PMID- 35607553
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 14
IP  - 4
DP  - 2022 Apr
TI  - Acute Presentation of Newly Diagnosed Multiple Sclerosis Associated With 
      Polymerase Chain Reaction-Proven Human Herpesvirus 6 Central Nervous System 
      Infection.
PG  - e24319
LID - 10.7759/cureus.24319 [doi]
LID - e24319
AB  - We present the case of a 26-year-old male who was found to have human herpesvirus 
      6 (HHV-6) in his cerebrospinal fluid (CSF) during acute presentation of multiple 
      sclerosis (MS). Paresthesia of the lower extremities was his only symptom during 
      the initial presentation, and workup for MS was not included during this 
      evaluation. A single dose of IV steroids failed to improve his condition, and 
      symptoms became more severe. Upon secondary evaluation, MRI revealed white-matter 
      disease with plaques at multiple levels of the cervical spine and central nervous 
      system (CNS). Lumbar puncture was obtained, and CSF analysis was positive for 
      HHV-6 DNA. After five days of oral steroid treatment and physical therapy for 
      three weeks, his symptoms continued to worsen. MRI at this time demonstrated an 
      increase in the size of previous plaques and new foci of white matter disease. 
      Repeat CSF analysis was negative for HHV-6. The virus' association with relapse 
      of MS has been investigated by many studies. However, there is a lack of 
      literature investigating its role in causing MS disease. In this case report, we 
      highlight the need for further research aimed at determining if HHV-6 is an 
      environmental trigger for MS disease onset.
CI  - Copyright (c) 2022, Pumphrey et al.
FAU - Pumphrey, Conor M
AU  - Pumphrey CM
AD  - Medicine, Brody School of Medicine, Greenville, USA.
FAU - Scarcella, Joshua F
AU  - Scarcella JF
AD  - Plastic and Reconstructive Surgery, Brody School of Medicine, Greenville, USA.
FAU - Price, Donald L Jr
AU  - Price DL Jr
AD  - Neurology, Vidant Medical Center/East Carolina University, Greenville, USA.
LA  - eng
PT  - Case Reports
DEP - 20220420
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC9122541
OTO - NOTNLM
OT  - hhv-6
OT  - human herpesvirus 6
OT  - ms
OT  - multiple sclerosis
OT  - relapse
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/05/25 06:00
MHDA- 2022/05/25 06:01
PMCR- 2022/04/20
CRDT- 2022/05/24 01:59
PHST- 2022/04/19 00:00 [accepted]
PHST- 2022/05/24 01:59 [entrez]
PHST- 2022/05/25 06:00 [pubmed]
PHST- 2022/05/25 06:01 [medline]
PHST- 2022/04/20 00:00 [pmc-release]
AID - 10.7759/cureus.24319 [doi]
PST - epublish
SO  - Cureus. 2022 Apr 20;14(4):e24319. doi: 10.7759/cureus.24319. eCollection 2022 
      Apr.