PMID- 35597397
OWN - NLM
STAT- MEDLINE
DCOM- 20220615
LR  - 20220615
IS  - 1095-9947 (Electronic)
IS  - 1050-4648 (Linking)
VI  - 126
DP  - 2022 Jul
TI  - Toxic effects of polystyrene nanoplastics and polybrominated diphenyl ethers to 
      zebrafish (Danio rerio).
PG  - 21-33
LID - S1050-4648(22)00266-2 [pii]
LID - 10.1016/j.fsi.2022.05.025 [doi]
AB  - Nanoplastics (NPs) are good carriers of persistent organic pollutants (POPs) such 
      as polybrominated diphenyl ethers (PBDEs), and can alter their bioavailability 
      and toxic impacts to aquatic organisms. This study highlights the single and 
      combined toxic effects of polystyrene nanoplastics (PS-NPs) and 
      2,2',4,4'-tetrabromodiphenyl ether (BDE-47, one of the dominant congeners of 
      PBDEs) on zebrafish embryos after an exposure duration of up to 120 hpf. Results 
      showed that PS-NPs and BDE-47 co-exposure exacerbated the morphological 
      deformities in terms of pericardial edema, yolk sac edema and curved tail in 
      zebrafish larvae. Compared to BDE-47 single exposure, the combined exposure 
      caused lower survival rates, shorter body lengths, and accelerated spontaneous 
      movements. Further, PS-NPs were quickly aggregated on the surface of the 
      embryonic chorions covered almost the entire membrane at 12 and 48 hpf, and 
      concentration dependent accumulation was also found in the brain, mouth, trunk, 
      gills, heart, liver and gastrointestinal tract at the larval stages. During the 
      recovery period (7 days), PS-NPs were released from all the organs, with the 
      highest elimination from the gastrointestinal tract. Histopathological 
      examination revealed that co-exposure caused greater damage to retinal 
      structures, muscle fibers and cartilage tissues. Responses of 
      hypothalamic-pituitary-thyroid axis (CRH, TSHbeta, NIS, TTR, Dio2, TG, TRalpha and TRbeta) 
      and reproduction (Esr2 and Vtg1) related genes were also investigated, and 
      results showed that the co-exposure induced more significant upregulated 
      expressions of TSHbeta, TG, Doi 2, and TRbeta, compared to BDE-47 single exposure. In 
      conclusion, co-exposure to NPs and BDE-47 exacerbated developmental and thyroid 
      toxicity in zebrafish, generally elucidating the toxicological effects mediated 
      by complex chemical interactions between NPs with POPs in the freshwater 
      environment.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Wang, Qiuping
AU  - Wang Q
AD  - College of Marine Sciences, South China Agricultural University, Guangzhou, 
      510642, China.
FAU - Li, Yizheng
AU  - Li Y
AD  - College of Marine Sciences, South China Agricultural University, Guangzhou, 
      510642, China.
FAU - Chen, Yurou
AU  - Chen Y
AD  - College of Marine Sciences, South China Agricultural University, Guangzhou, 
      510642, China.
FAU - Tian, Liyan
AU  - Tian L
AD  - College of Marine Sciences, South China Agricultural University, Guangzhou, 
      510642, China.
FAU - Gao, Dandan
AU  - Gao D
AD  - College of Marine Sciences, South China Agricultural University, Guangzhou, 
      510642, China.
FAU - Liao, Hongping
AU  - Liao H
AD  - College of Marine Sciences, South China Agricultural University, Guangzhou, 
      510642, China.
FAU - Kong, Chunmiao
AU  - Kong C
AD  - College of Marine Sciences, South China Agricultural University, Guangzhou, 
      510642, China.
FAU - Chen, Xikun
AU  - Chen X
AD  - College of Marine Sciences, South China Agricultural University, Guangzhou, 
      510642, China.
FAU - Junaid, Muhammad
AU  - Junaid M
AD  - College of Marine Sciences, South China Agricultural University, Guangzhou, 
      510642, China.
FAU - Wang, Jun
AU  - Wang J
AD  - College of Marine Sciences, South China Agricultural University, Guangzhou, 
      510642, China; Institute of Eco-Environmental Research, Guangxi Academy of 
      Sciences, Nanning, 530007, China; Southern Marine Science and Engineering 
      Guangdong Laboratory (Zhuhai), Guangzhou, 510006, China. Electronic address: 
      wangjun2016@scau.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220519
PL  - England
TA  - Fish Shellfish Immunol
JT  - Fish & shellfish immunology
JID - 9505220
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Microplastics)
RN  - 0 (Polystyrenes)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Animals
MH  - Embryo, Nonmammalian
MH  - *Halogenated Diphenyl Ethers/metabolism/toxicity
MH  - Larva/genetics
MH  - Microplastics/toxicity
MH  - Polystyrenes/toxicity
MH  - *Water Pollutants, Chemical/metabolism/toxicity
MH  - Zebrafish/genetics
OTO - NOTNLM
OT  - BDE-47
OT  - Developmental impacts
OT  - Hypothalamic-pituitary-thyroid axis
OT  - Polystyrene nanoplastics
OT  - Zebrafish
EDAT- 2022/05/22 06:00
MHDA- 2022/06/16 06:00
CRDT- 2022/05/21 19:25
PHST- 2022/04/26 00:00 [received]
PHST- 2022/05/11 00:00 [revised]
PHST- 2022/05/12 00:00 [accepted]
PHST- 2022/05/22 06:00 [pubmed]
PHST- 2022/06/16 06:00 [medline]
PHST- 2022/05/21 19:25 [entrez]
AID - S1050-4648(22)00266-2 [pii]
AID - 10.1016/j.fsi.2022.05.025 [doi]
PST - ppublish
SO  - Fish Shellfish Immunol. 2022 Jul;126:21-33. doi: 10.1016/j.fsi.2022.05.025. Epub 
      2022 May 19.