PMID- 35595804
OWN - NLM
STAT- MEDLINE
DCOM- 20220524
LR  - 20220716
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 May 20
TI  - The effect of intermittent pneumatic compression on deep-vein thrombosis and 
      ventilation-free days in critically ill patients with heart failure.
PG  - 8519
LID - 10.1038/s41598-022-12336-9 [doi]
LID - 8519
AB  - There are contradictory data regarding the effect of intermittent pneumatic 
      compression (IPC) on the incidence of deep-vein thrombosis (DVT) and heart 
      failure (HF) decompensation in critically ill patients. This study evaluated the 
      effect of adjunctive use of IPC on the rate of incident DVT and ventilation-free 
      days among critically ill patients with HF. In this pre-specified secondary 
      analysis of the PREVENT trial (N = 2003), we compared the effect of adjunctive 
      IPC added to pharmacologic thromboprophylaxis (IPC group), with pharmacologic 
      thromboprophylaxis alone (control group) in critically ill patients with HF. The 
      presence of HF was determined by the treating teams according to local practices. 
      Patients were stratified according to preserved (>/= 40%) versus reduced (< 40%) 
      left ventricular ejection fraction, and by the New York Heart Association (NYHA) 
      classification. The primary outcome was incident proximal lower-limb DVT, 
      determined with twice weekly venous Doppler ultrasonography. As a co-primary 
      outcome, we evaluated ventilation-free days as a surrogate for clinically 
      important HF decompensation. Among 275 patients with HF, 18 (6.5%) patients had 
      prevalent proximal lower-limb DVT (detected on trial day 1 to 3). Of 257 patients 
      with no prevalent DVT, 11/125 (8.8%) patients in the IPC group developed incident 
      proximal lower-limb DVT compared to 6/132 (4.5%) patients in the control group 
      (relative risk, 1.94; 95% confidence interval, 0.74-5.08, p = 0.17). There was no 
      significant difference in ventilator-free days between the IPC and control groups 
      (median 21 days versus 25 days respectively, p = 0.17). The incidence of DVT with 
      IPC versus control was not different across NYHA classes (p value for 
      interaction = 0.18), nor across patients with reduced and preserved ejection 
      fraction (p value for interaction = 0.15). Ventilator-free days with IPC versus 
      control were also not different across NYHA classes nor across patients with 
      reduced or preserved ejection fraction. In conclsuion, the use of adjunctive IPC 
      compared with control was associated with similar rate of incident proximal 
      lower-limb DVT and ventilator-free days in critically ill patients with HF.Trial 
      registration: The PREVENT trial is registered at ClinicalTrials.gov, ID: 
      NCT02040103 (registered on 3 November 2013, 
      https://clinicaltrials.gov/ct2/show/study/NCT02040103 ) and Current controlled 
      trials, ID: ISRCTN44653506 (registered on 30 October 2013).
CI  - (c) 2022. The Author(s).
FAU - Al-Dorzi, Hasan M
AU  - Al-Dorzi HM
AD  - Intensive Care Department, Ministry of National Guard Health Affairs, Riyadh, 
      Kingdom of Saudi Arabia.
AD  - King Abdullah International Medical Research Center, Riyadh, Kingdom of Saudi 
      Arabia.
AD  - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, 
      Riyadh, Kingdom of Saudi Arabia.
FAU - Al-Dawood, Abdulaziz
AU  - Al-Dawood A
AD  - Intensive Care Department, Ministry of National Guard Health Affairs, Riyadh, 
      Kingdom of Saudi Arabia.
AD  - King Abdullah International Medical Research Center, Riyadh, Kingdom of Saudi 
      Arabia.
AD  - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, 
      Riyadh, Kingdom of Saudi Arabia.
FAU - Al-Hameed, Fahad M
AU  - Al-Hameed FM
AD  - Intensive Care Department, Ministry of National Guard Health Affairs, Jeddah, 
      Kingdom of Saudi Arabia.
AD  - King Abdullah International Medical Research Center Jeddah, King Saud Bin 
      Abdulaziz University for Health Sciences, Jeddah, Kingdom of Saudi Arabia.
FAU - Burns, Karen E A
AU  - Burns KEA
AD  - Interdepartmental Division of Critical Care Medicine, University of Toronto, 
      Toronto, Canada.
AD  - Unity Health Toronto - St Michael's Hospital, Toronto, Canada.
AD  - Li Ka Shing Knowledge Institute, Toronto, Canada.
FAU - Mehta, Sangeeta
AU  - Mehta S
AD  - Department of Medicine, Medical Surgical ICU, Mount Sinai Hospital, University of 
      Toronto, Toronto, Canada.
FAU - Jose, Jesna
AU  - Jose J
AD  - Department Biostatistics and Bioinformatics, King Abdullah International Medical 
      Research Center, Riyadh, Kingdom of Saudi Arabia.
AD  - King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi 
      Arabia.
FAU - Alsolamy, Sami
AU  - Alsolamy S
AD  - Intensive Care Department, Ministry of National Guard Health Affairs, Riyadh, 
      Kingdom of Saudi Arabia.
AD  - King Abdullah International Medical Research Center, Riyadh, Kingdom of Saudi 
      Arabia.
AD  - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, 
      Riyadh, Kingdom of Saudi Arabia.
FAU - Abdukahil, Sheryl Ann I
AU  - Abdukahil SAI
AD  - Intensive Care Department, Ministry of National Guard Health Affairs, Riyadh, 
      Kingdom of Saudi Arabia.
