PMID- 35589962
OWN - NLM
STAT- MEDLINE
DCOM- 20220727
LR  - 20221120
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Print)
IS  - 0307-0565 (Linking)
VI  - 46
IP  - 8
DP  - 2022 Aug
TI  - In-utero co-exposure to toxic metals and micronutrients on childhood risk of 
      overweight or obesity: new insight on micronutrients counteracting toxic metals.
PG  - 1435-1445
LID - 10.1038/s41366-022-01127-x [doi]
AB  - BACKGROUND/OBJECTIVES: Low-level, in-utero exposure to toxic metals such as lead 
      (Pb) and mercury (Hg) is widespread in the US and worldwide; and, individually, 
      was found to be obesogenic in children. To address the literature gaps on the 
      health effects of co-exposure to low-level toxic metals and the lack of 
      intervention strategy, we aimed to investigate the association between in-utero 
      co-exposure to Hg, Pb, cadmium (Cd) and childhood overweight or obesity (OWO) and 
      whether adequate maternal micronutrients (selenium (Se) and folate) can be 
      protective. SUBJECTS/METHODS: This study included 1442 mother-child pairs from 
      the Boston Birth Cohort, a predominantly urban, low-income, Black, and Hispanic 
      population, who were enrolled at birth and followed prospectively up to age 15 
      years. Bayesian kernel machine regression (BKMR) was applied to estimate 
      individual and joint effects of exposures to metals and micronutrients on 
      childhood OWO while adjusting for pertinent covariables. Stratified analyses by 
      maternal OWO and micronutrient status were performed to identify sensitive 
      subgroups. RESULTS: In this sample of understudied US children, low-level 
      in-utero co-exposure to Hg, Pb, and Cd was widespread. Besides individual 
      positive associations of maternal Hg and Pb exposure with offspring OWO, BKMR 
      clearly indicated a positive dose-response association between in-utero 
      co-exposure to the three toxic metals and childhood OWO. Notably, the metal 
      mixture-OWO association was more pronounced in children born to mothers with OWO; 
      and in such a setting, the association was greatly attenuated if mothers had 
      higher Se and folate levels. CONCLUSIONS: In this prospective cohort of US 
      children at high-risk of toxic metal exposure and OWO, we demonstrated that among 
      children born to mothers with OWO, low-level in-utero co-exposure to Hg, Pb, and 
      Cd increased the risk of childhood OWO; and that adequate maternal Se and folate 
      levels mitigated the risk of childhood OWO. CLINICAL TRIAL REGISTRY NUMBER AND 
      WEBSITE WHERE IT WAS OBTAINED: NCT03228875.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Nature Limited.
FAU - Huang, Wanyu
AU  - Huang W
AUID- ORCID: 0000-0002-7276-5892
AD  - Department of Civil and Systems Engineering, Johns Hopkins University Whiting 
      School of Engineering, Baltimore, MD, USA.
FAU - Igusa, Tak
AU  - Igusa T
AD  - Department of Civil and Systems Engineering, Johns Hopkins University Whiting 
      School of Engineering, Baltimore, MD, USA. tigusa1@jhu.edu.
AD  - Department of Applied Mathematics and Statistics, Johns Hopkins University 
      Whiting School of Engineering, Baltimore, MD, USA. tigusa1@jhu.edu.
FAU - Wang, Guoying
AU  - Wang G
AD  - Center on Early Life Origins of Disease, Department of Population, Family and 
      Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, 
      Baltimore, MD, USA.
FAU - Buckley, Jessie P
AU  - Buckley JP
AD  - Department of Environmental Health and Engineering, Johns Hopkins University 
      Bloomberg School of Public Health, Baltimore, MD, USA.
FAU - Hong, Xiumei
AU  - Hong X
AD  - Center on Early Life Origins of Disease, Department of Population, Family and 
      Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, 
      Baltimore, MD, USA.
FAU - Bind, Eric
AU  - Bind E
AUID- ORCID: 0000-0003-3074-2833
AD  - New Jersey Department of Health, Environmental and Chemical Laboratory Services, 
      Metals Laboratory, P. O. Box 360, Trenton, NJ, USA.
