PMID- 35601413
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220524
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 10
DP  - 2022
TI  - Pulmonary Valve Replacement in Repaired Tetralogy of Fallot: Midterm Impact on 
      Biventricular Response and Adverse Clinical Outcomes.
PG  - 864455
LID - 10.3389/fped.2022.864455 [doi]
LID - 864455
AB  - BACKGROUND: Pulmonary regurgitation (PR), though well tolerated for short term in 
      patients with repaired tetralogy of Fallot (rTOF), could lead to right 
      ventricular (RV) dysfunction, arrhythmias, and sudden cardiac death. Pulmonary 
      valve replacement (PVR), considered as the gold-standard treatment for PR, is 
      performed to mitigate these late effects. In this study, we aimed to evaluate the 
      midterm outcomes and predictors of adverse clinical outcomes (ACO). METHODS: From 
      May 2014 to December 2017, 42 patients with rTOF undergoing surgical or 
      transcatheter PVR in our department were retrospectively included. Cardiovascular 
      magnetic resonance was performed before PVR (pre-PVR), early after PVR (early 
      post-PVR), and midterm after PVR (midterm post-PVR). Medical history and 
      individual data were collected from medical records. ACO included all-cause 
      death, new-onset arrhythmia, prosthetic valve failure, and repeat PVR. RESULTS: 
      The median follow-up duration was 4.7 years. PVR was performed at a median age of 
      21.6 years. There was no early or late death. Freedom from ACO at 3 and 5 years 
      was 88.1 +/- 5% and 58.2 +/- 9%, respectively. RV end-diastolic volume index (RVEDVI) 
      and end-systolic volume index (RVESVI) significantly reduced early after PVR and 
      further decreased by midterm follow-up (pre-PVR vs. early post-PVR vs. midterm 
      post-PVR: RVEDVI, 155.2 +/- 34.7 vs. 103.8 +/- 31.2 vs. 95.1 +/- 28.6 ml/m(2), p < 
      0.001; RVESVI, 102.9 +/- 28.5 vs. 65.4 +/- 28.2 vs. 57.7 +/- 23.4 ml/m(2), p < 0.001). 
      Multivariable analysis revealed that the occurrence of ACO was significantly 
      increased in patients with lower left ventricular end-systolic volume index. 
      CONCLUSIONS: A significant reduction of RV volume occurred early after PVR, 
      followed by a further improvement of biventricular function by midterm follow-up. 
      The midterm freedom from ACO was favorable.
CI  - Copyright (c) 2022 He, Feng, Yuan, Ma, Yang, Lu, Zhang and Li.
FAU - He, Fengpu
AU  - He F
AD  - Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang 
      University College of Medicine, Hangzhou, China.
AD  - Paediatric Cardiac Surgery Centre, National Centre for Cardiovascular Diseases, 
      Peking Union Medical College, Fuwai Hospital, Chinese Academy of Medical 
      Sciences, Beijing, China.
FAU - Feng, Zicong
AU  - Feng Z
AD  - Paediatric Cardiac Surgery Centre, National Centre for Cardiovascular Diseases, 
      Peking Union Medical College, Fuwai Hospital, Chinese Academy of Medical 
      Sciences, Beijing, China.
FAU - Yuan, Jianhui
AU  - Yuan J
AD  - Paediatric Cardiac Surgery Centre, National Centre for Cardiovascular Diseases, 
      Peking Union Medical College, Fuwai Hospital, Chinese Academy of Medical 
      Sciences, Beijing, China.
FAU - Ma, Kai
AU  - Ma K
AD  - Paediatric Cardiac Surgery Centre, National Centre for Cardiovascular Diseases, 
      Peking Union Medical College, Fuwai Hospital, Chinese Academy of Medical 
      Sciences, Beijing, China.
FAU - Yang, Keming
AU  - Yang K
AD  - Paediatric Cardiac Surgery Centre, National Centre for Cardiovascular Diseases, 
      Peking Union Medical College, Fuwai Hospital, Chinese Academy of Medical 
      Sciences, Beijing, China.
FAU - Lu, Minjie
AU  - Lu M
AD  - Department of Magnetic Resonance Imaging, National Centre for Cardiovascular 
      Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, 
      Beijing, China.
FAU - Zhang, Sen
AU  - Zhang S
AD  - Paediatric Cardiac Surgery Centre, National Centre for Cardiovascular Diseases, 
      Peking Union Medical College, Fuwai Hospital, Chinese Academy of Medical 
      Sciences, Beijing, China.
FAU - Li, Shoujun
AU  - Li S
AD  - Paediatric Cardiac Surgery Centre, National Centre for Cardiovascular Diseases, 
      Peking Union Medical College, Fuwai Hospital, Chinese Academy of Medical 
      Sciences, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20220506
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC9120843
OTO - NOTNLM
OT  - cardiovascular magnetic resonance
OT  - pulmonary regurgitation
OT  - pulmonary valve replacement
OT  - repaired tetralogy of fallot
OT  - right ventricular reverse remodeling
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/05/24 06:00
MHDA- 2022/05/24 06:01
PMCR- 2022/05/06
CRDT- 2022/05/23 04:09
PHST- 2022/01/28 00:00 [received]
PHST- 2022/04/06 00:00 [accepted]
PHST- 2022/05/23 04:09 [entrez]
PHST- 2022/05/24 06:00 [pubmed]
PHST- 2022/05/24 06:01 [medline]
PHST- 2022/05/06 00:00 [pmc-release]
AID - 10.3389/fped.2022.864455 [doi]
PST - epublish
SO  - Front Pediatr. 2022 May 6;10:864455. doi: 10.3389/fped.2022.864455. eCollection 
      2022.