PMID- 35592157
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1664-1078 (Print)
IS  - 1664-1078 (Electronic)
IS  - 1664-1078 (Linking)
VI  - 13
DP  - 2022
TI  - Neural Effects of Cognitive Behavioral Therapy in Psychiatric Disorders: A 
      Systematic Review and Activation Likelihood Estimation Meta-Analysis.
PG  - 853804
LID - 10.3389/fpsyg.2022.853804 [doi]
LID - 853804
AB  - BACKGROUND: Cognitive behavioral therapy (CBT) is a first-line psychotherapeutic 
      treatment that has been recommended for psychiatric disorders. Prior neuroimaging 
      studies have provided preliminary evidence suggesting that CBT can have an impact 
      on the activity of brain regions and functional integration between regions. 
      However, the results are far from conclusive. The present article aimed to detect 
      characteristic changes in brain activation following CBT across psychiatric 
      disorders. METHOD: Web of Science, Cochrane Library, Scopus, and PubMed databases 
      were searched to identify whole-brain functional neuroimaging studies of CBT 
      through 4 August 2021. To be included in the meta-analysis, studies were required 
      to examine functional activation changes between pre-and post-CBT. The included 
      studies were then divided into subgroups according to different task paradigms. 
      Then, an activation likelihood estimation algorithm (ALE) was performed in the 
      different meta-analyses to identify whether brain regions showed consistent 
      effects. Finally, brain regions identified from the meta-analysis were 
      categorized into eight functional networks according to the spatial correlation 
      values between independent components and the template. RESULTS: In total, 13 
      studies met inclusion criteria. Three different meta-analyses were performed 
      separately for total tasks, emotion tasks, and cognition tasks. In the total task 
      ALE meta-analysis, the left precuneus was found to have decreased activation. For 
      the cognition task ALE meta-analysis, left anterior cingulate (ACC) and left 
      middle frontal gyrus (MFG) were found to have decreased activation following CBT. 
      However, the emotion task ALE meta-analysis did not find any specific brain 
      regions showing consistent effects. A review of included studies revealed default 
      mode network (DMN), executive control network (ECN), and salience network (SN) 
      were the most relevant among the eight functional networks. CONCLUSION: The 
      results revealed that the altered activation in the prefrontal cortex and 
      precuneus were key regions related to the effects of CBT. Therefore, CBT may 
      modulate the neural circuitry of emotion regulation. This finding provides 
      recommendations for the rapidly developing literature.
CI  - Copyright (c) 2022 Yuan, Wu, Wu, Xu, Yu, Zhong, Zhang, Li, Xu and Wang.
FAU - Yuan, Shiting
AU  - Yuan S
AD  - Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China.
FAU - Wu, Huiqin
AU  - Wu H
AD  - Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China.
FAU - Wu, Yun
AU  - Wu Y
AD  - School of Psychology, Nanjing Normal University, Nanjing, China.
FAU - Xu, Huazhen
AU  - Xu H
AD  - Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China.
FAU - Yu, Jianping
AU  - Yu J
AD  - Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China.
FAU - Zhong, Yuan
AU  - Zhong Y
AD  - School of Psychology, Nanjing Normal University, Nanjing, China.
FAU - Zhang, Ning
AU  - Zhang N
AD  - Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China.
AD  - Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, China.
AD  - Cognitive Behavioral Therapy Institute of Nanjing Medical University, Nanjing, 
      China.
FAU - Li, Jinyang
AU  - Li J
AD  - Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China.
FAU - Xu, Qianwen
AU  - Xu Q
AD  - School of Psychology, Nanjing Normal University, Nanjing, China.
FAU - Wang, Chun
AU  - Wang C
AD  - Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China.
AD  - School of Psychology, Nanjing Normal University, Nanjing, China.
AD  - Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, China.
AD  - Cognitive Behavioral Therapy Institute of Nanjing Medical University, Nanjing, 
      China.
LA  - eng
PT  - Systematic Review
DEP - 20220503
PL  - Switzerland
TA  - Front Psychol
JT  - Frontiers in psychology
JID - 101550902
PMC - PMC9112423
OTO - NOTNLM
OT  - brain network
OT  - cognitive behavioral therapy (CBT)
OT  - meta-analysis
OT  - neuroimaging
OT  - psychiatric disorder
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/05/21 06:00
MHDA- 2022/05/21 06:01
PMCR- 2022/05/03
CRDT- 2022/05/20 02:19
PHST- 2022/01/13 00:00 [received]
PHST- 2022/03/31 00:00 [accepted]
PHST- 2022/05/20 02:19 [entrez]
PHST- 2022/05/21 06:00 [pubmed]
PHST- 2022/05/21 06:01 [medline]
PHST- 2022/05/03 00:00 [pmc-release]
AID - 10.3389/fpsyg.2022.853804 [doi]
PST - epublish
SO  - Front Psychol. 2022 May 3;13:853804. doi: 10.3389/fpsyg.2022.853804. eCollection 
      2022.