PMID- 35590379
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2045-3701 (Print)
IS  - 2045-3701 (Electronic)
IS  - 2045-3701 (Linking)
VI  - 12
IP  - 1
DP  - 2022 May 19
TI  - Mitochondrial transfer/transplantation: an emerging therapeutic approach for 
      multiple diseases.
PG  - 66
LID - 10.1186/s13578-022-00805-7 [doi]
LID - 66
AB  - Mitochondria play a pivotal role in energy generation and cellular physiological 
      processes. These organelles are highly dynamic, constantly changing their 
      morphology, cellular location, and distribution in response to cellular stress. 
      In recent years, the phenomenon of mitochondrial transfer has attracted 
      significant attention and interest from biologists and medical investigators. 
      Intercellular mitochondrial transfer occurs in different ways, including 
      tunnelling nanotubes (TNTs), extracellular vesicles (EVs), and gap junction 
      channels (GJCs). According to research on intercellular mitochondrial transfer in 
      physiological and pathological environments, mitochondrial transfer hold great 
      potential for maintaining body homeostasis and regulating pathological processes. 
      Multiple research groups have developed artificial mitochondrial 
      transfer/transplantation (AMT/T) methods that transfer healthy mitochondria into 
      damaged cells and recover cellular function. This paper reviews intercellular 
      spontaneous mitochondrial transfer modes, mechanisms, and the latest methods of 
      AMT/T. Furthermore, potential application value and mechanism of AMT/T in disease 
      treatment are also discussed.
CI  - (c) 2022. The Author(s).
FAU - Liu, Zonghan
AU  - Liu Z
AD  - School of Physical Education & Health Care, East China Normal University, 
      Shanghai, China.
AD  - Key Laboratory of Adolescent Health Assessment and Exercise Intervention of 
      Ministry of Education, East China Normal University, Shanghai, China.
FAU - Sun, Yi
AU  - Sun Y
AD  - School of Physical Education & Health Care, East China Normal University, 
      Shanghai, China.
AD  - Key Laboratory of Adolescent Health Assessment and Exercise Intervention of 
      Ministry of Education, East China Normal University, Shanghai, China.
FAU - Qi, Zhengtang
AU  - Qi Z
AD  - School of Physical Education & Health Care, East China Normal University, 
      Shanghai, China.
AD  - Key Laboratory of Adolescent Health Assessment and Exercise Intervention of 
      Ministry of Education, East China Normal University, Shanghai, China.
FAU - Cao, Lu
AU  - Cao L
AD  - School of Physical Education & Health Care, East China Normal University, 
      Shanghai, China.
AD  - Key Laboratory of Adolescent Health Assessment and Exercise Intervention of 
      Ministry of Education, East China Normal University, Shanghai, China.
FAU - Ding, Shuzhe
AU  - Ding S
AUID- ORCID: 0000-0001-6466-7427
AD  - School of Physical Education & Health Care, East China Normal University, 
      Shanghai, China. szding@tyxx.ecnu.edu.cn.
AD  - Key Laboratory of Adolescent Health Assessment and Exercise Intervention of 
      Ministry of Education, East China Normal University, Shanghai, China. 
      szding@tyxx.ecnu.edu.cn.
LA  - eng
GR  - 11000-30190-513300/006/The Key Laboratory Construction Project of Adolescent 
      Health Assessment and Exercise Intervention of the Ministry of Education/
GR  - 31671241/National Natural Science Foundation of China/
GR  - 31600967/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Review
DEP - 20220519
PL  - England
TA  - Cell Biosci
JT  - Cell & bioscience
JID - 101561195
PMC - PMC9121600
OTO - NOTNLM
OT  - Ageing
OT  - Cancer therapy
OT  - Energy metabolism
OT  - Mitochondrial transfer
OT  - Mitochondrial transplantation
OT  - Stem cell
OT  - Tissue injury
OT  - mtDNA mutations and deletions
COIS- I declare that there is no competing interest.
EDAT- 2022/05/20 06:00
MHDA- 2022/05/20 06:01
PMCR- 2022/05/19
CRDT- 2022/05/19 23:51
PHST- 2021/12/18 00:00 [received]
PHST- 2022/05/01 00:00 [accepted]
PHST- 2022/05/19 23:51 [entrez]
PHST- 2022/05/20 06:00 [pubmed]
PHST- 2022/05/20 06:01 [medline]
PHST- 2022/05/19 00:00 [pmc-release]
AID - 10.1186/s13578-022-00805-7 [pii]
AID - 805 [pii]
AID - 10.1186/s13578-022-00805-7 [doi]
PST - epublish
SO  - Cell Biosci. 2022 May 19;12(1):66. doi: 10.1186/s13578-022-00805-7.