PMID- 35598818 OWN - NLM STAT- MEDLINE DCOM- 20220623 LR - 20220623 IS - 1873-6424 (Electronic) IS - 0269-7491 (Linking) VI - 307 DP - 2022 Aug 15 TI - The association of co-exposure to polycyclic aromatic hydrocarbon and phthalates with blood cell-based inflammatory biomarkers in children: A panel study. PG - 119479 LID - S0269-7491(22)00693-5 [pii] LID - 10.1016/j.envpol.2022.119479 [doi] AB - The association of co-exposure to polycyclic aromatic hydrocarbons (PAHs) and phthalates (PAEs) with blood cell-based inflammatory biomarkers is largely unknown. We conducted a panel study of 144 children aged 4-12 years, with up to 3 repeated visits across 3 seasons. For each visit, we collected the first-morning urine for 4 consecutive days and fasting blood on the day of physical examination. We developed a gas chromatography/tandem mass spectrometry method to detect the metabolites of 10 PAHs (OH-PAHs) and 10 PAEs (mPAEs) in urine samples. We employed linear mixed-effects models to evaluate the individual associations of each OH-PAH and mPAE with blood cell-based inflammatory biomarkers over different lag times. Bayesian kernel machine regression (BKMR) and quantile g-computation were used to evaluate the overall associations of OH-PAHs and mPAEs mixtures with blood cell-based inflammatory biomarkers. After multiple adjustments, we found positive associations of summed hydroxylphenanthrene ( summation operatorOHPHE), summed OH-PAHs, and mono-n-butyl phthalate with inflammatory biomarkers such as neutrophil count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and the systemic immune-inflammation index (SII) at lag 0 (the day of physical examination). Each 1% increase in summation operatorOHPHE was related to a 0.18% (95% confidence interval: 0.10%, 0.25%) increase in SII, which was the strongest among the above associations. The results of BKMR and quantile g-computation suggested that co-exposure to PAHs and PAEs mixture was associated with an elevated white blood cell count, neutrophil count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and SII, to which summation operatorOHPHE and 1-hydroxypyrene (1-OHPYR) might be the major contributors. In addition, gender and age modified the associations of summation operatorOHPHE and 1-OHPYR with inflammatory biomarkers, where girls and younger children were more susceptible. In conclusion, co-exposure to PAHs and PAEs was associated with elevated inflammation in children, in which summation operatorOHPHE and 1-OHPYR might play important roles. CI - Copyright (c) 2022 Elsevier Ltd. All rights reserved. FAU - Zhao, Lei AU - Zhao L AD - Department of Occupational and Environmental Health, Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Public Health, Medical College of Qinghai University, Xining, Qinghai, China. FAU - Liu, Miao AU - Liu M AD - Department of Occupational and Environmental Health, Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Liu, Linlin AU - Liu L AD - Department of Occupational and Environmental Health, Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Guo, Wenting AU - Guo W AD - Department of Occupational and Environmental Health, Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Yang, Huihua AU - Yang H AD - Department of Occupational and Environmental Health, Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Chen, Shuang AU - Chen S AD - Department of Occupational and Environmental Health, Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Yu, Jie AU - Yu J AD - Department of Occupational and Environmental Health, Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Li, Meng AU - Li M AD - Department of Occupational and Environmental Health, Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Fang, Qin AU - Fang Q AD - Department of Medical Affairs, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, Guangdong, China. FAU - Lai, Xuefeng AU - Lai X AD - Department of Occupational and Environmental Health, Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Yang, Liangle AU - Yang L AD - Department of Occupational and Environmental Health, Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Zhang, Xiaomin AU - Zhang X AD - Department of Occupational and Environmental Health, Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: mingxz117@163.com. LA - eng PT - Journal Article DEP - 20220519 PL - England TA - Environ Pollut JT - Environmental pollution (Barking, Essex : 1987) JID - 8804476 RN - 0 (Biomarkers) RN - 0 (Polycyclic Aromatic Hydrocarbons) SB - IM MH - Bayes Theorem MH - Biomarkers MH - Blood Platelets MH - Child MH - Female MH - Gas Chromatography-Mass Spectrometry MH - Humans MH - Inflammation/chemically induced MH - *Polycyclic Aromatic Hydrocarbons/analysis OTO - NOTNLM OT - Bayesian kernel machine regression OT - Blood cell-based inflammatory biomarkers OT - Phthalates OT - Polycyclic aromatic hydrocarbons OT - Quantile g-computation EDAT- 2022/05/23 06:00 MHDA- 2022/06/24 06:00 CRDT- 2022/05/22 19:33 PHST- 2021/10/09 00:00 [received] PHST- 2022/05/11 00:00 [revised] PHST- 2022/05/12 00:00 [accepted] PHST- 2022/05/23 06:00 [pubmed] PHST- 2022/06/24 06:00 [medline] PHST- 2022/05/22 19:33 [entrez] AID - S0269-7491(22)00693-5 [pii] AID - 10.1016/j.envpol.2022.119479 [doi] PST - ppublish SO - Environ Pollut. 2022 Aug 15;307:119479. doi: 10.1016/j.envpol.2022.119479. Epub 2022 May 19.