PMID- 35600044
OWN - NLM
STAT- MEDLINE
DCOM- 20220524
LR  - 20220716
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2022
DP  - 2022
TI  - hsa-miR-9-5p-Mediated TSPAN9 Downregulation Is Positively Related to Both Poor 
      Hepatocellular Carcinoma Prognosis and the Tumor Immune Infiltration.
PG  - 9051229
LID - 10.1155/2022/9051229 [doi]
LID - 9051229
AB  - Tetraspanins (TSPANs) play crucial roles in cell adhesion, migration, and 
      metastasis of human cancer. However, there is no study in revealing the aspects 
      of TSPAN9 traits and its functions in hepatocellular carcinoma (HCC) prognosis. 
      Our study is the first to portray the TSPAN9 expression in HCC tissues with 
      immunohistochemistry (IHC) analysis. Subsequently, a series of bioinformatics 
      analyses such as expression estimation, survival assessment, and correlation 
      analysis were implemented to dig out the possible upstream noncoding RNAs 
      (ncRNAs) for TSPAN9 in HCC. In this way, the relevance within TSPAN9 and tumor 
      immunity was then explored. We found that the TSPAN9 was downregulated in HCC 
      tissues and had a correlation with HCC prognosis. Furthermore, we identified that 
      the AL139383.1-hsa-miR-9-5p axis was the upstream ncRNA-related pathway most 
      associated with TSPAN9 in HCC. Besides that, expression of TSPAN9 held a 
      significantly negative correlation with tumor immunocyte infiltration as well as 
      immune checkpoint CTLA4. TSPAN9-related immunomodulators were mainly enriched in 
      T cell activation, leukocyte cell-cell adhesion, regulation of T cell activation, 
      and regulation of leukocyte cell-cell adhesion signaling pathway. In conclusion, 
      our results indicated that hsa-miR-9-5p-mediated downregulation of TSPAN9 was 
      associated with poor HCC prognosis, immune-related signaling pathway, and tumor 
      immune infiltration.
CI  - Copyright (c) 2022 Shengkui Tan et al.
FAU - Tan, Shengkui
AU  - Tan S
AD  - Department of Epidemiology and Health Statistics, Xiangya School of Public 
      Health, Central South University, Changsha, 410078 Hunan, China.
AD  - Department of Epidemiology and Health Statistics, Guilin Medical University, 
      Guilin, 541004 Guangxi, China.
FAU - Song, Xin
AU  - Song X
AD  - Department of Epidemiology and Health Statistics, Guilin Medical University, 
      Guilin, 541004 Guangxi, China.
FAU - Zhang, Chenchen
AU  - Zhang C
AD  - Department of Epidemiology and Health Statistics, Guilin Medical University, 
      Guilin, 541004 Guangxi, China.
FAU - Sun, Yishu
AU  - Sun Y
AD  - Department of Epidemiology and Health Statistics, Guilin Medical University, 
      Guilin, 541004 Guangxi, China.
FAU - Zhang, Jiaxi
AU  - Zhang J
AD  - Department of Epidemiology and Health Statistics, Guilin Medical University, 
      Guilin, 541004 Guangxi, China.
FAU - Zhang, Zhongqi
AU  - Zhang Z
AD  - Department of Epidemiology and Health Statistics, Guilin Medical University, 
      Guilin, 541004 Guangxi, China.
FAU - Zhang, Rongcheng
AU  - Zhang R
AD  - Department of Epidemiology and Health Statistics, Guilin Medical University, 
      Guilin, 541004 Guangxi, China.
FAU - Zhang, Tianmiao
AU  - Zhang T
AD  - Department of Epidemiology and Health Statistics, Guilin Medical University, 
      Guilin, 541004 Guangxi, China.
FAU - Zhu, Xiaonian
AU  - Zhu X
AUID- ORCID: 0000-0002-6175-3204
AD  - Department of Epidemiology and Health Statistics, Guilin Medical University, 
      Guilin, 541004 Guangxi, China.
FAU - Tan, Hongzhuan
AU  - Tan H
AUID- ORCID: 0000-0001-5330-5578
AD  - Department of Epidemiology and Health Statistics, Xiangya School of Public 
      Health, Central South University, Changsha, 410078 Hunan, China.
LA  - eng
PT  - Journal Article
DEP - 20220512
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (MIRN92 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (TSPAN9 protein, human)
RN  - 0 (Tetraspanins)
SB  - IM
MH  - *Carcinoma, Hepatocellular
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation
MH  - Down-Regulation
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - *Liver Neoplasms
MH  - *MicroRNAs/genetics/metabolism
MH  - Prognosis
MH  - Tetraspanins/genetics/metabolism
PMC - PMC9119760
COIS- There is no conflict of interest within the authors in this study.
EDAT- 2022/05/24 06:00
MHDA- 2022/05/25 06:00
PMCR- 2022/05/12
CRDT- 2022/05/23 03:47
PHST- 2022/03/04 00:00 [received]
PHST- 2022/04/16 00:00 [accepted]
PHST- 2022/05/23 03:47 [entrez]
PHST- 2022/05/24 06:00 [pubmed]
PHST- 2022/05/25 06:00 [medline]
PHST- 2022/05/12 00:00 [pmc-release]
AID - 10.1155/2022/9051229 [doi]
PST - epublish
SO  - J Immunol Res. 2022 May 12;2022:9051229. doi: 10.1155/2022/9051229. eCollection 
      2022.