PMID- 35594966
OWN - NLM
STAT- MEDLINE
DCOM- 20220620
LR  - 20220621
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 311
DP  - 2022 Aug 15
TI  - Mapping intrinsic functional network topological architecture in major depression 
      disorder after electroconvulsive therapy.
PG  - 103-109
LID - S0165-0327(22)00581-X [pii]
LID - 10.1016/j.jad.2022.05.067 [doi]
AB  - Disrupted topological organization of functional brain networks has been well 
      documented in major depressive disorder (MDD). However, there is no report about 
      how electroconvulsive therapy (ECT), a rapid way for depression remission, 
      affects whole-brain functional network topological architecture to improve 
      clinical symptoms in individuals with MDD. In this study, resting-state 
      functional magnetic resonance imaging (rs-fMRI) data were collected for 
      twenty-four MDD patients before and after receiving ECT and 25 gender-, age- and 
      education-matched healthy controls (HC). The functional brain network for each 
      subject was mapped using Brainnetome Atlas and graph-theory was applied to 
      measure topological properties for both binary and weighted network. The results 
      showed that ECT can significantly increase shortest path length and decrease 
      global efficiency in MDD patients. In addition, significant alterations in nodal 
      degree, nodal efficiency as well as between nodal functional connectivity 
      strength were found in MDD patients after ECT. The network nodes showing changed 
      degree, efficiency and connectivity were primarily distributed in default mode 
      network (DMN), fronto-parietal network (FPN), and limbic system. Our findings 
      demonstrates that ECT improves depressive symptoms by reorganizing disrupted 
      network topological architecture in MDD patients and highlights the important 
      role of functional reorganization of DMN, FPN, and limbic network contributing to 
      depression remission.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Li, Yuanyuan
AU  - Li Y
AD  - School of Life Science and Technology, University of Electronic Science and 
      Technology of China, Chengdu 625014, China.
FAU - Li, Yue
AU  - Li Y
AD  - School of Life Science and Technology, University of Electronic Science and 
      Technology of China, Chengdu 625014, China.
FAU - Wei, Qiang
AU  - Wei Q
AD  - Department of Neurology, the First Hospital of Anhui Medical University, Hefei 
      230022, China.
FAU - Bai, Tongjian
AU  - Bai T
AD  - Department of Neurology, the First Hospital of Anhui Medical University, Hefei 
      230022, China.
FAU - Wang, Kai
AU  - Wang K
AD  - Department of Neurology, the First Hospital of Anhui Medical University, Hefei 
      230022, China; Anhui Province Key Laboratory of Cognition and Neuropsychiatric 
      Disorders, Hefei 230022, China; Anhui Medical University, School of Mental Health 
      and Psychological Sciences, Hefei 230022, China; Collaborative Innovation Center 
      of Neuropsychiatric Disorders and Mental Health, Hefei 230022, China; Anhui 
      Province clinical research center for neurological disease, Hefei 230022, China.
FAU - Wang, Jiaojian
AU  - Wang J
AD  - School of Life Science and Technology, University of Electronic Science and 
      Technology of China, Chengdu 625014, China; Key Laboratory of Biorheological 
      Science and Technology, Ministry of Education, College of Bioengineering, 
      Chongqing University, Chongqing 400030, China. Electronic address: 
      jiaojianwang@uestc.edu.cn.
FAU - Tian, Yanghua
AU  - Tian Y
AD  - Department of Neurology, the First Hospital of Anhui Medical University, Hefei 
      230022, China; Anhui Province Key Laboratory of Cognition and Neuropsychiatric 
      Disorders, Hefei 230022, China; Anhui Medical University, School of Mental Health 
      and Psychological Sciences, Hefei 230022, China; Collaborative Innovation Center 
      of Neuropsychiatric Disorders and Mental Health, Hefei 230022, China; Anhui 
      Province clinical research center for neurological disease, Hefei 230022, China; 
      Institute of Artificial Intelligence, Hefei Comprehensive National Science 
      Center, Hefei 230022, China. Electronic address: ayfytyh@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220518
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Brain
MH  - Brain Mapping
MH  - Depression
MH  - *Depressive Disorder, Major/diagnostic imaging/pathology/therapy
MH  - *Electroconvulsive Therapy
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Neural Pathways
OTO - NOTNLM
OT  - Brain network
OT  - Brainnetome atlas
OT  - Electroconvulsive therapy
OT  - Graph theory
OT  - Major depressive disorder
EDAT- 2022/05/21 06:00
MHDA- 2022/06/22 06:00
CRDT- 2022/05/20 19:24
PHST- 2022/02/08 00:00 [received]
PHST- 2022/04/07 00:00 [revised]
PHST- 2022/05/12 00:00 [accepted]
PHST- 2022/05/21 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2022/05/20 19:24 [entrez]
AID - S0165-0327(22)00581-X [pii]
AID - 10.1016/j.jad.2022.05.067 [doi]
PST - ppublish
SO  - J Affect Disord. 2022 Aug 15;311:103-109. doi: 10.1016/j.jad.2022.05.067. Epub 
      2022 May 18.