PMID- 35596008
OWN - NLM
STAT- MEDLINE
DCOM- 20220913
LR  - 20220921
IS  - 1436-6215 (Electronic)
IS  - 1436-6207 (Linking)
VI  - 61
IP  - 7
DP  - 2022 Oct
TI  - The effects of sesame, canola, and sesame-canola oils on cardiometabolic markers 
      in patients with type 2 diabetes: a triple-blind three-way randomized crossover 
      clinical trial.
PG  - 3499-3516
LID - 10.1007/s00394-022-02898-9 [doi]
AB  - AIMS: To compare the effects of replacing regular dietary oils intake with sesame 
      (SO), canola (CO), and sesame-canola (SCO) oils (a novel blend), on 
      cardiometabolic markers in adults with type 2 diabetes mellitus (T2DM), in a 
      triple-blind, three-way, randomized, crossover clinical trial. METHODS: 
      Participants were assigned to receive SO, CO, and SCO in three 9-week phases 
      (4 weeks apart). Cardiometabolic makers (serum lipids, Apolipoprotein, 
      cardiovascular risk scores, kidney markers, and blood pressure) were considered 
      at the beginning and the end of intervention phases. RESULTS: Ninety-two, 
      ninety-five, and ninety-five participants completed the SO, SCO, and CO periods, 
      respectively. After CO consumption, serum Apo A-1 concentrations were 
      significantly higher compared with the SCO period in the whole population 
      (p < 0.05). A considerable reduction in visceral adiposity index values was seen 
      in the CO compared with the SO period in males (p < 0.05). Serum high-density 
      lipoprotein concentration was also significantly higher after the SO intake 
      compared with SCO in females (p < 0.05). The between-period analysis showed a 
      substantial reduction in diastolic blood pressure in the SCO period compared with 
      the CO and SO periods and lower systolic blood pressure after SCO versus CO 
      intake in males (p < 0.05). CONCLUSIONS: Canola oil might protect CVD through 
      improving Apo A-1 levels in patients with T2DM (particularly in females) and 
      visceral adiposity index in male patients. However, the blend oil might 
      beneficially affect blood pressure in men. Future sex-specific studies might 
      warrant the current findings. REGISTRY OF CLINICAL TRIALS: This trial was 
      registered in the Iranian Registry of Clinical Trials (IRCT, registration ID: 
      IRCT2016091312571N6).
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
FAU - Amiri, Mojgan
AU  - Amiri M
AD  - Nutrition and Food Security Research Center, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
AD  - Department of Nutrition, School of Public Health, Shahid Sadoughi University of 
      Medical Sciences, Yazd, PO Code 8915173160, Iran.
FAU - Raeisi-Dehkordi, Hamidreza
AU  - Raeisi-Dehkordi H
AD  - Nutrition and Food Security Research Center, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
AD  - Department of Nutrition, School of Public Health, Shahid Sadoughi University of 
      Medical Sciences, Yazd, PO Code 8915173160, Iran.
FAU - Moghtaderi, Fatemeh
AU  - Moghtaderi F
AD  - Nutrition and Food Security Research Center, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
AD  - Department of Nutrition, School of Public Health, Shahid Sadoughi University of 
      Medical Sciences, Yazd, PO Code 8915173160, Iran.
FAU - Zimorovat, Alireza
AU  - Zimorovat A
AD  - Nutrition and Food Security Research Center, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
AD  - Department of Nutrition, School of Public Health, Shahid Sadoughi University of 
      Medical Sciences, Yazd, PO Code 8915173160, Iran.
FAU - Mohyadini, Matin
AU  - Mohyadini M
AD  - Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, 
      Iran.
AD  - Department of Medical Laboratory Sciences, School of Para Medicine, Shahid 
      Sadoughi University of Medical Sciences, Yazd, Iran.
FAU - Salehi-Abargouei, Amin
AU  - Salehi-Abargouei A
AUID- ORCID: 0000-0002-7580-6717
AD  - Nutrition and Food Security Research Center, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran. abargouei@ssu.ac.ir.
AD  - Department of Nutrition, School of Public Health, Shahid Sadoughi University of 
      Medical Sciences, Yazd, PO Code 8915173160, Iran. abargouei@ssu.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20220521
PL  - Germany
TA  - Eur J Nutr
JT  - European journal of nutrition
JID - 100888704
RN  - 0 (Apolipoprotein A-I)
RN  - 0 (Biomarkers)
RN  - 0 (Plant Oils)
RN  - 0 (Rapeseed Oil)
RN  - 8008-74-0 (Sesame Oil)
SB  - IM
MH  - Adult
MH  - Apolipoprotein A-I
MH  - Biomarkers
MH  - *Cardiovascular Diseases/prevention & control
MH  - Cross-Over Studies
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Female
MH  - Humans
MH  - Iran
MH  - Male
MH  - Obesity, Abdominal
MH  - *Plant Oils/pharmacology
MH  - Rapeseed Oil
MH  - Sesame Oil
OTO - NOTNLM
OT  - Apolipoprotein
OT  - Canola oil
OT  - Cardiovascular risk factors
OT  - Dietary oils
OT  - Dyslipidemia
OT  - Hypertension
OT  - Lipids
OT  - Lipoproteins
OT  - Rapeseed oil
OT  - Sesame oil
OT  - Type 2 diabetes mellitus
EDAT- 2022/05/21 06:00
MHDA- 2022/09/14 06:00
CRDT- 2022/05/20 23:29
PHST- 2021/04/07 00:00 [received]
PHST- 2022/04/22 00:00 [accepted]
PHST- 2022/05/21 06:00 [pubmed]
PHST- 2022/09/14 06:00 [medline]
PHST- 2022/05/20 23:29 [entrez]
AID - 10.1007/s00394-022-02898-9 [pii]
AID - 10.1007/s00394-022-02898-9 [doi]
PST - ppublish
SO  - Eur J Nutr. 2022 Oct;61(7):3499-3516. doi: 10.1007/s00394-022-02898-9. Epub 2022 
      May 21.