PMID- 35588783
OWN - NLM
STAT- MEDLINE
DCOM- 20220621
LR  - 20231213
IS  - 1096-0007 (Electronic)
IS  - 0014-4835 (Print)
IS  - 0014-4835 (Linking)
VI  - 220
DP  - 2022 Jul
TI  - Quantitative and qualitative characterization of retinal dystrophies in canine 
      models of inherited retinal diseases using spectral domain optical coherence 
      tomography (SD-OCT).
PG  - 109106
LID - S0014-4835(22)00186-5 [pii]
LID - 10.1016/j.exer.2022.109106 [doi]
AB  - The purpose of this study was to establish spectral domain optical coherence 
      tomography (SD-OCT) assessment data in well-established canine models of 
      inherited retinal dystrophies: PDE6B-rod-cone dysplasia 1 (RCD1: early onset 
      retinitis pigmentosa), PRCD-progressive rod-cone degeneration (PRCD: late onset 
      retinitis pigmentosa), CNGB3-achromatopsia, and RPE65-Leber congenital amaurosis 
      (LCA). High resolution SD-OCT images of the retina were acquired from both eyes 
      in 5 planes: temporal; superotemporal; superior; nasal; and inferior in adult 
      dogs with: RCD1 (n = 4 dogs, median age: 1.5 yrs); PRCD (n = 2, 4.3 yrs); LCA 
      (n = 3, 5.2 yrs); achromatopsia (n = 3, 4.2 yrs); and wild types (wt, n = 6, 
      5.5 yrs). Total, inner and outer retinal thicknesses and ellipsoid zone were 
      analyzed. In selected animals, histomorphometric evaluations were performed. In 
      dogs with RCD1, PRCD, and LCA, the thickness of the outer retina was, compared to 
      wt, significantly decreased (p </= 0.02) in all OCT imaging planes, and in 
      superotemporal and inferior imaging planes in dogs with achromatopsia. No 
      significant thinning was observed in inner retina thickness in any disease model 
      except in the inferior imaging plane in dogs with RCD1. Dogs with RCD1, PRCD, and 
      LCA had significantly more areas with disrupted ellipsoid zone in the presumed 
      area centralis than wt (p </= 0.001). OCT findings provide baseline information for 
      research of retinal dystrophies using these canine models.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Park, Shin Ae
AU  - Park SA
AD  - Department of Small Animal Clinical Sciences, College of Veterinary Medicine, 
      Michigan State University, East Lansing, MI, USA; Department of Clinical 
      Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, 
      USA. Electronic address: park1222@purdue.edu.
FAU - Rhodes, Jamie
AU  - Rhodes J
AD  - Department of Clinical Sciences & Advanced Medicine, School of Veterinary 
      Medicine, University of Pennsylvania, Philadelphia, PA, USA.
FAU - Iwabe, Simone
AU  - Iwabe S
AD  - Department of Clinical Sciences & Advanced Medicine, School of Veterinary 
      Medicine, University of Pennsylvania, Philadelphia, PA, USA.
FAU - Ying, Gui-Shuang
AU  - Ying GS
AD  - Department of Ophthalmology, School of Medicine, University of Pennsylvania, 
      Philadelphia, PA, USA.
FAU - Pan, Wei
AU  - Pan W
AD  - Department of Ophthalmology, School of Medicine, University of Pennsylvania, 
      Philadelphia, PA, USA.
FAU - Huang, Jiayan
AU  - Huang J
AD  - Department of Ophthalmology, School of Medicine, University of Pennsylvania, 
      Philadelphia, PA, USA.
FAU - Komaromy, Andras M
AU  - Komaromy AM
AD  - Department of Small Animal Clinical Sciences, College of Veterinary Medicine, 
      Michigan State University, East Lansing, MI, USA; Department of Clinical Sciences 
      & Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, 
      Philadelphia, PA, USA. Electronic address: komaromy@msu.edu.
LA  - eng
GR  - K08 EY030950/EY/NEI NIH HHS/United States
GR  - R01 EY006855/EY/NEI NIH HHS/United States
GR  - R01 EY019304/EY/NEI NIH HHS/United States
GR  - P30 EY001583/EY/NEI NIH HHS/United States
GR  - K12 EY015398/EY/NEI NIH HHS/United States
GR  - R01 EY025752/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20220516
PL  - England
TA  - Exp Eye Res
JT  - Experimental eye research
JID - 0370707
RN  - Achromatopsia 3
SB  - IM
MH  - Animals
MH  - *Color Vision Defects/diagnostic imaging/genetics
MH  - Dogs
MH  - Retina/diagnostic imaging
MH  - *Retinal Dystrophies/diagnostic imaging/genetics
MH  - *Retinitis Pigmentosa/diagnostic imaging/genetics
MH  - Tomography, Optical Coherence
PMC - PMC9789526
MID - NIHMS1854348
OTO - NOTNLM
OT  - Achromatopsia
OT  - CNGB3
OT  - Dog
OT  - LCA
OT  - PDE6B
OT  - PRCD
OT  - RCD1
OT  - RPE65
EDAT- 2022/05/20 06:00
MHDA- 2022/06/22 06:00
PMCR- 2023/07/01
CRDT- 2022/05/19 20:02
PHST- 2022/02/04 00:00 [received]
PHST- 2022/04/19 00:00 [revised]
PHST- 2022/05/06 00:00 [accepted]
PHST- 2022/05/20 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2022/05/19 20:02 [entrez]
PHST- 2023/07/01 00:00 [pmc-release]
AID - S0014-4835(22)00186-5 [pii]
AID - 10.1016/j.exer.2022.109106 [doi]
PST - ppublish
SO  - Exp Eye Res. 2022 Jul;220:109106. doi: 10.1016/j.exer.2022.109106. Epub 2022 May 
      16.