PMID- 35604032
OWN - NLM
STAT- MEDLINE
DCOM- 20220919
LR  - 20221109
IS  - 1552-4981 (Electronic)
IS  - 1552-4973 (Linking)
VI  - 110
IP  - 11
DP  - 2022 Nov
TI  - Electrochemical deposition of lithium coating on titanium implant with enhanced 
      early stage osseointegration.
PG  - 2399-2410
LID - 10.1002/jbm.b.35085 [doi]
AB  - Recently, a large number of studies have reported that lithium (Li) displayed a 
      positive effect on osteogenesis. However, only a few studies have investigated 
      the Li-incorporated surfaces through electrochemical deposition. In this study, 
      electrochemical deposition was conducted on a CHI600E electrochemical 
      workstation. The characterization of electrochemical deposition (ECD) and ECD-Li 
      surfaces were detected by field-emission scanning electron microscopy with 
      energy-dispersive spectrometer. rBMSCs were cultured on two surfaces for 
      subsequent adhesion, proliferation and live/dead assay. To evaluate the effects 
      of Li-incorporated implants by electrochemical deposition on osseointegration in 
      vivo, teeth extraction of two premolars and one first molar in bilateral mandible 
      were performed on six male beagle dogs. After 3 months, ZDI and ZDI-Li implants 
      were inserted into the bilateral mandible of each beagle dog. Micro Computed 
      Tomography (Micro-CT) and hard tissue sectioning analysis were carried out to 
      evaluate the osseointegration at 4- and 8-weeks post-implantation. Results showed 
      that ECD-Li surface promoted adhesion and proliferation of BMSCs in the early 
      stage. More importantly, through micro-CT analysis, the values of bone 
      volume/total volume (BV/TV) (0.374 +/- 0.015), bone-implant contact (BIC) 
      (0.831 +/- 0.025), and Tb.Th (0.412 +/- 0.007) in ZDI-Li group was significantly 
      higher than those of ZDI group (0.302 +/- 0.009, 0.700 +/- 0.023, 0.353 +/- 0.001, 
      p < .01) at 4 weeks. Similarly, ZDI-Li group manifested more bone contact with 
      the implant surfaces at 4 weeks based on hard tissue sectioning analysis, whereas 
      no significant difference was detected between two groups at 8 weeks. Therefore, 
      incorporating Li into implant surface through ECD could enhance early 
      osseointegration in vivo.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Huang, Tingben
AU  - Huang T
AD  - Department of Implantology, Stomatology Hospital, School of Stomatology, Zhejiang 
      University School of Medicine, Zhejiang Provincial Clinical Research Center for 
      Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, 
      Cancer Center of Zhejiang University, Hangzhou, Zhejiang, China.
FAU - Yu, Zhou
AU  - Yu Z
AD  - Department of Implantology, Stomatology Hospital, School of Stomatology, Zhejiang 
      University School of Medicine, Zhejiang Provincial Clinical Research Center for 
      Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, 
      Cancer Center of Zhejiang University, Hangzhou, Zhejiang, China.
FAU - Yu, Qiong
AU  - Yu Q
AD  - Department of Implantology, Stomatology Hospital, School of Stomatology, Zhejiang 
      University School of Medicine, Zhejiang Provincial Clinical Research Center for 
      Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, 
      Cancer Center of Zhejiang University, Hangzhou, Zhejiang, China.
FAU - Chen, Yitong
AU  - Chen Y
AD  - Department of Implantology, Stomatology Hospital, School of Stomatology, Zhejiang 
      University School of Medicine, Zhejiang Provincial Clinical Research Center for 
      Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, 
      Cancer Center of Zhejiang University, Hangzhou, Zhejiang, China.
FAU - Jiang, Zhiwei
AU  - Jiang Z
AD  - Department of Implantology, Stomatology Hospital, School of Stomatology, Zhejiang 
      University School of Medicine, Zhejiang Provincial Clinical Research Center for 
      Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, 
      Cancer Center of Zhejiang University, Hangzhou, Zhejiang, China.
FAU - Wang, Ying
AU  - Wang Y
AD  - Department of Oral Medicine, Stomatology Hospital, School of Stomatology, 
      Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research 
      Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang 
      Province, Cancer Center of Zhejiang University, Hangzhou, Zhejiang, China.
FAU - Yang, Guoli
AU  - Yang G
AUID- ORCID: 0000-0002-1780-8757
AD  - Department of Implantology, Stomatology Hospital, School of Stomatology, Zhejiang 
      University School of Medicine, Zhejiang Provincial Clinical Research Center for 
      Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, 
      Cancer Center of Zhejiang University, Hangzhou, Zhejiang, China.
LA  - eng
GR  - 2020KY624/Department of Health of Zhejiang Province/
GR  - 2020RC023/Department of Health of Zhejiang Province/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220523
PL  - United States
TA  - J Biomed Mater Res B Appl Biomater
JT  - Journal of biomedical materials research. Part B, Applied biomaterials
JID - 101234238
RN  - 0 (Dental Implants)
RN  - 9FN79X2M3F (Lithium)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Animals
MH  - *Dental Implants
MH  - Dogs
MH  - Lithium
MH  - Male
MH  - *Osseointegration
MH  - Osteogenesis
MH  - Surface Properties
MH  - Titanium/pharmacology
MH  - X-Ray Microtomography
OTO - NOTNLM
OT  - beagle dog
OT  - electrochemical deposition
OT  - lithium
OT  - osseointegration
OT  - titanium implant
EDAT- 2022/05/24 06:00
MHDA- 2022/09/20 06:00
CRDT- 2022/05/23 08:03
PHST- 2022/04/19 00:00 [revised]
PHST- 2021/05/03 00:00 [received]
PHST- 2022/04/30 00:00 [accepted]
PHST- 2022/05/24 06:00 [pubmed]
PHST- 2022/09/20 06:00 [medline]
PHST- 2022/05/23 08:03 [entrez]
AID - 10.1002/jbm.b.35085 [doi]
PST - ppublish
SO  - J Biomed Mater Res B Appl Biomater. 2022 Nov;110(11):2399-2410. doi: 
      10.1002/jbm.b.35085. Epub 2022 May 23.