PMID- 35603224
OWN - NLM
STAT- MEDLINE
DCOM- 20220524
LR  - 20220716
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 13
DP  - 2022
TI  - Association of Inflammatory Cytokines With Non-Alcoholic Fatty Liver Disease.
PG  - 880298
LID - 10.3389/fimmu.2022.880298 [doi]
LID - 880298
AB  - BACKGROUND: Inflammatory cytokines have been considered to be significant factors 
      contributing to the development and progression of non-alcoholic fatty liver 
      disease (NAFLD). However, the role of inflammatory cytokines in NAFLD remains 
      inconclusive. OBJECTIVE: This study aimed to evaluate the association between 
      inflammatory cytokines and NAFLD. METHODS: PubMed, Web of Science, the Cochrane 
      Library, and EMBASE databases were searched until 31 December 2021 to identify 
      eligible studies that reported the association of inflammatory cytokine with 
      NAFLD and its subtypes. We pooled odds ratios (ORs) and hazard risk (HRs) with 
      95% confidence intervals (CIs) and conducted heterogeneity tests. Sensitivity 
      analysis and analysis for publication bias were also carried out. RESULTS: The 
      search in the databases identified 51 relevant studies that investigated the 
      association between 19 different inflammatory cytokines and NAFLD based on 36,074 
      patients and 47,052 controls. The results of the meta-analysis showed significant 
      associations for C-reactive protein (CRP), interleukin-1beta (IL-1beta), interleukin-6 
      (IL-6), tumor necrosis factor-alpha (TNF-alpha), and intercellular adhesion molecule-1 
      (ICAM-1) with NAFLD (ORs of 1.41, 1.08, 1.50, 1.15 and 2.17, respectively). In 
      contrast, we observed non-significant associations for interferon-gamma (IFN-gamma), 
      insulin-like growth factor (IGF-II), interleukin-2 (IL-2), interleukin-4 (IL-4), 
      interleukin-5 (IL-5), interleukin-7 (IL-7), interleukin-8 (IL-8), interleukin-10 
      (IL-10), interleukin-12 (IL-12), monocyte chemoattractant protein-1(MCP-1), and 
      transforming growth factor-beta (TGF-beta) with NAFLD. Our results also showed that 
      CRP, IL-1beta, and TNF-alpha were significantly associated with non-alcoholic 
      steatohepatitis (NASH) and hepatic fibrosis. CONCLUSIONS: Our results indicated 
      that increased CRP, IL-1beta, IL-6, TNF-alpha, and ICAM-1 concentrations were 
      significantly associated with increased risks of NAFLD. These inflammatory 
      mediators may serve as biomarkers for NAFLD subjects and expect to provide new 
      insights into the aetiology of NAFLD as well as early diagnosis and intervention.
CI  - Copyright (c) 2022 Duan, Pan, Luo, Xiao, Li, Bestman and Luo.
FAU - Duan, Yamei
AU  - Duan Y
AD  - Department of Maternal and Child Health, Xiangya School of Public Health, Central 
      South University, Changsha, China.
FAU - Pan, Xiongfeng
AU  - Pan X
AD  - Department of Maternal and Child Health, Xiangya School of Public Health, Central 
      South University, Changsha, China.
FAU - Luo, Jiayou
AU  - Luo J
AD  - Department of Maternal and Child Health, Xiangya School of Public Health, Central 
      South University, Changsha, China.
FAU - Xiao, Xiang
AU  - Xiao X
AD  - Department of Maternal and Child Health, Xiangya School of Public Health, Central 
      South University, Changsha, China.
FAU - Li, Jingya
AU  - Li J
AD  - Department of Maternal and Child Health, Xiangya School of Public Health, Central 
      South University, Changsha, China.
FAU - Bestman, Prince L
AU  - Bestman PL
AD  - Department of Maternal and Child Health, Xiangya School of Public Health, Central 
      South University, Changsha, China.
FAU - Luo, Miyang
AU  - Luo M
AD  - Department of Epidemiology and Health Statistics, Xiangya School of Public 
      Health, Central South University, Changsha, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20220506
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - C-Reactive Protein
MH  - Cytokines/metabolism
MH  - Humans
MH  - Intercellular Adhesion Molecule-1
MH  - Interleukin-6
MH  - *Non-alcoholic Fatty Liver Disease/pathology
MH  - Tumor Necrosis Factor-alpha
PMC - PMC9122097
OTO - NOTNLM
OT  - hepatic fibrosis
OT  - hepatic steatosis
OT  - inflammatory cytokines
OT  - non-alcoholic fatty liver disease
OT  - non-alcoholic steatohepatitis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/05/24 06:00
MHDA- 2022/05/25 06:00
PMCR- 2022/01/01
CRDT- 2022/05/23 04:36
PHST- 2022/02/21 00:00 [received]
PHST- 2022/04/11 00:00 [accepted]
PHST- 2022/05/23 04:36 [entrez]
PHST- 2022/05/24 06:00 [pubmed]
PHST- 2022/05/25 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2022.880298 [doi]
PST - epublish
SO  - Front Immunol. 2022 May 6;13:880298. doi: 10.3389/fimmu.2022.880298. eCollection 
      2022.