PMID- 35599165
OWN - NLM
STAT- MEDLINE
DCOM- 20220608
LR  - 20220920
IS  - 1873-3344 (Electronic)
IS  - 0162-0134 (Linking)
VI  - 233
DP  - 2022 Aug
TI  - Complexes of copper(II) with tetradentate S,O-ligands: Synthesis, 
      characterization, DNA/albumin interactions, molecular docking simulations and 
      antitumor activity.
PG  - 111861
LID - S0162-0134(22)00150-7 [pii]
LID - 10.1016/j.jinorgbio.2022.111861 [doi]
AB  - Four new complexes of copper(II) with S,O-tetradentate ligands, derivatives of 
      thiosalicylic acid, encompassing an ethylene-, propylene-, butylene- and 
      pentylene- bridge, were synthesized and characterized by microanalysis, molecular 
      conductance and infrared (IR) spectra. The structures were assumed based on the 
      previously mentioned analyses and confirmed with the results of electron 
      paramagnetic resonance (EPR) spectra. The reactivity of complexes towards 
      L-methionine (L-Met), L-cysteine (L-Cys) and guanosine-5'-monophosphate (5'-GMP) 
      was also examined. Complex C1 ([Cu(S,O-ethylene-thiosalicylic acid)(H(2)O)(2)]) 
      containing two inert methylene groups in the side chain of ligand shows the 
      highest reactivity, while the least reactive is complex C4 
      ([Cu(S,O-pentylene-thiosalicylic acid)(H(2)O)(2)]) with five methylene groups. 
      All complexes showed the highest reactivity towards L-Met and the lowest 
      reactivity towards 5'-GMP. The interactions of complexes C1-C4 with calf thymus 
      DNA (ct-DNA) were examined by ultraviolet-visible (UV-Vis) absorption and 
      fluorescence spectral studies, revealing good DNA interaction abilities. All 
      synthesized complexes C1-C4 show to interact with human serum albumin (HSA) with 
      high values of binding constants. Complexes interaction with DNA/HSA was also 
      confirmed using molecular docking simulations. All synthesized complexes reduce 
      viability of human colon, breast and lung cancer cells, evaluated by MTT 
      (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) colorimetric 
      technique. The complex [Cu(S,O-pentylene- thiosalicylic acid)(H(2)O)(2)] showed 
      the highest binding affinity constants to DNA/HSA and highest cytotoxicity, thus 
      presenting a good candidate for further pharmacological research in the field of 
      colon, breast and lung cancer therapy.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Zivanovic, Ana S
AU  - Zivanovic AS
AD  - Department of Phamacy, Faculty of Medical Sciences, University of Kragujevac, 
      Svetozara Markovica 69, 34000 Kragujevac, Serbia.
FAU - Bukonjic, Andriana M
AU  - Bukonjic AM
AD  - Department of Phamacy, Faculty of Medical Sciences, University of Kragujevac, 
      Svetozara Markovica 69, 34000 Kragujevac, Serbia. Electronic address: 
      andriana.bukonjic@medf.kg.ac.rs.
FAU - Jovanovic-Stevic, Snezana
AU  - Jovanovic-Stevic S
AD  - University of Kragujevac, Institute for Information Technologies, Department of 
      Science, Jovana Cvijica bb, 34000 Kragujevac, Serbia.
FAU - Bogojeski, Jovana
AU  - Bogojeski J
AD  - University of Kragujevac, Faculty of Science, R. Domanovica 12, P. O. Box 60, 
      34000 Kragujevac, Serbia.
FAU - Cocic, Dusan
AU  - Cocic D
AD  - University of Kragujevac, Faculty of Science, R. Domanovica 12, P. O. Box 60, 
      34000 Kragujevac, Serbia.
FAU - Bijelic, Ana Popovic
AU  - Bijelic AP
AD  - University of Belgrade - Faculty of Physical Chemistry, Studentski trg 12-16, 
      11158 Belgrade, Serbia.
FAU - Ratkovic, Zoran R
AU  - Ratkovic ZR
AD  - University of Kragujevac, Faculty of Science, R. Domanovica 12, P. O. Box 60, 
      34000 Kragujevac, Serbia.
FAU - Volarevic, Vladislav
AU  - Volarevic V
AD  - Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, 
      Svetozara Markovica 69, 34000 Kragujevac, Serbia; Department of Microbiology and 
      Immunology, Faculty of Medical Sciences, University of Kragujevac, Svetozara 
      Markovica 69, 34000 Kragujevac, Serbia.
FAU - Miloradovic, Dragana
AU  - Miloradovic D
AD  - Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, 
      Svetozara Markovica 69, 34000 Kragujevac, Serbia.
FAU - Tomovic, Dusan Lj
AU  - Tomovic DL
AD  - Department of Phamacy, Faculty of Medical Sciences, University of Kragujevac, 
      Svetozara Markovica 69, 34000 Kragujevac, Serbia.
FAU - Radic, Gordana P
AU  - Radic GP
AD  - Department of Phamacy, Faculty of Medical Sciences, University of Kragujevac, 
      Svetozara Markovica 69, 34000 Kragujevac, Serbia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220513
PL  - United States
TA  - J Inorg Biochem
JT  - Journal of inorganic biochemistry
JID - 7905788
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Coordination Complexes)
RN  - 0 (Ethylenes)
RN  - 0 (Ligands)
RN  - 789U1901C5 (Copper)
RN  - 85-32-5 (Guanosine Monophosphate)
RN  - 9007-49-2 (DNA)
RN  - ZIF514RVZR (Serum Albumin, Human)
SB  - IM
MH  - *Antineoplastic Agents/chemistry/metabolism/pharmacology
MH  - *Coordination Complexes/chemistry/metabolism
MH  - Copper/chemistry/metabolism
MH  - DNA/chemistry/metabolism
MH  - Ethylenes/metabolism
MH  - Guanosine Monophosphate/metabolism
MH  - Humans
MH  - Ligands
MH  - Lung Neoplasms/drug therapy/metabolism
MH  - Molecular Docking Simulation
MH  - Neoplasms/drug therapy/metabolism
MH  - Serum Albumin, Human/chemistry
OTO - NOTNLM
OT  - Biological activity
OT  - Copper(II)-complexes
OT  - Docking
OT  - Interactions
OT  - S,O-ligands
EDAT- 2022/05/23 06:00
MHDA- 2022/06/09 06:00
CRDT- 2022/05/22 22:12
PHST- 2021/12/27 00:00 [received]
PHST- 2022/05/02 00:00 [revised]
PHST- 2022/05/08 00:00 [accepted]
PHST- 2022/05/23 06:00 [pubmed]
PHST- 2022/06/09 06:00 [medline]
PHST- 2022/05/22 22:12 [entrez]
AID - S0162-0134(22)00150-7 [pii]
AID - 10.1016/j.jinorgbio.2022.111861 [doi]
PST - ppublish
SO  - J Inorg Biochem. 2022 Aug;233:111861. doi: 10.1016/j.jinorgbio.2022.111861. Epub 
      2022 May 13.