AD  - King Abdullah International Medical Research Center, Riyadh, Kingdom of Saudi 
      Arabia.
AD  - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, 
      Riyadh, Kingdom of Saudi Arabia.
FAU - Afesh, Lara Y
AU  - Afesh LY
AD  - King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi 
      Arabia.
AD  - Research Office, King Abdullah International Medical Research Center, Riyadh, 
      Kingdom of Saudi Arabia.
FAU - Alshahrani, Mohammed S
AU  - Alshahrani MS
AD  - Department of Emergency and Critical Care Medicine, College of Medicine, King 
      Fahd Hospital of the University-Imam Abdulrahman Bin Faisal University, Dammam, 
      Kingdom of Saudi Arabia.
FAU - Mandourah, Yasser
AU  - Mandourah Y
AD  - Military Medical Services, Ministry of Defense, Riyadh, Kingdom of Saudi Arabia.
FAU - Almekhlafi, Ghaleb A
AU  - Almekhlafi GA
AD  - Department of Intensive Care Services, Prince Sultan Military Medical City, 
      Riyadh, Kingdom of Saudi Arabia.
FAU - Almaani, Mohammed
AU  - Almaani M
AD  - Department of Pulmonary and Critical Care Medicine, King Fahad Medical City, 
      Riyadh, Kingdom of Saudi Arabia.
FAU - Al Bshabshe, Ali
AU  - Al Bshabshe A
AD  - Department of Critical Care Medicine, Asir Central Hospital, King Khalid 
      University, Abha, Kingdom of Saudi Arabia.
FAU - Finfer, Simon
AU  - Finfer S
AD  - The George Institute for Global Health, University of New South Wales, Sydney, 
      Australia.
FAU - Arshad, Zia
AU  - Arshad Z
AD  - Department of Anesthesiology and Critical Care, King George's Medical University, 
      Lucknow, India.
FAU - Khalid, Imran
AU  - Khalid I
AD  - Critical Care Section, Department of Medicine, King Faisal Specialist Hospital 
      and Research Center, Jeddah, Kingdom of Saudi Arabia.
FAU - Mehta, Yatin
AU  - Mehta Y
AD  - Institute of Critical Care and Anaesthesiology, Medanta - The Medicity, Gurgaon, 
      Haryana, India.
FAU - Gaur, Atul
AU  - Gaur A
AD  - Intensive Care Department, Gosford Hospital, Gosford, New South Wales, Australia.
FAU - Hawa, Hassan
AU  - Hawa H
AD  - Critical Care Medicine Department, King Faisal Specialist Hospital and Research 
      Centre, Riyadh, Kingdom of Saudi Arabia.
FAU - Buscher, Hergen
AU  - Buscher H
AD  - Department of Intensive Care Medicine, Centre for Applied Medical Research, St. 
      Vincent's Hospital, University of New South Wales, Sydney, Australia.
FAU - Lababidi, Hani
AU  - Lababidi H
AD  - Department of Pulmonary and Critical Care Medicine, King Fahad Medical City, 
      Riyadh, Kingdom of Saudi Arabia.
FAU - Al Aithan, Abdulsalam
AU  - Al Aithan A
AD  - Intensive Care Division, Department of Medicine, King Abdulaziz Hospital, King 
      Abdullah International Medical Research Center, King Saud Bin Abdulaziz 
      University for Health Sciences, Al Ahsa, Kingdom of Saudi Arabia.
FAU - Arabi, Yaseen M
AU  - Arabi YM
AD  - Intensive Care Department, Ministry of National Guard Health Affairs, Riyadh, 
      Kingdom of Saudi Arabia. yaseenarabi@yahoo.com.
AD  - King Abdullah International Medical Research Center, Riyadh, Kingdom of Saudi 
      Arabia. yaseenarabi@yahoo.com.
AD  - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, 
      Riyadh, Kingdom of Saudi Arabia. yaseenarabi@yahoo.com.
LA  - eng
SI  - ClinicalTrials.gov/NCT02040103
SI  - ISRCTN/ISRCTN44653506
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220520
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Anticoagulants)
SB  - IM
MH  - Anticoagulants/therapeutic use
MH  - Critical Illness/therapy
MH  - *Heart Failure/drug therapy/therapy
MH  - Humans
MH  - Intermittent Pneumatic Compression Devices
MH  - Stroke Volume
MH  - *Venous Thromboembolism/epidemiology
MH  - *Venous Thrombosis/drug therapy/prevention & control
MH  - Ventricular Function, Left
PMC - PMC9122920
COIS- The authors declare no competing interests.
EDAT- 2022/05/21 06:00
MHDA- 2022/05/25 06:00
PMCR- 2022/05/20
CRDT- 2022/05/20 23:19
PHST- 2021/10/31 00:00 [received]
PHST- 2022/05/03 00:00 [accepted]
PHST- 2022/05/20 23:19 [entrez]
PHST- 2022/05/21 06:00 [pubmed]
PHST- 2022/05/25 06:00 [medline]
PHST- 2022/05/20 00:00 [pmc-release]
AID - 10.1038/s41598-022-12336-9 [pii]
AID - 12336 [pii]
AID - 10.1038/s41598-022-12336-9 [doi]
PST - epublish
SO  - Sci Rep. 2022 May 20;12(1):8519. doi: 10.1038/s41598-022-12336-9.