PMID- 35594301
OWN - NLM
STAT- MEDLINE
DCOM- 20220909
LR  - 20221003
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Linking)
VI  - 20
IP  - 7
DP  - 2022 Sep
TI  - Muscle Microcirculatory Responses to Incremental Exercises Are Correlated with 
      Peak Oxygen Uptake in Individuals With and Without Type 2 Diabetes Mellitus.
PG  - 405-413
LID - 10.1089/met.2021.0101 [doi]
AB  - Background: The role of impaired oxygen extraction on peak oxygen uptake 
      (V̇O(2peak)) has been extensively studied using noninvasive and indirect methods 
      in both diabetic patients and healthy participants. Methods: A total of 22 
      participants with type 2 diabetes mellitus [T2DM; median (range) age: 60 (47-70) 
      years] and 22 controls [58 (52-69) years] with no history of diabetes were 
      recruited (reference no. 201812135RINB). Subjects performed an exhaustive 
      incremental exercise and were evaluated using a gas analyzer and near-infrared 
      spectroscopy (NIRS) to determine V̇O(2peak) and changes in muscle oxygenation 
      (SmO(2)) in the vastus lateralis, respectively. Measurements were taken at rest, 
      warm-up, a period during exercise when SmO(2) reached a minimum saturation 
      plateau, and recovery. The microcirculatory responses of the vastus lateralis 
      muscle during incremental exercise in patients with T2DM were compared with those 
      in control individuals, and the correlation between changes in SmO(2) and 
      V̇O(2peak) was estimated. Results: The diabetic group demonstrated lower 
      V̇O(2peak), peak workload, peak heart rate, peak minute ventilation (all 
      P < 0.05), and lower SmO(2) during the rest, warm-up, and recovery phases (all 
      P < 0.05) compared with the control group. A correlation was observed between the 
      change in SmO(2) between the warm-up and plateau value and the V̇O(2peak) 
      (r = 0.608, P = 0.006). Conclusions: The results obtained in this study using 
      NIRS support the feasibility of directly measuring changes in muscle SmO(2) 
      magnitudes to estimate the contributions of peripheral active muscle to systemic 
      O(2) uptake (V̇O(2)) during incremental exercise.
FAU - Lu, Yan-Jhen
AU  - Lu YJ
AD  - School and Graduate Institute of Physical Therapy, College of Medicine, National 
      Taiwan University, Taipei, Taiwan.
AD  - Center of Physical Therapy, National Taiwan University Hospital, Taipei, Taiwan.
FAU - Chen, Ssu-Yuan
AU  - Chen SY
AUID- ORCID: 0000-0002-8025-6211
AD  - Division of Physical Medicine and Rehabilitation, Fu Jen Catholic University 
      Hospital, New Taipei City, Taiwan.
AD  - School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei 
      City, Taiwan.
AD  - Department of Physical Medicine and Rehabilitation, College of Medicine, National 
      Taiwan University, Taipei, Taiwan.
AD  - Department of Physical Medicine and Rehabilitation, National Taiwan University 
      Hospital, Taipei, Taiwan.
FAU - Lai, Ying-Chuen
AU  - Lai YC
AD  - Division of Metabolism and Endocrinology, Department of Internal Medicine, 
      National Taiwan University Hospital, Taipei, Taiwan.
AD  - College of Medicine, National Taiwan University, Taipei, Taiwan.
FAU - Chaiyawat, Pakaratee
AU  - Chaiyawat P
AD  - Faculty of Physical Therapy, Mahidol University, Bangkok, Thailand.
FAU - Chao, Yuan-Hung
AU  - Chao YH
AD  - School and Graduate Institute of Physical Therapy, College of Medicine, National 
      Taiwan University, Taipei, Taiwan.
AD  - Center of Physical Therapy, National Taiwan University Hospital, Taipei, Taiwan.
FAU - Chuang, Lee-Ming
AU  - Chuang LM
AD  - Division of Metabolism and Endocrinology, Department of Internal Medicine, 
      National Taiwan University Hospital, Taipei, Taiwan.
AD  - College of Medicine, National Taiwan University, Taipei, Taiwan.
FAU - Shih, Tiffany Ting-Fang
AU  - Shih TT
AD  - Department of Medical Image and Radiology, Medical College and Hospital, National 
      Taiwan University, Taipei, Taiwan.
FAU - Wang, Hsing-Kuo
AU  - Wang HK
AUID- ORCID: 0000-0001-9199-0721
AD  - School and Graduate Institute of Physical Therapy, College of Medicine, National 
      Taiwan University, Taipei, Taiwan.
AD  - Center of Physical Therapy, National Taiwan University Hospital, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220520
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - *Diabetes Mellitus, Type 2/metabolism
MH  - Exercise Test
MH  - Humans
MH  - Microcirculation
MH  - Middle Aged
MH  - Muscle, Skeletal/metabolism
MH  - Muscles
MH  - Oxygen/metabolism
MH  - *Oxygen Consumption
OTO - NOTNLM
OT  - diabetes mellitus
OT  - incremental exercise
OT  - microcirculation
OT  - peak oxygen uptake
OT  - vastus lateralis
EDAT- 2022/05/21 06:00
MHDA- 2022/09/11 06:00
CRDT- 2022/05/20 13:43
PHST- 2022/05/21 06:00 [pubmed]
PHST- 2022/09/11 06:00 [medline]
PHST- 2022/05/20 13:43 [entrez]
AID - 10.1089/met.2021.0101 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2022 Sep;20(7):405-413. doi: 10.1089/met.2021.0101. 
      Epub 2022 May 20.