PMID- 35605654
OWN - NLM
STAT- MEDLINE
DCOM- 20220628
LR  - 20220824
IS  - 1678-4391 (Electronic)
IS  - 1413-8670 (Print)
IS  - 1413-8670 (Linking)
VI  - 26
IP  - 3
DP  - 2022 May-Jun
TI  - Guillain-Barre syndrome spectrum as manifestation of HIV-related immune 
      reconstitution inflammatory syndrome: case report and literature review.
PG  - 102368
LID - S1413-8670(22)00056-3 [pii]
LID - 10.1016/j.bjid.2022.102368 [doi]
LID - 102368
AB  - A 34-year-old man presented with a history of 21-days of gait unsteadiness and 
      diplopia. Ten days before presentation, he developed limb weakness and in the 
      last three days reduced consciousness. HIV infection was diagnosed three months 
      ago (CD4+ = 160 cells/mm(3); viral load HIV-1 = 144.000 copies/mL), and 
      antiretroviral therapy was initiated. Impaired consciousness, ophthalmoplegia, 
      limb weakness, ataxia, areflexia, and Babinsky s sign were noted. At that moment, 
      CD4+ count was 372 cells/mm 3 and viral load HIV-1 <50 copies/mL. The clinical, 
      laboratory and neurophysiological findings suggest overlapping Guillain-Barre 
      syndrome (GBS) and Bickerstaff brainstem encephalitis as manifestation of 
      HIV-related immune reconstitution inflammatory syndrome (IRIS). Here, we review 
      and discuss 7 cases (including the present report) of GBS spectrum as 
      manifestation of HIV-related IRIS.
CI  - Copyright (c) 2022 Sociedade Brasileira de Infectologia. Published by Elsevier 
      Espana, S.L.U. All rights reserved.
FAU - Vidal, Jose E
AU  - Vidal JE
AD  - Instituto de Infectologia Emilio Ribas, Sao Paulo, SP, Brazil; Hospital das 
      Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, 
      Brazil; Instituto de Medicina Tropical da Universidade de Sao Paulo, Sao Paulo, 
      SP, Brazil. Electronic address: josevibe@gmail.com.
FAU - Guedes, Bruno F
AU  - Guedes BF
AD  - Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao 
      Paulo, SP, Brazil.
FAU - Gomes, Helio R
AU  - Gomes HR
AD  - Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao 
      Paulo, SP, Brazil.
FAU - Mendonca, Rodrigo Holanda
AU  - Mendonca RH
AD  - Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao 
      Paulo, SP, Brazil.
LA  - eng
PT  - Case Reports
PT  - Review
DEP - 20220521
PL  - Brazil
TA  - Braz J Infect Dis
JT  - The Brazilian journal of infectious diseases : an official publication of the 
      Brazilian Society of Infectious Diseases
JID - 9812937
SB  - IM
MH  - Adult
MH  - CD4 Lymphocyte Count
MH  - *Encephalitis/diagnosis
MH  - *Guillain-Barre Syndrome/diagnosis/etiology
MH  - *HIV Infections/complications/drug therapy
MH  - Humans
MH  - *Immune Reconstitution Inflammatory Syndrome/etiology
MH  - Male
PMC - PMC9387489
OTO - NOTNLM
OT  - Guillain-Barre syndrome
OT  - HIV-1
OT  - Immune reconstitution inflammatory syndrome
OT  - Peripheral neuropathy
COIS- Conflicts of interest The authors declare no conflicts of interest.
EDAT- 2022/05/24 06:00
MHDA- 2022/06/29 06:00
PMCR- 2022/05/21
CRDT- 2022/05/23 19:23
PHST- 2022/02/13 00:00 [received]
PHST- 2022/04/30 00:00 [accepted]
PHST- 2022/05/24 06:00 [pubmed]
PHST- 2022/06/29 06:00 [medline]
PHST- 2022/05/23 19:23 [entrez]
PHST- 2022/05/21 00:00 [pmc-release]
AID - S1413-8670(22)00056-3 [pii]
AID - 102368 [pii]
AID - 10.1016/j.bjid.2022.102368 [doi]
PST - ppublish
SO  - Braz J Infect Dis. 2022 May-Jun;26(3):102368. doi: 10.1016/j.bjid.2022.102368. 
      Epub 2022 May 21.