PMID- 35604969 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20221031 LR - 20221031 IS - 1558-254X (Electronic) IS - 0278-0062 (Linking) VI - 41 IP - 11 DP - 2022 Nov TI - Anti-Interference From Noisy Labels: Mean-Teacher-Assisted Confident Learning for Medical Image Segmentation. PG - 3062-3073 LID - 10.1109/TMI.2022.3176915 [doi] AB - Manually segmenting medical images is expertise-demanding, time-consuming and laborious. Acquiring massive high-quality labeled data from experts is often infeasible. Unfortunately, without sufficient high-quality pixel-level labels, the usual data-driven learning-based segmentation methods often struggle with deficient training. As a result, we are often forced to collect additional labeled data from multiple sources with varying label qualities. However, directly introducing additional data with low-quality noisy labels may mislead the network training and undesirably offset the efficacy provided by those high-quality labels. To address this issue, we propose a Mean-Teacher-assisted Confident Learning (MTCL) framework constructed by a teacher-student architecture and a label self-denoising process to robustly learn segmentation from a small set of high-quality labeled data and plentiful low-quality noisy labeled data. Particularly, such a synergistic framework is capable of simultaneously and robustly exploiting (i) the additional dark knowledge inside the images of low-quality labeled set via perturbation-based unsupervised consistency, and (ii) the productive information of their low-quality noisy labels via explicit label refinement. Comprehensive experiments on left atrium segmentation with simulated noisy labels and hepatic and retinal vessel segmentation with real-world noisy labels demonstrate the superior segmentation performance of our approach as well as its effectiveness on label denoising. FAU - Xu, Zhe AU - Xu Z FAU - Lu, Donghuan AU - Lu D FAU - Luo, Jie AU - Luo J FAU - Wang, Yixin AU - Wang Y FAU - Yan, Jiangpeng AU - Yan J FAU - Ma, Kai AU - Ma K FAU - Zheng, Yefeng AU - Zheng Y FAU - Tong, Raymond Kai-Yu AU - Tong RK LA - eng PT - Journal Article DEP - 20221027 PL - United States TA - IEEE Trans Med Imaging JT - IEEE transactions on medical imaging JID - 8310780 SB - IM EDAT- 2022/05/24 06:00 MHDA- 2022/05/24 06:01 CRDT- 2022/05/23 13:54 PHST- 2022/05/24 06:00 [pubmed] PHST- 2022/05/24 06:01 [medline] PHST- 2022/05/23 13:54 [entrez] AID - 10.1109/TMI.2022.3176915 [doi] PST - ppublish SO - IEEE Trans Med Imaging. 2022 Nov;41(11):3062-3073. doi: 10.1109/TMI.2022.3176915. Epub 2022 Oct 27.