PMID- 35592137
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2056-3418 (Print)
IS  - 2056-3426 (Electronic)
IS  - 2056-3426 (Linking)
VI  - 9
DP  - 2022
TI  - Mg(OH)(2) nanosheets on Ti with immunomodulatory function for orthopedic 
      applications.
PG  - rbac027
LID - 10.1093/rb/rbac027 [doi]
LID - rbac027
AB  - Macrophages play a vital role for guiding the fate of osteogenesis- related 
      cells. It is well known that nano-topography and bioactive ions can directly 
      enhance osteogenic behavior. However, the effects of nano-structure combined with 
      bioactive ions release on macrophage polarization and the following osteogenesis 
      and angiogenesis are rarely reported. Herein, Mg(OH)(2) films with nano-sheet 
      structures were constructed on the surface of Ti using hydrothermal treatment. 
      The film presented nano-sheet topography and sustained release of Mg ions. The 
      results of in vitro culture of bone marrow-derived macrophages (BMDMs), including 
      PCR, western blot and flow cytometry suggested that the nano-Mg(OH)(2) films were 
      more favorable for macrophages polarizing to tissue healing M2 phenotype. 
      Moreover, air-pouch model confirmed that the nano-Mg(OH)(2) film coated Ti would 
      induce milder inflammation and thinner fibrous layer in vivo, compared with 
      untreated Ti. Furthermore, macrophages-conditioned culture mediums were collected 
      from nano-Mg(OH)(2) coated Ti group was superior for the osteogenic behaviors of 
      mice bone marrow stem cells and the angiogenic behaviors of human umbilical vein 
      endothelial cells. With harmonious early inflammatory response and subsequently 
      improved osteogenesis and angiogenesis, the nano-Mg(OH)(2) coated Ti is promising 
      for orthopedic applications.
CI  - (c) The Author(s) 2022. Published by Oxford University Press.
FAU - He, Yue
AU  - He Y
AD  - School of Medicine, South China University of Technology, Guangzhou 510006, 
      China.
AD  - Medical Research Center, Department of Orthopedics, Guangdong Provincial People's 
      Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
FAU - Yao, Mengyu
AU  - Yao M
AD  - Medical Research Center, Department of Orthopedics, Guangdong Provincial People's 
      Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
FAU - Zhou, Jielong
AU  - Zhou J
AD  - Medical Research Center, Department of Orthopedics, Guangdong Provincial People's 
      Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
FAU - Xie, Juning
AU  - Xie J
AD  - School of Medicine, South China University of Technology, Guangzhou 510006, 
      China.
AD  - Medical Research Center, Department of Orthopedics, Guangdong Provincial People's 
      Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
FAU - Liang, Changxiang
AU  - Liang C
AD  - Medical Research Center, Department of Orthopedics, Guangdong Provincial People's 
      Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
FAU - Yin, Dong
AU  - Yin D
AD  - Medical Research Center, Department of Orthopedics, Guangdong Provincial People's 
      Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
FAU - Huang, Shuaihao
AU  - Huang S
AD  - Medical Research Center, Department of Orthopedics, Guangdong Provincial People's 
      Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - School of Medicine, South China University of Technology, Guangzhou 510006, 
      China.
AD  - Medical Research Center, Department of Orthopedics, Guangdong Provincial People's 
      Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
FAU - Peng, Feng
AU  - Peng F
AUID- ORCID: 0000-0003-2366-2253
AD  - Medical Research Center, Department of Orthopedics, Guangdong Provincial People's 
      Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
FAU - Cheng, Shi
AU  - Cheng S
AD  - Medical Research Center, Department of Orthopedics, Guangdong Provincial People's 
      Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
LA  - eng
PT  - Journal Article
DEP - 20220429
PL  - England
TA  - Regen Biomater
JT  - Regenerative biomaterials
JID - 101652150
PMC - PMC9113411
OTO - NOTNLM
OT  - immunomodulation
OT  - nano-magnesium hydroxide
OT  - osteogenesis
OT  - titanium
EDAT- 2022/05/21 06:00
MHDA- 2022/05/21 06:01
PMCR- 2022/04/29
CRDT- 2022/05/20 02:19
PHST- 2021/12/30 00:00 [received]
PHST- 2022/03/30 00:00 [revised]
PHST- 2022/04/17 00:00 [accepted]
PHST- 2022/05/20 02:19 [entrez]
PHST- 2022/05/21 06:00 [pubmed]
PHST- 2022/05/21 06:01 [medline]
PHST- 2022/04/29 00:00 [pmc-release]
AID - rbac027 [pii]
AID - 10.1093/rb/rbac027 [doi]
PST - epublish
SO  - Regen Biomater. 2022 Apr 29;9:rbac027. doi: 10.1093/rb/rbac027. eCollection 2022.