and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, 
      No. 1, Shuaifuyuan, Wangfujing, Beijing, 100730, China.
FAU - Diao, Wenwen
AU  - Diao W
AD  - Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College 
      and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, 
      No. 1, Shuaifuyuan, Wangfujing, Beijing, 100730, China.
FAU - Chen, Xingming
AU  - Chen X
AUID- ORCID: 0000-0002-4386-6280
AD  - Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College 
      and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, 
      No. 1, Shuaifuyuan, Wangfujing, Beijing, 100730, China. chenxm_ql2021@163.com.
LA  - eng
PT  - Journal Article
DEP - 20220518
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - *Carcinoma, Squamous Cell/pathology
MH  - *Head and Neck Neoplasms
MH  - Humans
MH  - *Laryngeal Neoplasms/surgery
MH  - Prognosis
MH  - Retrospective Studies
MH  - Squamous Cell Carcinoma of Head and Neck
OTO - NOTNLM
OT  - Differentiation
OT  - Laryngeal neoplasms
OT  - Prognosis
OT  - Squamous cell carcinoma
OT  - Survival
EDAT- 2022/05/18 06:00
MHDA- 2022/08/12 06:00
CRDT- 2022/05/17 23:31
PHST- 2022/02/02 00:00 [received]
PHST- 2022/04/21 00:00 [accepted]
PHST- 2022/05/18 06:00 [pubmed]
PHST- 2022/08/12 06:00 [medline]
PHST- 2022/05/17 23:31 [entrez]
AID - 10.1007/s00405-022-07420-9 [pii]
AID - 10.1007/s00405-022-07420-9 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2022 Sep;279(9):4595-4604. doi: 
      10.1007/s00405-022-07420-9. Epub 2022 May 18.