PMID- 35587669
OWN - NLM
STAT- MEDLINE
DCOM- 20220523
LR  - 20220531
IS  - 1006-7248 (Print)
IS  - 1006-7248 (Linking)
VI  - 31
IP  - 1
DP  - 2022 Feb
TI  - [Analysis of material preparation, anti-bacterial activity of Porphyromonas 
      gingivalis and cell bioassays of TiO(2)-PEEK-CRGDS].
PG  - 54-57
AB  - PURPOSE: To modify polyetheretherketone(PEEK) composite material with nanometer 
      titanium dioxide (TiO(2)) and CRGDS peptide to prepare TiO(2)-PEEK-CRGDS, and 
      evaluate its anti- activity of Porphyromonas gingivalis and effect on cell 
      activity. METHODS: TiO(2)-PEEK was prepared by plasma immersion ion 
      implantation(PⅢ), then immersed into gelatin solution of pentapeptides of CRGDS, 
      and freeze-dried. The same diameter and thickness of PEEK was set as control. 
      Scanning electron microscope (SEM) was used to observe the three-dimensional 
      topography and roughness on the surface of the specimen, colony count was 
      calculated to evaluate the survival of Porphyromonas gingivalis, living/dead cell 
      count was used to detect the activity of human gingival fibroblasts(HGFs), CCK-8 
      assay was used to detect the proliferation ability of HGFs. The quantitative data 
      was indicated as and analyzed by using GraphPad Prism 7.0 software package. 
      RESULTS: The antibacterial rates of PEEK, TiO(2)-PEEK and TiO(2)-PEEK-CRGDS were 
      40.3%, 57.2% and 60.3%, respectively. At 12 days, the ability of 
      TiO(2)-PEEK-CRGDS to promote the growth of human gingival fibroblasts was 
      significantly different from that of the TiO(2)-PEEK and PEEK group(P＜0.05). 
      CONCLUSIONS: The optimized TiO(2)-PEEK-CRGDS has better hydrophilicity than pure 
      titanium and PEEK, and can significantly promote the proliferation of gingival 
      fibroblasts.
FAU - Xu, Xin-Yi
AU  - Xu XY
AD  - Department of Stomatology, Changzhou Hospital of Traditional Chinese Medicine. 
      Changzhou 213003, China. E-mail: xxy7956@sina.com.
FAU - Zhang, Ying-Lian
AU  - Zhang YL
LA  - chi
PT  - Journal Article
PL  - China
TA  - Shanghai Kou Qiang Yi Xue
JT  - Shanghai kou qiang yi xue = Shanghai journal of stomatology
JID - 101090220
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Benzophenones)
RN  - 0 (Ketones)
RN  - 0 (Polymers)
RN  - 15FIX9V2JP (titanium dioxide)
RN  - 31694-16-3 (polyetheretherketone)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Benzophenones
MH  - Biological Assay
MH  - Humans
MH  - *Ketones/pharmacology
MH  - Polyethylene Glycols/pharmacology
MH  - Polymers
MH  - *Porphyromonas gingivalis
MH  - Surface Properties
MH  - Titanium
EDAT- 2022/05/20 06:00
MHDA- 2022/05/24 06:00
CRDT- 2022/05/19 15:38
PHST- 2022/05/19 15:38 [entrez]
PHST- 2022/05/20 06:00 [pubmed]
PHST- 2022/05/24 06:00 [medline]
PST - ppublish
SO  - Shanghai Kou Qiang Yi Xue. 2022 Feb;31(1):54-57.