PMID- 35595078
OWN - NLM
STAT- MEDLINE
DCOM- 20221024
LR  - 20230124
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 364
IP  - 5
DP  - 2022 Nov
TI  - Prediabetes versus type 2 diabetes in patients with acute myocardial infarction 
      and current smoking.
PG  - 612-623
LID - S0002-9629(22)00238-5 [pii]
LID - 10.1016/j.amjms.2022.05.016 [doi]
AB  - BACKGROUND: Smoking is linked with increased risk of cardiovascular events among 
      diabetic patients. Prediabetes is associated with increased risk for 
      microvascular and macrovascular complications. We compared the 2-year clinical 
      outcomes of current smoking between prediabetic and type 2 diabetes mellitus 
      (T2DM) patients with acute myocardial infarction (AMI) after newer-generation 
      drug-eluting stent (DES) implantation. METHODS: A total of 5161 AMI patients who 
      were currently smoking were classified into normoglycemia (group A: 1,416), 
      prediabetes (group B: 1,740), and T2DM (group C: 2,005) groups. The primary 
      endpoint was major adverse cardiac events (MACEs), defined as all-cause death, 
      recurrent myocardial infarction and any repeat revascularization. The secondary 
      endpoint was the occurrence of stent thrombosis (ST) and stroke. RESULTS: The 
      cumulative incidences of all primary and secondary endpoints including MACEs 
      (adjusted hazard ratio [aHR]: 1.150; 95% confidence interval [CI]: 0.891-1.484; 
      P = 0.284), ST, and stroke were similar between group B and group C. The 
      cumulative incidences of MACEs (aHR: 1.385; 95% CI: 1.007-1.904; P = 0.045) and 
      all-cause death or MI were significantly higher in group B than in group A. The 
      cumulative incidences of MACEs (aHR: 1.572; 95% CI: 1.157-2.137; P = 0.004), 
      all-cause death, Re-MI, and all-cause death or MI were significantly higher in 
      group C than in group A. CONCLUSIONS: Current smoking leads to worse clinical 
      outcomes in patients with AMI and prediabetes, and thus, similarly to T2DM 
      patients, more attention and more intensive treatment strategy including quitting 
      smoking would be advantageous.
CI  - Copyright (c) 2022 Southern Society for Clinical Investigation. Published by 
      Elsevier Inc. All rights reserved.
FAU - Kim, Yong Hoon
AU  - Kim YH
AD  - Division of Cardiology, Department of Internal Medicine, Kangwon National 
      University School of Medicine, Chuncheon, Republic of Korea. Electronic address: 
      yhkim02@kangwon.ac.kr.
FAU - Her, Ae-Young
AU  - Her AY
AD  - Division of Cardiology, Department of Internal Medicine, Kangwon National 
      University School of Medicine, Chuncheon, Republic of Korea.
FAU - Jeong, Myung Ho
AU  - Jeong MH
AD  - Department of Cardiology, Cardiovascular Center, Chonnam National University 
      Hospital, Gwangju, Republic of Korea.
FAU - Kim, Byeong-Keuk
AU  - Kim BK
AD  - Division of Cardiology Severance Cardiovascular Hospital, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Hong, Sung-Jin
AU  - Hong SJ
AD  - Division of Cardiology Severance Cardiovascular Hospital, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Kim, Seunghwan
AU  - Kim S
AD  - Division of Cardiology, Inje University College of Medicine, Haeundae Paik 
      Hospital, Busan, Republic of Korea.
FAU - Ahn, Chul-Min
AU  - Ahn CM
AD  - Division of Cardiology Severance Cardiovascular Hospital, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Kim, Jung-Sun
AU  - Kim JS
AD  - Division of Cardiology Severance Cardiovascular Hospital, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Ko, Young-Guk
AU  - Ko YG
AD  - Division of Cardiology Severance Cardiovascular Hospital, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Choi, Donghoon
AU  - Choi D
AD  - Division of Cardiology Severance Cardiovascular Hospital, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Hong, Myeong-Ki
AU  - Hong MK
AD  - Division of Cardiology Severance Cardiovascular Hospital, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Jang, Yangsoo
AU  - Jang Y
AD  - Division of Cardiology Severance Cardiovascular Hospital, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220517
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
SB  - IM
MH  - Humans
MH  - *Drug-Eluting Stents/adverse effects
MH  - *Prediabetic State/complications/epidemiology
MH  - *Percutaneous Coronary Intervention/adverse effects
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - *Myocardial Infarction/complications
MH  - Smoking/adverse effects/epidemiology
MH  - *Thrombosis/complications
MH  - *Stroke/etiology
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Diabetes
OT  - myocardial infarction
OT  - prediabetes
OT  - smoking
COIS- Conflict of Interest Statement The authors have no financial or other conflicts 
      of interest to disclose.
EDAT- 2022/05/21 06:00
MHDA- 2022/10/25 06:00
CRDT- 2022/05/20 19:33
PHST- 2020/07/31 00:00 [received]
PHST- 2021/09/13 00:00 [revised]
PHST- 2022/05/12 00:00 [accepted]
PHST- 2022/05/21 06:00 [pubmed]
PHST- 2022/10/25 06:00 [medline]
PHST- 2022/05/20 19:33 [entrez]
AID - S0002-9629(22)00238-5 [pii]
AID - 10.1016/j.amjms.2022.05.016 [doi]
PST - ppublish
SO  - Am J Med Sci. 2022 Nov;364(5):612-623. doi: 10.1016/j.amjms.2022.05.016. Epub 
      2022 May 17.