PMID- 35585788
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20231127
IS  - 1708-539X (Electronic)
IS  - 1708-5381 (Linking)
VI  - 31
IP  - 6
DP  - 2023 Dec
TI  - Evaluation of three nutritional indices as predictors of 2-year mortality and 
      major amputation in patients with chronic limb-threatening ischemia.
PG  - 1094-1102
LID - 10.1177/17085381221102801 [doi]
AB  - OBJECTIVE: The present study aimed to examine which nutritional index, such as 
      the controlling nutritional status (CONUT), prognostic nutritional index (PNI), 
      and geriatric nutritional risk index (GNRI), is better for predicting prognosis 
      in patients with chronic limb-threatening ischemia (CLTI) following 
      revascularization. METHOD: We retrospectively analyzed data of patients who 
      underwent revascularization for CLTI between 2008 and 2020. The endpoints were 
      2-year overall survival and limb salvage. The optimal cutoff values of 2-year 
      overall survival and major amputation were determined by receiver operating 
      characteristic curve analyses. RESULT: A total of 238 patients with CLTI and 289 
      limbs were analyzed. The 2-year overall survival rates were 48.9%, 54.6%, and 
      53.5% in patients with CONUT score >/=4, PNI score <42.6, and GNRI <98.4 compared 
      with 80.0%, 80.0%, and 78.4% in patients with CONUT score <4, PNI score >/=42.6, 
      and GNRI >/=98.4 (p < 0.01). Age, non-ambulatory status, hemodialysis, and 
      nutritional indices were independent risk factors for 2-year mortality in the 
      multivariate analyses. The 2-year limb salvage rates were 70.1%, 82.2%, and 81.9% 
      in patients with CONUT score >/=7, PNI score <41.9, and GNRI <95.3 compared with 
      92.8%, 98.3%, and 94.2% in patients with CONUT score <7, PNI score >/=41.9, and 
      GNRI >/=95.3 (p < 0.01). Wound, ischemia, and foot infection stage and each 
      nutritional index (CONUT and PNI) were independent risk factors for major 
      amputation in multivariate analyses. The overall survival and limb salvage rates 
      of patients with malnutrition diagnosed by CONUT score were poor compared with 
      those of normal nutrition or malnutrition diagnosed by PNI and/or GNRI scores. 
      CONCLUSION: The CONUT, PNI, and GNRI scores can predict the 2-year overall 
      survival in patients with CLTI after revascularization. The CONUT and PNI scores 
      were associated with major amputation.
FAU - Morisaki, Koichi
AU  - Morisaki K
AUID- ORCID: 0000-0003-4872-4115
AD  - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu 
      University, Fukuoka, Japan. RINGGOLD: 12923
FAU - Matsubara, Yutaka
AU  - Matsubara Y
AUID- ORCID: 0000-0002-9187-8403
AD  - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu 
      University, Fukuoka, Japan. RINGGOLD: 12923
FAU - Kurose, Shun
AU  - Kurose S
AD  - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu 
      University, Fukuoka, Japan. RINGGOLD: 12923
FAU - Yoshino, Shinichiro
AU  - Yoshino S
AD  - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu 
      University, Fukuoka, Japan. RINGGOLD: 12923
FAU - Furuyama, Tadashi
AU  - Furuyama T
AUID- ORCID: 0000-0003-0042-2986
AD  - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu 
      University, Fukuoka, Japan. RINGGOLD: 12923
LA  - eng
PT  - Journal Article
DEP - 20220518
PL  - England
TA  - Vascular
JT  - Vascular
JID - 101196722
SB  - IM
MH  - Humans
MH  - Aged
MH  - *Nutrition Assessment
MH  - Chronic Limb-Threatening Ischemia
MH  - Retrospective Studies
MH  - Nutritional Status
MH  - *Malnutrition/diagnosis
MH  - Prognosis
MH  - Risk Factors
MH  - Amputation, Surgical
OTO - NOTNLM
OT  - Chronic limb-threatening ischemia
OT  - controlling nutritional status
OT  - geriatric nutritional risk index
OT  - major amputation
OT  - overall survival
OT  - prognostic nutritional index
COIS- Declaration of conflicting interestsThe author(s) declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2022/05/20 06:00
MHDA- 2023/11/27 12:43
CRDT- 2022/05/19 01:42
PHST- 2023/11/27 12:43 [medline]
PHST- 2022/05/20 06:00 [pubmed]
PHST- 2022/05/19 01:42 [entrez]
AID - 10.1177/17085381221102801 [doi]
PST - ppublish
SO  - Vascular. 2023 Dec;31(6):1094-1102. doi: 10.1177/17085381221102801. Epub 2022 May 
      18.