PMID- 35596100
OWN - NLM
STAT- MEDLINE
DCOM- 20220817
LR  - 20220908
IS  - 1534-6315 (Electronic)
IS  - 1529-7322 (Linking)
VI  - 22
IP  - 9
DP  - 2022 Sep
TI  - Alpha-1 Asthma Overlap Syndrome: a Clinical Overview.
PG  - 101-111
LID - 10.1007/s11882-022-01036-z [doi]
AB  - PURPOSE OF REVIEW: Alpha-1 antitrypsin deficiency (AATD) is one of the most 
      common genetic diseases that is associated with severe complications and yet 
      remains underdiagnosed. The pulmonary symptoms of both AATD and asthma include 
      cough, excessive sputum production, dyspnea, and wheezing. These symptoms overlap 
      significantly leading to difficulty distinguishing between these two conditions 
      and suspicion that there may be an overlap syndrome. We aim to discuss the 
      pathophysiology, clinical manifestations, and treatment of both alpha-1 
      antitrypsin and asthma and how they may overlap. RECENT FINDINGS: Recent 
      literature suggests that there is an association between asthma and AATD. This 
      association has been hypothesized to be secondary to an imbalance of elastase and 
      anti-elastase leading to a pro-inflammatory state in patients with AATD. This 
      review serves to overview the pathophysiology, clinical manifestations, and 
      treatment of alpha-1 antitrypsin, asthma, and the increasingly recognized 
      intersection of the two, AATD-asthma overlap syndrome.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Izquierdo, Manuel
AU  - Izquierdo M
AD  - Department of Internal Medicine, Section On Pulmonary, Critical Care, 
      Immunologic, and Asthma Medicine, Wake Forest Baptist Hospital, 1 Medical Center 
      Blvd, Winston-Salem, NC, 27157, USA. mizquier@wakehealth.edu.
FAU - Rawal, Himanshu
AU  - Rawal H
AD  - Department of Internal Medicine, Section On Pulmonary, Critical Care, 
      Immunologic, and Asthma Medicine, Wake Forest Baptist Hospital, 1 Medical Center 
      Blvd, Winston-Salem, NC, 27157, USA.
FAU - Armstrong, Michael
AU  - Armstrong M
AD  - Department of Internal Medicine, Wake Forest Baptist Hospital, 1 Medical Center 
      Blvd, Winston-Salem, NC, 27157, USA.
FAU - Marion, Chad R
AU  - Marion CR
AUID- ORCID: 0000-0002-7923-0890
AD  - Department of Internal Medicine, Section On Pulmonary, Critical Care, 
      Immunologic, and Asthma Medicine, Wake Forest Baptist Hospital, 1 Medical Center 
      Blvd, Winston-Salem, NC, 27157, USA. Crmarion@wakehealth.edu.
AD  - Department On Internal Medicine, Section On Pulmonary, Critical Care and Sleep 
      Medicine, W. G. (Bill) Hefner Veterans Affairs Medical Center, Salisbury, NC, 
      USA. Crmarion@wakehealth.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220520
PL  - United States
TA  - Curr Allergy Asthma Rep
JT  - Current allergy and asthma reports
JID - 101096440
RN  - 0 (alpha 1-Antitrypsin)
SB  - IM
MH  - *Asthma/complications/diagnosis/therapy
MH  - Humans
MH  - Lung
MH  - *Lung Diseases/drug therapy
MH  - *Pulmonary Disease, Chronic Obstructive/therapy
MH  - Syndrome
MH  - alpha 1-Antitrypsin/genetics/therapeutic use
MH  - *alpha 1-Antitrypsin Deficiency/complications/diagnosis/genetics
OTO - NOTNLM
OT  - AAT
OT  - AATD
OT  - Alpha-1 antitrypsin deficiency
OT  - Alpha-1 asthma overlap syndrome
OT  - Asthma
EDAT- 2022/05/21 06:00
MHDA- 2022/08/18 06:00
CRDT- 2022/05/20 23:33
PHST- 2022/04/13 00:00 [accepted]
PHST- 2022/05/21 06:00 [pubmed]
PHST- 2022/08/18 06:00 [medline]
PHST- 2022/05/20 23:33 [entrez]
AID - 10.1007/s11882-022-01036-z [pii]
AID - 10.1007/s11882-022-01036-z [doi]
PST - ppublish
SO  - Curr Allergy Asthma Rep. 2022 Sep;22(9):101-111. doi: 10.1007/s11882-022-01036-z. 
      Epub 2022 May 20.