PMID- 35602530
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 0972-124X (Print)
IS  - 0975-1580 (Electronic)
IS  - 0972-124X (Linking)
VI  - 26
IP  - 3
DP  - 2022 May-Jun
TI  - Salivary tumor necrosis factor-alpha levels in periodontitis associated with 
      diabetes mellitus after low level laser therapy as an adjunct to scaling and root 
      planning: A randomized clinical trial.
PG  - 236-244
LID - 10.4103/jisp.jisp_150_21 [doi]
AB  - CONTEXT: Tumor necrosis factor-alpha (TNF-alpha) has been shown to play a critical 
      role in the pathogenesis of periodontitis and diabetes. Nonsurgical periodontal 
      therapy was shown to reduce inflammation and improves glycemic status. Recently, 
      adjunctive low level laser therapy (LLLT) has been shown to alter the 
      inflammatory process. AIM: To evaluate and compare the alteration in TNF-alpha levels 
      before and after treatment in patients with periodontitis with and without type 2 
      diabetes mellitus (T2DM). SETTINGS AND DESIGN: Randomised clinico-biochemical 
      study was carried out for 8 weeks from September 2019 to December 2020. MATERIALS 
      AND METHODS: Sixty-four participants were divided into Groups A (periodontitis) 
      and B (periodontitis associated with T2DM), based on probing depth >/=5 mm, 
      clinical attachment level >/=2 mm, and history of T2DM. Later were subdivided into 
      A1, A2, B1, B2, based on assigned treatments. Clinical periodontal parameters and 
      salivary TNF-alpha levels were evaluated and compared at baseline to 8 weeks. 
      STATISTICAL ANALYSIS: Multiple group comparisons were done using analysis of 
      variance, intra group comparisons were made using t-tests. RESULTS: Comparison of 
      periodontal parameters and salivary TNF-alpha levels from baseline to 8 weeks showed 
      statistically significant difference (P < 0.05) in all groups, indicating a 
      positive effect of scaling and root planing (SRP) and adjunctive LLLT. 
      CONCLUSION: Both SRP and SRP with adjunctive LLLT effectively altered TNF-alpha 
      levels, correlating reduced periodontal inflammation.
CI  - Copyright: (c) 2022 Indian Society of Periodontology.
FAU - Pulivarthi, Praneetha
AU  - Pulivarthi P
AD  - Department of Periodontology, Narayana Dental College and Hospital, Nellore, 
      Andhra Pradesh, India.
FAU - Chava, Vijay Kumar
AU  - Chava VK
AD  - Department of Periodontology, Narayana Dental College and Hospital, Nellore, 
      Andhra Pradesh, India.
FAU - Gunupati, Sumanth
AU  - Gunupati S
AD  - Department of Periodontology, Narayana Dental College and Hospital, Nellore, 
      Andhra Pradesh, India.
LA  - eng
PT  - Journal Article
DEP - 20220502
PL  - India
TA  - J Indian Soc Periodontol
JT  - Journal of Indian Society of Periodontology
JID - 101499342
PMC - PMC9118935
OTO - NOTNLM
OT  - Low-level laser therapy
OT  - periodontitis
OT  - salivary tumor necrosis factor-alpha
OT  - scaling and root planing
OT  - type 2 diabetes mellitus
COIS- There are no conflicts of interest.
EDAT- 2022/05/24 06:00
MHDA- 2022/05/24 06:01
PMCR- 2022/05/01
CRDT- 2022/05/23 04:27
PHST- 2021/03/25 00:00 [received]
PHST- 2021/07/18 00:00 [revised]
PHST- 2021/09/19 00:00 [accepted]
PHST- 2022/05/23 04:27 [entrez]
PHST- 2022/05/24 06:00 [pubmed]
PHST- 2022/05/24 06:01 [medline]
PHST- 2022/05/01 00:00 [pmc-release]
AID - JISP-26-236 [pii]
AID - 10.4103/jisp.jisp_150_21 [doi]
PST - ppublish
SO  - J Indian Soc Periodontol. 2022 May-Jun;26(3):236-244. doi: 
      10.4103/jisp.jisp_150_21. Epub 2022 May 2.