PMID- 35604582
OWN - NLM
STAT- MEDLINE
DCOM- 20220711
LR  - 20220712
IS  - 1573-2584 (Electronic)
IS  - 0301-1623 (Linking)
VI  - 54
IP  - 8
DP  - 2022 Aug
TI  - Effects of vitamin E and vitamin C on male infertility: a meta-analysis.
PG  - 1793-1805
LID - 10.1007/s11255-022-03237-x [doi]
AB  - PURPOSE: The efficacy of the antioxidants vitamin E (VitE) and vitamin C (VitC) 
      on male infertility is uncertain. Therefore, this research systematically 
      assessed the influences of VitE and VitC on male infertility. METHODS: We did a 
      meta-analysis of randomized controlled trials (RCTs) to analyze semen parameters, 
      pregnancy rate, and adverse effects (AEs) between VitE and VitC groups and 
      control groups by searching Cochrane Library, Excerpta Medica Database (Embase), 
      PubMed, China Biology Medicine disc (CBMdisc), and Web of Science up to June 
      2020. RESULTS: We screened 11 studies (832 patients) that met the inclusion 
      criteria. The evidence quality ranged from moderate to low. The pregnancy rate 
      was obviously better in the VitE group than in the control group (relative risk 
      (RR) 1.86, 95% confidence interval (CI) 1.02-3.41). Compared with the control 
      group, VitE and VitC significantly improved progressive motility (standardized 
      mean difference (SMD) 0.38, 95% CI 0.22-0.55), sperm concentration (SMD 0.21, 95% 
      CI 0.09-0.34), sperm morphology (SMD 0.32, 95% CI 0.09-0.55), and total sperm 
      number (SMD 0.28, 95% CI 0.12-0.43) without AEs. CONCLUSION: This study suggests 
      that VitC and VitE can improve the spousal pregnancy rate and semen parameters in 
      infertile men without AEs.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Zhou, Xianling
AU  - Zhou X
AUID- ORCID: 0000-0002-2087-3322
AD  - Department of Nephrology, The First Affiliated Hospital of Jinan University, 
      Guangzhou, Guangdong, China.
FAU - Shi, Heng
AU  - Shi H
AD  - Department of Nephrology, The First Affiliated Hospital of Jinan University, 
      Guangzhou, Guangdong, China.
FAU - Zhu, Shiping
AU  - Zhu S
AD  - Department of Traditional Chinese Medicine, The First Affiliated Hospital of 
      Jinan University, 613 Huangpu Avenue West, Guangzhou, 510630, Guangdong, China.
FAU - Wang, Haixia
AU  - Wang H
AD  - Department of Traditional Chinese Medicine, The First Affiliated Hospital of 
      Jinan University, 613 Huangpu Avenue West, Guangzhou, 510630, Guangdong, China.
FAU - Sun, Shengyun
AU  - Sun S
AD  - Department of Traditional Chinese Medicine, The First Affiliated Hospital of 
      Jinan University, 613 Huangpu Avenue West, Guangzhou, 510630, Guangdong, China. 
      shengyunsun2020@163.com.
LA  - eng
GR  - 20203005/Traditional Chinese Medicine Bureau of Guangdong Province/
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20220523
PL  - Netherlands
TA  - Int Urol Nephrol
JT  - International urology and nephrology
JID - 0262521
RN  - 0 (Vitamins)
RN  - 1406-18-4 (Vitamin E)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Ascorbic Acid/therapeutic use
MH  - Female
MH  - Humans
MH  - *Infertility, Male/drug therapy
MH  - Male
MH  - Pregnancy
MH  - Randomized Controlled Trials as Topic
MH  - Semen
MH  - Sperm Count
MH  - *Vitamin E/therapeutic use
MH  - Vitamins/pharmacology/therapeutic use
OTO - NOTNLM
OT  - Male infertility
OT  - Meta-analysis
OT  - Vitamin C
OT  - Vitamin E
EDAT- 2022/05/24 06:00
MHDA- 2022/07/12 06:00
CRDT- 2022/05/23 11:19
PHST- 2022/04/10 00:00 [received]
PHST- 2022/05/05 00:00 [accepted]
PHST- 2022/05/24 06:00 [pubmed]
PHST- 2022/07/12 06:00 [medline]
PHST- 2022/05/23 11:19 [entrez]
AID - 10.1007/s11255-022-03237-x [pii]
AID - 10.1007/s11255-022-03237-x [doi]
PST - ppublish
SO  - Int Urol Nephrol. 2022 Aug;54(8):1793-1805. doi: 10.1007/s11255-022-03237-x. Epub 
      2022 May 23.