PMID- 35599359
OWN - NLM
STAT- MEDLINE
DCOM- 20221115
LR  - 20221115
IS  - 1365-4632 (Electronic)
IS  - 0011-9059 (Linking)
VI  - 61
IP  - 12
DP  - 2022 Dec
TI  - Cutaneous manifestations of antineutrophil cytoplasmic antibody-associated 
      vasculitis (AAV): a concise review with emphasis on clinical and histopathologic 
      correlation.
PG  - 1442-1451
LID - 10.1111/ijd.16247 [doi]
AB  - Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) comprises 
      a group of small vessel vasculitides grouped by commonalities of clinical 
      manifestations and ANCA testing. Skin findings are not uncommon, although there 
      is considerable overlap and many times nonspecificity. In general, patients with 
      skin findings tend to have more significant systemic illness, and skin lesions 
      most often develop simultaneously or following onset of systemic symptoms. There 
      are clinical and pathological clues of help in the differentiation of skin 
      findings in these disorders. Purpura of various forms with leukocytoclastic 
      vasculitis is common to all AAV. Granulomatosis with polyangiitis (GPA) comprises 
      the largest number of patients with an AAV. Upper airway, oral, ear, and facial 
      lesions, with or without granuloma, are more commonly seen in this AAV. Pyoderma 
      gangrenosum-like lesions, including facial location, while not common are most 
      closely associated with GPA. Eosinophilic granulomatosis with polyangiitis (EGPA) 
      as its name implies is more closely associated with eosinophilic, allergic, or 
      asthmatic conditions. Papular lesions of the extensor extremities showing 
      extravascular granulomatous changes are characteristic but not specific for EGPA. 
      Microscopic polyangiitis (MPA) is more closely associated with livedoid skin 
      changes, and vascular inflammation tends to be deeper in the skin than with the 
      other AAV. Extravascular granulomas are not expected. While the skin findings in 
      AAV can be nonspecific and overlapping, combining careful full skin examination 
      with histopathologic study of selected lesions is critical to making the correct 
      diagnosis and in ruling out other similar diseases not ANCA related. The aim of 
      this article is to encourage increased participation by dermatologists and 
      dermatopathologists in the care of these patients.
CI  - (c) 2022 the International Society of Dermatology.
FAU - Gibson, Lawrence E
AU  - Gibson LE
AD  - Departments of Dermatology and Laboratory Medicine and Pathology, Mayo Clinic, 
      Rochester, MN, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220522
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - Humans
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - *Granulomatosis with Polyangiitis/complications/diagnosis
MH  - *Churg-Strauss Syndrome/complications/diagnosis
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/complications/diagnosis
MH  - Granuloma
MH  - *Skin Diseases/etiology/complications
OTO - NOTNLM
OT  - ANCA-associated vasculitis (AAV)
OT  - cutaneous vasculitis
OT  - eosinophilic granulomatosis with polyangiitis (EGPA)
OT  - granulomatosis with polyangiitis (GPA)
OT  - microscopic polyangiitis (MPA)
OT  - pyoderma gangrenosum (PG)
EDAT- 2022/05/24 06:00
MHDA- 2022/11/16 06:00
CRDT- 2022/05/23 01:03
PHST- 2022/04/01 00:00 [revised]
PHST- 2022/02/22 00:00 [received]
PHST- 2022/04/21 00:00 [accepted]
PHST- 2022/05/24 06:00 [pubmed]
PHST- 2022/11/16 06:00 [medline]
PHST- 2022/05/23 01:03 [entrez]
AID - 10.1111/ijd.16247 [doi]
PST - ppublish
SO  - Int J Dermatol. 2022 Dec;61(12):1442-1451. doi: 10.1111/ijd.16247. Epub 2022 May 
      22.