PMID- 35597919
OWN - NLM
STAT- MEDLINE
DCOM- 20220524
LR  - 20221207
IS  - 1471-2318 (Electronic)
IS  - 1471-2318 (Linking)
VI  - 22
IP  - 1
DP  - 2022 May 21
TI  - Longitudinal study on the progression of muscle status among community-dwelling 
      ambulatory older multiethnic Asians with type 2 diabetes mellitus.
PG  - 446
LID - 10.1186/s12877-022-03098-0 [doi]
LID - 446
AB  - BACKGROUND: Muscle health decline with age, but its deterioration in older 
      persons with type-2 diabetes mellitus (T2DM) over time is not well-established. 
      This study aimed to determine the change in muscle mass, handgrip strength and 
      gait speed over time among community-dwelling ambulatory older multi-ethnic Asian 
      patients with T2DM and their associated factors. METHODS: Among 387 eligible 
      patients aged 60-89 years who were recruited at baseline, 348 (89.9%) were 
      reviewed at a public primary care clinic in Singapore in the subsequent 9 to 
      34 months. The change in their clinical and functional status, levels of physical 
      activity and muscle status (mass, grip strength and gait speed based on the Asian 
      Working Group for Sarcopenia criteria) were recorded and compared. Their physical 
      activity levels were assessed using the Physical Activity Scale for the Elderly 
      (PASE) and International Physical Activity Questionnaire (IPAQ). Their quality of 
      life was evaluated based on the World Health Organization Quality of Life 
      (WHOQOL) domains. Linear regression analysis was used to identify the factors 
      associated with muscle health change. RESULTS: The study population comprised men 
      (52.9%), Chinese (69.3%), mean age of 68.4 +/- SD5.6 years and had at least 
      secondary education (76.4%). Their mean muscle mass significantly decreased by 
      0.03 +/- SD0.06 kg/m(2)/month, mean handgrip strength by 0.06 +/- SD0.26 kg/month and 
      negligible change in gait speed of 0.002 +/- SD0.01 m/sec/month. Their mean weight 
      significantly decreased by 0.5 +/- SD3.9 kg, waist and hip circumferences by 
      2.5 +/- SD6cm and 3.2 +/- SD5.1 cm respectively, with no change in BMI. Linear 
      regression shows significant associations between muscle mass change and 
      education level (beta = 0.36,p = 0.012, 95% CI = 0.08-0.64), BMI 
      (beta = 0.11,p = < 0.001, 95% CI = 0.05-0.17), change in medication class 
      (beta = 0.39,p = < 0.001, 95% CI = 0.06-0.71) and review interval (beta = - 0.003, 
      p < 0.001, 95% CI = -0.004--0.002). Gait speed change was associated with 
      singlehood (beta = - 0.13,p = 0.029, 95% CI = -0.25--0.01) and WHOQOL physical 
      health (beta = 0.01,p = 0.024, 95% CI = 0.00-0.02) domain. No factor was associated 
      with handgrip strength change. CONCLUSIONS: The study population with T2DM showed 
      significant decline in their mean weight, waist and hip circumferences, mean 
      muscle mass and mean grip strength but gait speed was unaffected. Muscle mass 
      change was associated with education level, BMI and length of review interval. 
      Handgrip strength change was not significantly correlated with any factor. Gait 
      speed change was associated with singlehood and physical health.
CI  - (c) 2022. The Author(s).
FAU - Tan, Ngiap Chuan
AU  - Tan NC
AD  - SingHealth Polyclinics, 167 Jalan Bukit Merah Connection One Tower 5 #15-10, 
      Singapore, 150167, Singapore. tan.ngiap.chuan@singhealth.com.sg.
AD  - Duke NUS Medical School, 8 College Road, Singapore, 169857, Singapore. 
      tan.ngiap.chuan@singhealth.com.sg.
FAU - Sankari, Usha
AU  - Sankari U
AD  - SingHealth Polyclinics, 167 Jalan Bukit Merah Connection One Tower 5 #15-10, 
      Singapore, 150167, Singapore.
FAU - Ng, Chiat Eng
AU  - Ng CE
AD  - SingHealth Polyclinics, 167 Jalan Bukit Merah Connection One Tower 5 #15-10, 
      Singapore, 150167, Singapore.
FAU - Koh, Yi Ling Eileen
AU  - Koh YLE
AD  - SingHealth Polyclinics, 167 Jalan Bukit Merah Connection One Tower 5 #15-10, 
      Singapore, 150167, Singapore.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220521
PL  - England
TA  - BMC Geriatr
JT  - BMC geriatrics
JID - 100968548
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People
MH  - *Diabetes Mellitus, Type 2/diagnosis
MH  - Hand Strength/physiology
MH  - Humans
MH  - Independent Living
MH  - Longitudinal Studies
MH  - Male
MH  - Muscle Strength
MH  - Muscles
MH  - Quality of Life
MH  - *Sarcopenia/epidemiology
MH  - Walking Speed
PMC - PMC9122804
OTO - NOTNLM
OT  - Asians
OT  - Gait speed
OT  - Handgrip strength
OT  - Muscle mass
OT  - Type-2 diabetes mellitus
COIS- The authors declare that they have no competing interests.
EDAT- 2022/05/22 06:00
MHDA- 2022/05/25 06:00
PMCR- 2022/05/21
CRDT- 2022/05/21 23:34
PHST- 2021/09/13 00:00 [received]
PHST- 2022/04/19 00:00 [accepted]
PHST- 2022/05/21 23:34 [entrez]
PHST- 2022/05/22 06:00 [pubmed]
PHST- 2022/05/25 06:00 [medline]
PHST- 2022/05/21 00:00 [pmc-release]
AID - 10.1186/s12877-022-03098-0 [pii]
AID - 3098 [pii]
AID - 10.1186/s12877-022-03098-0 [doi]
PST - epublish
SO  - BMC Geriatr. 2022 May 21;22(1):446. doi: 10.1186/s12877-022-03098-0.