PMID- 35587164
OWN - NLM
STAT- MEDLINE
DCOM- 20230308
LR  - 20230308
IS  - 2295-3337 (Electronic)
IS  - 1784-3286 (Linking)
VI  - 78
IP  - 2
DP  - 2023 Apr
TI  - Hepatic arterial infusion chemotherapy versus transarterial chemoembolization for 
      patients with unresectable hepatocellular carcinoma: a systematic review and 
      meta-analysis.
PG  - 171-179
LID - 10.1080/17843286.2022.2076791 [doi]
AB  - BACKGROUND: We carried out a systematic review and meta-analysis to assess the 
      safety and effectiveness of hepatic arterial infusion chemotherapy (HAIC) 
      compared with transarterial chemoembolization (TACE) for patients with 
      unresectable hepatocellular carcinoma (uHCC). METHODS: Eligible studies were 
      searched by MEDLINE, the Cochrane Library, Embase, and Web of Science from 
      January 1995 to January 2022, investigating eligible literature comparing HAIC 
      and TACE for patients with HCC. The main outcome measures included 
      progression-free survival (PFS), overall survival (OS), adverse events (AEs), 
      objective response rate (ORR), and diseases control rate (DCR). RESULTS: Eight 
      literature and 1028 patients were enrolled in this meta-analysis. The pooled PFS, 
      OS, ORR, and DCR were HR = 0.89 (95% CI, 0.81-0.98), HR = 0.84 (95% CI, 
      0.75-0.93), OR = 2.77 (95% CI, 2.01-3.80), and OR = 4.64 (95% CI, 2.40-8.99), 
      respectively. The adverse events of HAIC were lower than TACE. CONCLUSION: Our 
      meta-analysis revealed that HAIC can achieve a better effect and survival 
      benefits than TACE in patients with uHCC.
FAU - Kong, Shun-Yu
AU  - Kong SY
AD  - Department of Interventional Therapy, Affiliated Hospital of Qinghai University, 
      Xining, China.
AD  - Department of Postgraduate, Qinghai University, Xining, China.
FAU - Song, Jiao-Jiao
AU  - Song JJ
AD  - Department of Postgraduate, Qinghai University, Xining, China.
AD  - Department of Ultrasound, Qinghai Province Hospital, Xining, China.
FAU - Jin, Yao-Qi
AU  - Jin YQ
AD  - XiangYa School of Medicine, Central South University, Changsha, China.
FAU - Deng, Man-Jun
AU  - Deng MJ
AD  - Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai 
      University, Xining, China.
FAU - Yan, Jing-Xin
AU  - Yan JX
AUID- ORCID: 0000-0002-2734-6146
AD  - Department of Interventional Therapy, Affiliated Hospital of Qinghai University, 
      Xining, China.
AD  - Department of Postgraduate, Qinghai University, Xining, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20220519
PL  - England
TA  - Acta Clin Belg
JT  - Acta clinica Belgica
JID - 0370306
SB  - IM
MH  - Humans
MH  - *Carcinoma, Hepatocellular/drug therapy/pathology
MH  - *Liver Neoplasms/drug therapy/pathology
MH  - *Chemoembolization, Therapeutic/adverse effects
MH  - Infusions, Intra-Arterial
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Hepatic arterial infusion chemotherapy
OT  - hepatocellular carcinoma
OT  - meta-analysis
OT  - systematic review
OT  - transarterial chemoembolization
EDAT- 2022/05/20 06:00
MHDA- 2023/03/09 06:00
CRDT- 2022/05/19 08:13
PHST- 2022/05/20 06:00 [pubmed]
PHST- 2023/03/09 06:00 [medline]
PHST- 2022/05/19 08:13 [entrez]
AID - 10.1080/17843286.2022.2076791 [doi]
PST - ppublish
SO  - Acta Clin Belg. 2023 Apr;78(2):171-179. doi: 10.1080/17843286.2022.2076791. Epub 
      2022 May 19.