PMID- 35598629
OWN - NLM
STAT- MEDLINE
DCOM- 20220926
LR  - 20231002
IS  - 1528-0012 (Electronic)
IS  - 0016-5085 (Print)
IS  - 0016-5085 (Linking)
VI  - 163
IP  - 4
DP  - 2022 Oct
TI  - Natural History of Alcohol-Associated Liver Disease: Understanding the Changing 
      Landscape of Pathophysiology and Patient Care.
PG  - 840-851
LID - S0016-5085(22)00522-4 [pii]
LID - 10.1053/j.gastro.2022.05.031 [doi]
AB  - Alcohol use and consequent liver disease are major burdens that have worsened 
      during the COVID-19 pandemic. There are several facets to the pathophysiology and 
      clinical consequences of alcohol-use disorder (AUD) and progression to 
      alcohol-associated liver disease (ALD) that require a concerted effort by 
      clinicians and translational and basic science investigators. Several recent 
      advances from bedside to bench and bench to bedside have been made in ALD. We 
      focused this review on a case-based approach that provides a human context to 
      these important advances across the spectrum of ALD.
CI  - Copyright (c) 2022 AGA Institute. Published by Elsevier Inc. All rights reserved.
FAU - Bajaj, Jasmohan S
AU  - Bajaj JS
AD  - Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth 
      University, Richmond, Virginia; Central Virginia Veterans Healthcare System, 
      Richmond, Virginia. Electronic address: jasmohan.bajaj@vcuhealth.org.
FAU - Nagy, Laura E
AU  - Nagy LE
AD  - Center for Liver Disease Research, Departments of Inflammation and Immunity and 
      Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio; Department of 
      Molecular Medicine, Case Western Reserve University, Cleveland, Ohio.
LA  - eng
GR  - U01 AA026264/AA/NIAAA NIH HHS/United States
GR  - R21 TR003095/TR/NCATS NIH HHS/United States
GR  - U01 AA026938/AA/NIAAA NIH HHS/United States
GR  - I01 CX001076/CX/CSRD VA/United States
GR  - P50 AA024333/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20220519
PL  - United States
TA  - Gastroenterology
JT  - Gastroenterology
JID - 0374630
SB  - IM
MH  - *Alcoholism/complications/epidemiology
MH  - *COVID-19
MH  - Humans
MH  - *Liver Diseases, Alcoholic/epidemiology/etiology/therapy
MH  - Pandemics
MH  - Patient Care
PMC - PMC9509416
MID - NIHMS1809300
COIS- Conflict of interest: None for any author
EDAT- 2022/05/23 06:00
MHDA- 2022/09/28 06:00
PMCR- 2023/10/01
CRDT- 2022/05/22 19:22
PHST- 2022/01/24 00:00 [received]
PHST- 2022/05/12 00:00 [revised]
PHST- 2022/05/14 00:00 [accepted]
PHST- 2022/05/23 06:00 [pubmed]
PHST- 2022/09/28 06:00 [medline]
PHST- 2022/05/22 19:22 [entrez]
PHST- 2023/10/01 00:00 [pmc-release]
AID - S0016-5085(22)00522-4 [pii]
AID - 10.1053/j.gastro.2022.05.031 [doi]
PST - ppublish
SO  - Gastroenterology. 2022 Oct;163(4):840-851. doi: 10.1053/j.gastro.2022.05.031. 
      Epub 2022 May 19.