PMID- 35599218 OWN - NLM STAT- MEDLINE DCOM- 20220823 LR - 20220904 IS - 1878-0539 (Electronic) IS - 1748-6815 (Linking) VI - 75 IP - 8 DP - 2022 Aug TI - Outcomes associated with proton pump inhibitors and distal radius fractures: A post-hoc comparative analysis. PG - 2650-2657 LID - S1748-6815(22)00197-8 [pii] LID - 10.1016/j.bjps.2022.04.013 [doi] AB - Long-term, high-dose, daily proton pump inhibitors (PPI) may impact outcomes associated with distal radius fractures (DRF). The hypothesis was that differences existed in patient demographics, but there existed no differences in injury patterns, interventions, post-operative complications, and patient-reported outcomes between patients not on a PPI and patients on a PPI with a DRF. METHODS: An IRB-approved, post-hoc analysis of patients with DRF from 2012 through 2018 was performed. Patients included were age >/=18 years, sustained a DRF, had completed medical and medication records, Quick Disabilities of the Arm, Shoulder and Hand (DASH) scores, Global Assessment of Functioning (GAF) scores, visual analogue scale (VAS) pain scores, and a minimum of 1-year follow-up. Patients were stratified into two cohorts. Cohort one patients had no prescription or over-the-counter PPI use (no PPI cohort). Cohort two patients had adherence to a long-term, high-dose, daily PPI (PPI cohort). RESULTS: Two hundred and eighty-one DRF patients were included. Of these 281 patients, 240 were in the no PPI cohort and 41 were in the PPI cohort. Patients in the PPI cohort had more median nerve injuries (12% versus 3%, p = 0.025) and radial shaft fractures (5% versus 0%, p = 0.020), less contralateral upper extremity injuries (0% versus 4%, p = 0.001), and more post-operative nonunions (7% versus 1%, p = 0.029) compared to patients in the no PPI cohort. CONCLUSIONS: Long-term, high-dose, daily PPI's may be associated with more median nerve injuries and radial shaft fractures, less contralateral upper extremity injuries, and more post-operative nonunions compared to DRF patients not on a PPI. CI - Copyright (c) 2022 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Klifto, Kevin M AU - Klifto KM AD - Division of Plastic and Reconstructive Surgery, University of Missouri School of Medicine, Columbia, MO, United States; Department of Orthopaedic Surgery, Division of Hand Surgery, Duke University School of Medicine, 2301 Erwin Rd, Durham, NC 27710, United States. Electronic address: kklifto@gmail.com. FAU - Ruch, David S AU - Ruch DS AD - Department of Orthopaedic Surgery, Division of Hand Surgery, Duke University School of Medicine, 2301 Erwin Rd, Durham, NC 27710, United States. Electronic address: d.ruch@duke.edu. FAU - Mithani, Suhail K AU - Mithani SK AD - Department of Orthopaedic Surgery, Division of Hand Surgery, Duke University School of Medicine, 2301 Erwin Rd, Durham, NC 27710, United States. Electronic address: suhail.mithani@duke.edu. FAU - Pidgeon, Tyler S AU - Pidgeon TS AD - Department of Orthopaedic Surgery, Division of Hand Surgery, Duke University School of Medicine, 2301 Erwin Rd, Durham, NC 27710, United States. Electronic address: tyler.pidgeon@duke.edu. FAU - Richard, Marc J AU - Richard MJ AD - Department of Orthopaedic Surgery, Division of Hand Surgery, Duke University School of Medicine, 2301 Erwin Rd, Durham, NC 27710, United States. Electronic address: marc.richard@duke.edu. FAU - Klifto, Christopher S AU - Klifto CS AD - Department of Orthopaedic Surgery, Division of Hand Surgery, Duke University School of Medicine, 2301 Erwin Rd, Durham, NC 27710, United States. Electronic address: christopher.klifto@duke.edu. LA - eng PT - Journal Article DEP - 20220422 PL - Netherlands TA - J Plast Reconstr Aesthet Surg JT - Journal of plastic, reconstructive & aesthetic surgery : JPRAS JID - 101264239 RN - 0 (Proton Pump Inhibitors) SB - IM MH - Adolescent MH - Cohort Studies MH - Humans MH - Patient Reported Outcome Measures MH - Proton Pump Inhibitors/adverse effects MH - *Radius Fractures/surgery MH - Shoulder OTO - NOTNLM OT - Patient reported outcome measures OT - Proton pump inhibitors OT - Radius fractures EDAT- 2022/05/23 06:00 MHDA- 2022/08/24 06:00 CRDT- 2022/05/22 22:14 PHST- 2021/06/19 00:00 [received] PHST- 2022/03/09 00:00 [revised] PHST- 2022/04/12 00:00 [accepted] PHST- 2022/05/23 06:00 [pubmed] PHST- 2022/08/24 06:00 [medline] PHST- 2022/05/22 22:14 [entrez] AID - S1748-6815(22)00197-8 [pii] AID - 10.1016/j.bjps.2022.04.013 [doi] PST - ppublish SO - J Plast Reconstr Aesthet Surg. 2022 Aug;75(8):2650-2657. doi: 10.1016/j.bjps.2022.04.013. Epub 2022 Apr 22.