PMID- 35586830
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 10
DP  - 2022
TI  - An Evaluation of Serum IgE and Th2-Associated Interleukins in Children With 
      Uncomplicated and Complicated Appendicitis.
PG  - 884138
LID - 10.3389/fped.2022.884138 [doi]
LID - 884138
AB  - BACKGROUND: The pathogenesis of appendicitis is not understood completely and 
      establishing a correct diagnosis can be clinically challenging. Previous 
      investigations have shown an association between a T helper cell (Th)2-mediated 
      inflammatory response, for example immunoglobulin E (IgE)-mediated allergy, and a 
      decreased risk of complicated appendicitis. The present study aimed to evaluate 
      differences in serum concentrations of IgE and Th2-associated interleukins (IL) 
      in children with uncomplicated and complicated appendicitis. METHOD: A 
      prospective study including children <15 years with appendicitis. Blood samples 
      were collected preoperatively at the time of clinical assessment at the Pediatric 
      Emergency Department and analyzed for concentrations of serum total IgE and IL-4, 
      IL-9, and IL-13. Associations with complicated appendicitis were evaluated 
      through logistic regression adjusting for age, appendicolith, and symptom 
      duration. RESULTS: 138 children with confirmed appendicitis were included. The 
      median age was 10 (IQR 8-12) years, 87 (63%) were boys and 58 (42%) had 
      complicated appendicitis. Children with complicated appendicitis had 
      significantly higher concentrations of IL-9 and IL-13 compared to children with 
      uncomplicated appendicitis. In the univariate logistic regression, high 
      concentrations of IL-13 were associated with an increased risk of complicated 
      appendicitis [OR 1.02 (95% CI 1.01-1.04) p = 0.005], which remained in the 
      multivariate analysis [aOR 1.02 (95% CI 1.01-1.04), p = 0.01]. Serum 
      concentrations of IgE, IL-4, and IL-9 did not significantly affect the risk of 
      complicated appendicitis. CONCLUSION: High levels of IL-13 seem to be associated 
      with an increased risk of complicated appendicitis. This is incongruent with the 
      hypothesis of an Th1/Th17-driven inflammation in this type of appendicitis.
CI  - Copyright (c) 2022 Gudjonsdottir, Roth, Loven, Ohlsson, Hagander and Salo.
FAU - Gudjonsdottir, Johanna
AU  - Gudjonsdottir J
AD  - Department of Clinical Sciences, Pediatrics, Lund University, Lund, Sweden.
AD  - Department of Surgery, Skane University Hospital, Malmo, Sweden.
FAU - Roth, Bodil
AU  - Roth B
AD  - Department of Internal Medicine, Skane University Hospital, Malmo, Sweden.
AD  - Department of Clinical Sciences, Lund University, Malmo, Sweden.
FAU - Loven, Gustav
AU  - Loven G
AD  - Department of Clinical Sciences, Pediatrics, Lund University, Lund, Sweden.
FAU - Ohlsson, Bodil
AU  - Ohlsson B
AD  - Department of Internal Medicine, Skane University Hospital, Malmo, Sweden.
AD  - Department of Clinical Sciences, Lund University, Malmo, Sweden.
FAU - Hagander, Lars
AU  - Hagander L
AD  - Department of Clinical Sciences, Pediatrics, Lund University, Lund, Sweden.
AD  - Department of Pediatric Surgery, Skane University Hospital, Lund, Sweden.
FAU - Salo, Martin
AU  - Salo M
AD  - Department of Clinical Sciences, Pediatrics, Lund University, Lund, Sweden.
AD  - Department of Pediatric Surgery, Skane University Hospital, Lund, Sweden.
LA  - eng
PT  - Journal Article
DEP - 20220502
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC9108389
OTO - NOTNLM
OT  - IgE
OT  - Th2
OT  - appendicitis
OT  - children
OT  - interleukins
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/05/20 06:00
MHDA- 2022/05/20 06:01
PMCR- 2022/05/02
CRDT- 2022/05/19 02:32
PHST- 2022/02/25 00:00 [received]
PHST- 2022/04/01 00:00 [accepted]
PHST- 2022/05/19 02:32 [entrez]
PHST- 2022/05/20 06:00 [pubmed]
PHST- 2022/05/20 06:01 [medline]
PHST- 2022/05/02 00:00 [pmc-release]
AID - 10.3389/fped.2022.884138 [doi]
PST - epublish
SO  - Front Pediatr. 2022 May 2;10:884138. doi: 10.3389/fped.2022.884138. eCollection 
      2022.