PMID- 35584835
OWN - NLM
STAT- MEDLINE
DCOM- 20220520
LR  - 20240426
IS  - 1473-4893 (Electronic)
IS  - 1470-2118 (Print)
IS  - 1470-2118 (Linking)
VI  - 22
IP  - 3
DP  - 2022 May
TI  - Lessons of the month 2: Olanzapine-induced hypothermia and hand oedema.
PG  - 285-286
LID - 10.7861/clinmed.2022-0113 [doi]
AB  - INTRODUCTION: We describe a case of olanzapine-induced hypothermia and hand 
      oedema in an older adult with behavioural and psychological symptoms of dementia 
      (BPSD). CASE PRESENTATION: An 82-year-old woman with hypothyroidism and dementia 
      was reviewed by the geriatric team at a nursing home in view of lethargy and an 
      unrecordable oral temperature. She was noted to have a bilateral hand oedema and 
      right basal crackles. Investigations revealed high white cell count and 
      inflammatory markers. She was treated as per hypothermia and communityacquired 
      pneumonia protocols. The patient did not have the expected response to treatment. 
      Olanzapine was tailed down and stopped with good effect as it was suspected to be 
      a contributory cause to both the hypothermia and oedema. DISCUSSION AND 
      CONCLUSION: Potentially inappropriate polypharmacy can be specifically targeted 
      with effective deprescribing. Treatment review should be encouraged on a regular 
      basis, especially in frail older adults with polypharmacy.
CI  - (c) Royal College of Physicians 2022. All rights reserved.
FAU - Camilleri, Doriella
AU  - Camilleri D
AD  - St Vincent De Paul Long-Term Care Facility, Luqa, Malta galeadoriella@gmail.com.
FAU - Fiorini, Anthony
AU  - Fiorini A
AD  - St Vincent De Paul Long-Term Care Facility, Luqa, Malta.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Clin Med (Lond)
JT  - Clinical medicine (London, England)
JID - 101092853
RN  - N7U69T4SZR (Olanzapine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Dementia/drug therapy
MH  - *Deprescriptions
MH  - Edema
MH  - Female
MH  - Humans
MH  - *Hypothermia/chemically induced
MH  - *Hypothermia, Induced
MH  - Olanzapine
MH  - Polypharmacy
PMC - PMC9135083
OTO - NOTNLM
OT  - deprescribing
OT  - hypothermia
OT  - oedema
OT  - olanzapine
OT  - polypharmacy
EDAT- 2022/05/19 06:00
MHDA- 2022/05/21 06:00
PMCR- 2022/05/01
CRDT- 2022/05/18 20:33
PHST- 2022/05/18 20:33 [entrez]
PHST- 2022/05/19 06:00 [pubmed]
PHST- 2022/05/21 06:00 [medline]
PHST- 2022/05/01 00:00 [pmc-release]
AID - S1470-2118(24)02971-3 [pii]
AID - clinmedicine [pii]
AID - 10.7861/clinmed.2022-0113 [doi]
PST - ppublish
SO  - Clin Med (Lond). 2022 May;22(3):285-286. doi: 10.7861/clinmed.2022-0113.