PMID- 35583670
OWN - NLM
STAT- MEDLINE
DCOM- 20220719
LR  - 20220719
IS  - 1432-1106 (Electronic)
IS  - 0014-4819 (Linking)
VI  - 240
IP  - 7-8
DP  - 2022 Aug
TI  - BOLD turnover in task-free state: variation among brain areas and effects of age 
      and human leukocyte antigen (HLA) DRB1*13.
PG  - 1967-1977
LID - 10.1007/s00221-022-06382-y [doi]
AB  - Blood oxygen level dependent (BOLD) signal in functional magnetic resonance 
      imaging (fMRI) is frequently used as a proxy for underlying neural activity. 
      Although this is a plausible assumption for experiments where a task is 
      performed, it may not hold to the same degree for conditions of fMRI recording in 
      a task-free, "resting" state where neural synaptic events are weak and, hence, 
      neurovascular coupling and endothelial vascular factors become more prominent 
      (Hillman Annu Rev Neurosci 37:161-181, 2014, 
      10.1146/annurev-neuro-071013-014111). Here we investigated the magnitude of 
      change of BOLD in consecutive samples over the acquisition time period (turnover 
      of BOLD, "TBOLD") by first-order differencing of single-voxel BOLD time series 
      acquired in 70 areas of the cerebral cortex of 57 cognitively healthy women in a 
      task-free resting state. More specifically, we evaluated (a) the variation of 
      TBOLD among different cortical areas, (b) its dependence on age, and (c) its 
      dependence on the presence (or absence) of the neuroprotective Human Leukocyte 
      Antigen (HLA) gene DRB1*13 (DRB1*13:02 and DRB1*13:01). We found that TBOLD (a) 
      varied substantially by 2.2 x among cortical areas, being highest in 
      parahippocampal and entorhinal areas and lowest in parietal-occipital areas, (b) 
      was significantly reduced in DRB1*13 carriers across cortical areas (from ~ 15% 
      reduction in orbitofrontal cortex to 2% reduction in cuneus), and (c) increased 
      with age in noncarriers of DRB1*13 but decreased with age in DRB1*13 carriers. 
      These findings document significant dependencies of TBOLD on cortical area 
      location, HLA DRB1*13 and age.
CI  - (c) 2022. This is a U.S. government work and not under copyright protection in the 
      U.S.; foreign copyright protection may apply.
FAU - James, Lisa M
AU  - James LM
AD  - Department of Veterans Affairs Health Care System, The Neuroimaging Research 
      Group, Brain Sciences Center, Minneapolis, MN, 55417, USA.
AD  - Department of Neuroscience, University of Minnesota Medical School, Minneapolis, 
      MN, 55455, USA.
AD  - Department of Psychiatry, University of Minnesota Medical School, Minneapolis, 
      MN, 55455, USA.
FAU - Christova, Peka
AU  - Christova P
AD  - Department of Veterans Affairs Health Care System, The Neuroimaging Research 
      Group, Brain Sciences Center, Minneapolis, MN, 55417, USA.
AD  - Department of Neuroscience, University of Minnesota Medical School, Minneapolis, 
      MN, 55455, USA.
FAU - Georgopoulos, Apostolos P
AU  - Georgopoulos AP
AUID- ORCID: 0000-0003-4412-725X
AD  - Department of Veterans Affairs Health Care System, The Neuroimaging Research 
      Group, Brain Sciences Center, Minneapolis, MN, 55417, USA. omega@umn.edu.
AD  - Department of Neuroscience, University of Minnesota Medical School, Minneapolis, 
      MN, 55455, USA. omega@umn.edu.
AD  - Department of Psychiatry, University of Minnesota Medical School, Minneapolis, 
      MN, 55455, USA. omega@umn.edu.
AD  - Department of Neurology, University of Minnesota Medical School, Minneapolis, MN, 
      55455, USA. omega@umn.edu.
AD  - Brain Sciences Center (11B), Minneapolis VAHCS, One Veterans Drive, Minneapolis, 
      MN, 55417, USA. omega@umn.edu.
LA  - eng
PT  - Journal Article
DEP - 20220518
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
RN  - 0 (HLA-DRB1 Chains)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Brain/diagnostic imaging
MH  - *Brain Mapping
MH  - Cerebrovascular Circulation
MH  - Female
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - *Neurovascular Coupling
MH  - Oxygen
OTO - NOTNLM
OT  - Acetylcholine
OT  - Age
OT  - BOLD turnover
OT  - DRB1*13
OT  - Human leukocyte antigen
OT  - Neuroinflammation
OT  - Resting-state fMRI
EDAT- 2022/05/19 06:00
MHDA- 2022/07/20 06:00
CRDT- 2022/05/18 11:39
PHST- 2022/03/07 00:00 [received]
PHST- 2022/04/25 00:00 [accepted]
PHST- 2022/05/19 06:00 [pubmed]
PHST- 2022/07/20 06:00 [medline]
PHST- 2022/05/18 11:39 [entrez]
AID - 10.1007/s00221-022-06382-y [pii]
AID - 10.1007/s00221-022-06382-y [doi]
PST - ppublish
SO  - Exp Brain Res. 2022 Aug;240(7-8):1967-1977. doi: 10.1007/s00221-022-06382-y. Epub 
      2022 May 18.