PMID- 35597461
OWN - NLM
STAT- MEDLINE
DCOM- 20220628
LR  - 20220628
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 303
IP  - Pt 1
DP  - 2022 Sep
TI  - Exposure to several polychlorinated biphenyls (PCBs) is associated with chronic 
      kidney disease among general adults: Korean National Environmental Health Survey 
      (KoNEHS) 2015-2017.
PG  - 134998
LID - S0045-6535(22)01491-6 [pii]
LID - 10.1016/j.chemosphere.2022.134998 [doi]
AB  - We investigated the association between major persistent organic pollutants 
      (POPs) exposure and chronic kidney disease (CKD) among general adult population 
      of Korea. For this purpose, a subset of the adult population (n = 1276) 
      participated in Korean National Environmental Health Survey (KoNEHS) Cycle 3 
      (2015-2017) were analyzed for twenty-four POPs in serum, including organochlorine 
      pesticides (OCPs), polychlorinated biphenyls (PCBs), and polybrominated diphenyl 
      ethers (PBDEs), and were derived for estimated glomerular filtration rate (eGFR) 
      and urinary albumin-to-creatinine ratio (uACR). Multivariable linear regression 
      was conducted to assess the association between POPs exposure and CKD-related 
      parameters including eGFR and uACR. As sensitivity analyses, principal component 
      analysis was conducted. Moreover, the U.S. National Health and Nutrition 
      Examination Survey (NHANES) 1999-2004 data were chosen to compare with the 
      observations of the Korean adults. Approximately 7.7% of the Korean adult 
      population possessed CKD based on either eGFR (<60 ml/min/1.73 m(2)) or uACR 
      (>/=30 mg/g) criteria. Among the POPs that were detected in >/=70% of the subjects, 
      PCB153 (beta = -1.61, 95% CI: -2.55, -0.67, P = 0.001) and PCB180 (beta = -1.47, 95% 
      CI: -2.53, -0.40, P = 0.007) exhibited significant associations with decreased 
      eGFR, especially in females. In male participants, hexachlorobenzene (HCB) was 
      associated with eGFR (beta = -0.79, 95% CI: -1.53, -0.04, P = 0.040). Sex-dependent 
      associations with eGFR were also shown in the PCA model. Moreover, the 
      sex-dependent associations of PCBs were similarly observed in the adult 
      populations of the US NHANES. However, POPs exposure was not associated with 
      uACR, regardless of association model or population. The observed associations of 
      PCBs are supported by several experimental studies reported elsewhere. To our 
      knowledge, it is the first report that suggests significant associations of PCBs 
      and HCB with eGFR among general population, and further validations in other 
      populations are warranted.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Lee, Jeonghwan
AU  - Lee J
AD  - Department of Internal Medicine, Seoul National University Boramae Medical 
      Center, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National 
      University College of Medicine, Seoul, Republic of Korea.
FAU - Lee, Inae
AU  - Lee I
AD  - Graduate School of Public Health, Seoul National University, Seoul, Republic of 
      Korea; Institute of Health and Environment, Seoul National University, Seoul, 
      Republic of Korea.
FAU - Park, Jae Yoon
AU  - Park JY
AD  - Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk 
      University College of Medicine, Goyang, Gyeongju, Republic of Korea.
FAU - Kim, Sunmi
AU  - Kim S
AD  - Graduate School of Public Health, Seoul National University, Seoul, Republic of 
      Korea; Chemical Safety Research Center, Korea Research Institute of Chemical 
      Technology, Daejeon, South Korea.
FAU - Park, Hyunwoong
AU  - Park H
AD  - Department of Laboratory Medicine, Seoul National University Boramae Medical 
      Center, Seoul, Republic of Korea.
FAU - Jung, Sun Kyoung
AU  - Jung SK
AD  - Environmental Health Research Division, National Institute of Environmental 
      Research, Ministry of Environment, Incheon, 22689, Republic of Korea.
FAU - Lee, Chulwoo
AU  - Lee C
AD  - Environmental Health Research Division, National Institute of Environmental 
      Research, Ministry of Environment, Incheon, 22689, Republic of Korea.
FAU - Lee, Jung Pyo
AU  - Lee JP
AD  - Department of Internal Medicine, Seoul National University Boramae Medical 
      Center, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National 
      University College of Medicine, Seoul, Republic of Korea; Seoul National 
      University Kidney Research Institute, Seoul, 03080, Republic of Korea. Electronic 
      address: nephrolee@gmail.com.
FAU - Choi, Kyungho
AU  - Choi K
AD  - Graduate School of Public Health, Seoul National University, Seoul, Republic of 
      Korea; Institute of Health and Environment, Seoul National University, Seoul, 
      08826, Republic of Korea. Electronic address: kyungho@snu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20220518
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Environmental Health
MH  - *Environmental Pollutants
MH  - Female
MH  - Hexachlorobenzene
MH  - Humans
MH  - *Hydrocarbons, Chlorinated
MH  - Male
MH  - Nutrition Surveys
MH  - *Pesticides
MH  - *Polychlorinated Biphenyls
MH  - *Renal Insufficiency, Chronic/epidemiology
OTO - NOTNLM
OT  - Albuminuria
OT  - Chronic kidney disease
OT  - Glomerular filtration rate
OT  - PCB153
OT  - PCB180
OT  - Persistent organic pollutants
EDAT- 2022/05/22 06:00
MHDA- 2022/06/29 06:00
CRDT- 2022/05/21 19:26
PHST- 2021/12/27 00:00 [received]
PHST- 2022/05/08 00:00 [revised]
PHST- 2022/05/14 00:00 [accepted]
PHST- 2022/05/22 06:00 [pubmed]
PHST- 2022/06/29 06:00 [medline]
PHST- 2022/05/21 19:26 [entrez]
AID - S0045-6535(22)01491-6 [pii]
AID - 10.1016/j.chemosphere.2022.134998 [doi]
PST - ppublish
SO  - Chemosphere. 2022 Sep;303(Pt 1):134998. doi: 10.1016/j.chemosphere.2022.134998. 
      Epub 2022 May 18.