FAU - Steffens, Andrew
AU  - Steffens A
AD  - New Jersey Department of Health, Environmental and Chemical Laboratory Services, 
      Metals Laboratory, P. O. Box 360, Trenton, NJ, USA.
FAU - Mukherjee, Jhindan
AU  - Mukherjee J
AD  - New Jersey Department of Health, Environmental and Chemical Laboratory Services, 
      Metals Laboratory, P. O. Box 360, Trenton, NJ, USA.
FAU - Haltmeier, Douglas
AU  - Haltmeier D
AD  - New Jersey Department of Health, Environmental and Chemical Laboratory Services, 
      Metals Laboratory, P. O. Box 360, Trenton, NJ, USA.
FAU - Ji, Yuelong
AU  - Ji Y
AD  - Center on Early Life Origins of Disease, Department of Population, Family and 
      Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, 
      Baltimore, MD, USA.
FAU - Xu, Richard
AU  - Xu R
AD  - Department of Biostatistics, Johns Hopkins University Bloomberg School of Public 
      Health, Baltimore, MD, USA.
FAU - Hou, Wenpin
AU  - Hou W
AD  - Department of Biostatistics, Johns Hopkins University Bloomberg School of Public 
      Health, Baltimore, MD, USA.
FAU - Tina Fan, Zhihua
AU  - Tina Fan Z
AD  - New Jersey Department of Health, Environmental and Chemical Laboratory Services, 
      Metals Laboratory, P. O. Box 360, Trenton, NJ, USA.
FAU - Wang, Xiaobin
AU  - Wang X
AUID- ORCID: 0000-0003-4451-302X
AD  - Center on Early Life Origins of Disease, Department of Population, Family and 
      Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, 
      Baltimore, MD, USA. xwang82@jhu.edu.
AD  - Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, 
      MD, USA. xwang82@jhu.edu.
LA  - eng
SI  - ClinicalTrials.gov/NCT03228875
GR  - R01 ES031521/ES/NIEHS NIH HHS/United States
GR  - R21 HD066471/HD/NICHD NIH HHS/United States
GR  - R01 HD098232/HD/NICHD NIH HHS/United States
GR  - R01 ES031272/ES/NIEHS NIH HHS/United States
GR  - R21 ES011666/ES/NIEHS NIH HHS/United States
GR  - R01 HD086013/HD/NICHD NIH HHS/United States
GR  - R01 HD041702/HD/NICHD NIH HHS/United States
GR  - R03 ES029594/ES/NIEHS NIH HHS/United States
PT  - Clinical Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20220519
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
RN  - 0 (Metals)
RN  - 0 (Micronutrients)
RN  - 00BH33GNGH (Cadmium)
RN  - 2P299V784P (Lead)
RN  - 935E97BOY8 (Folic Acid)
RN  - FXS1BY2PGL (Mercury)
SB  - IM
MH  - Adolescent
MH  - Bayes Theorem
MH  - Cadmium/toxicity
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Folic Acid
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Lead/toxicity
MH  - Mercury/toxicity
MH  - *Metals/toxicity
MH  - *Micronutrients
MH  - Overweight/epidemiology
MH  - *Pediatric Obesity/epidemiology
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/epidemiology
MH  - Prospective Studies
PMC - PMC9329205
MID - NIHMS1798372
COIS- Competing Financial Interests The authors declare they have no actual or 
      potential competing financial interests.
EDAT- 2022/05/20 06:00
MHDA- 2022/07/28 06:00
PMCR- 2022/11/19
CRDT- 2022/05/19 23:32
PHST- 2022/02/17 00:00 [received]
PHST- 2022/04/13 00:00 [accepted]
PHST- 2022/04/11 00:00 [revised]
PHST- 2022/05/20 06:00 [pubmed]
PHST- 2022/07/28 06:00 [medline]
PHST- 2022/05/19 23:32 [entrez]
PHST- 2022/11/19 00:00 [pmc-release]
AID - 10.1038/s41366-022-01127-x [pii]
AID - 10.1038/s41366-022-01127-x [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2022 Aug;46(8):1435-1445. doi: 10.1038/s41366-022-01127-x. 
      Epub 2022 May 19.