PMID- 35596602 OWN - NLM STAT- MEDLINE DCOM- 20220706 LR - 20220718 IS - 1447-0756 (Electronic) IS - 1341-8076 (Linking) VI - 48 IP - 7 DP - 2022 Jul TI - HE4 is associated with clinical risk prognostic factors and survival outcome in primary fallopian tube carcinoma patients. PG - 1897-1903 LID - 10.1111/jog.15293 [doi] AB - AIM: To explore whether HE4 was associated with clinical risk prognostic factors and survival outcome in primary fallopian tube carcinoma patients. METHODS: Ninety-six primary fallopian tube carcinoma (PFTC) patients from March 2011 to June 2019 were enrolled in this study. Serum CA125 and HE4 concentrations were measured at four time points including primary diagnosis, postsurgery, pre-recurrence, and recurrence. The relations between clinical risk prognostic factors with HE4 concentrations were investigated, and multivariate survival analysis was used to calculate the hazard ratios between HE4 levels with recurrence-free survival and overall survival. RESULTS: HE4 were significantly elevated in poor performance status, advanced stage, high histological grade and residual tumor diameter >1 cm, and positive lymph node status, respectively, compared with those in well performance status, early stage, low histological grade, residual tumor diameter