PMID- 3560258
OWN - NLM
STAT- MEDLINE
DCOM- 19870507
LR  - 20031114
IS  - 0098-4108 (Print)
IS  - 0098-4108 (Linking)
VI  - 20
IP  - 4
DP  - 1987
TI  - Tissue distribution and excretion of tri-(2-ethylhexyl)trimellitate in rats.
PG  - 357-66
AB  - The disposition kinetics of tri-(2-ethylhexyl)trimellitate (TEHTM), a new 
      plasticizer for polyvinyl chloride (PVC) plastic, was studied in rats following 
      intravenous administration of [14C-carbonyl]tri-(2-ethylhexyl)trimellitate using 
      an oil in water emulsion as the vehicle. The distribution half-life, elimination 
      half-life, and clearance values estimated from the plasma concentration of 
      radioactivity data obtained following iv administration of 10.5 mg/kg of TEHTM 
      (59.9 muCi/kg), were 46.2 min, 5.34 d, and 40.5 ml/kg X h, respectively. 
      Following iv dosage of 15.6 mg/kg of TEHTM (28.0 muCi/kg), significant 
      accumulation of radioactivity was found in the liver, lungs, and spleen, with 
      liver accounting for 72% of the administered dosage at 24 h. Excretion of TEHTM 
      and its biotransformation products was slow, with 21.3% of the administered 
      radioactivity found in the feces and 2.8% in the urine during the 14-d collection 
      period. Biliary excretion seems to be the major route of elimination of TEHTM. 
      The pharmacokinetic data gathered in the present investigation are compared to 
      di-(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer for PVC.
FAU - Martis, L
AU  - Martis L
FAU - Freid, E
AU  - Freid E
FAU - Woods, E
AU  - Woods E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Toxicol Environ Health
JT  - Journal of toxicology and environmental health
JID - 7513622
RN  - 0 (Benzoates)
RN  - 3319-31-1 (tri-(2-ethylhexyl)trimellitate)
SB  - IM
MH  - Animals
MH  - Benzoates/*metabolism
MH  - Kinetics
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Tissue Distribution
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
AID - 10.1080/15287398709530989 [doi]
PST - ppublish
SO  - J Toxicol Environ Health. 1987;20(4):357-66. doi: 10.1080/15287398709530989.