PMID- 35608027 OWN - NLM STAT- MEDLINE DCOM- 20220525 LR - 20230916 IS - 1552-695X (Electronic) IS - 1534-7354 (Print) IS - 1534-7354 (Linking) VI - 21 DP - 2022 Jan-Dec TI - Electroacupuncture for Cancer-Related Cognitive Impairment: A Clinical Feasibility Study. PG - 15347354221098983 LID - 10.1177/15347354221098983 [doi] LID - 15347354221098983 AB - BACKGROUND: Cancer-related cognitive impairment (CRCI) is a significant problem for cancer patients, as the number of cancer survivors experiencing cognitive impairments is increasing in the absence of standard treatment. There have been attempts to improve the cognitive function of patients with cancer using acupuncture; however, no studies have been conducted using electroacupuncture. Thus, we designed a preliminary study to investigate the feasibility of a clinical trial using electroacupuncture in CRCI patients. METHODS: We conducted a single-arm, pilot, clinical trial to investigate the feasibility of a study protocol for further large-scale clinical trials of electroacupuncture in CRCI patients. All participants were treated with electroacupuncture twice a week for 30 minutes at a time, for 8 weeks on acupoints GV20, GV24, EX-HN1, and GB20, HT7, PC6, and KI3. Both subjective and objective outcomes of cognitive function, quality of life (QoL), and psychological factors were measured in all participants at baseline, week 4, 8, and 12. For safety assessment, vital signs, laboratory examinations, and adverse events (AEs) were observed throughout the trial. RESULTS: A total of 12 participants were enrolled at Daejeon and Dunsan Korean Medicine Hospital of Daejeon University from 21 April 2017 to 31 January 2018. After 8 weeks of treatment, electroacupuncture significantly improved both subjective and objective cognitive outcomes, including the perceived cognitive impairments scale of the Functional Assessment of Cancer Therapy-Cognitive Function, QoL scale of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire-C30, Korean version of Montreal Cognitive Assessment, Boston Naming Test, Seoul Verbal Learning Test, and Rey Complex Figure Test. During the entire trial period, 19 AEs were observed, with no serious AEs. Additionally, it was found that all feasibility outcomes, including recruitment, completion, and adherence rates, achieved successful results as the ratio exceeded 0.8. CONCLUSION: Our study results revealed that electroacupuncture improved cognitive complaints in cancer patients, and we expect electroacupuncture to be a safe and effective management therapy for CRCI patients. These feasibility trial results will be used as preliminary data for future randomized controlled clinical trials. TRIAL REGISTRATION NUMBER: Korean Clinical Trial Registry (KCT0002168). FAU - Lyu, Yee Ran AU - Lyu YR AD - Korea Institute of Oriental Medicine, Daejeon, Republic of Korea. FAU - Lee, Hye-Yoon AU - Lee HY AD - Pusan National University, Yangsan, Republic of Korea. FAU - Park, Hyo-Ju AU - Park HJ AD - Korea Institute of Oriental Medicine, Daejeon, Republic of Korea. FAU - Kwon, O-Jin AU - Kwon OJ AD - Korea Institute of Oriental Medicine, Daejeon, Republic of Korea. FAU - Kim, Ae-Ran AU - Kim AR AD - Korea Institute of Oriental Medicine, Daejeon, Republic of Korea. FAU - Jung, In Chul AU - Jung IC AD - Daejeon University, Daejeon, Republic of Korea. FAU - Park, Yang-Chun AU - Park YC AD - Daejeon University, Daejeon, Republic of Korea. FAU - Cho, Jung-Hyo AU - Cho JH AD - Daejeon University, Daejeon, Republic of Korea. FAU - Kim, Jung-Eun AU - Kim JE AD - Pusan National University Hospital, Busan, Republic of Korea. FAU - Kim, Mikyung AU - Kim M AD - Sangji University, Wonju, Gangwon-do, Republic of Korea. FAU - Lee, Jun-Hwan AU - Lee JH AD - Korea Institute of Oriental Medicine, Daejeon, Republic of Korea. AD - University of Science & Technology (UST) Daejeon, Republic of Korea. FAU - Kim, Joo-Hee AU - Kim JH AUID- ORCID: 0000-0003-1435-5649 AD - Sangji University, Wonju, Gangwon-do, Republic of Korea. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Integr Cancer Ther JT - Integrative cancer therapies JID - 101128834 SB - IM MH - *Cognitive Dysfunction/etiology/therapy MH - *Electroacupuncture/methods MH - Feasibility Studies MH - Humans MH - *Neoplasms/complications MH - Quality of Life MH - Treatment Outcome PMC - PMC9134458 OTO - NOTNLM OT - cancer OT - cancer-related cognitive impairment OT - electroacupuncture OT - feasibility clinical trial OT - integrative medicine COIS- Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2022/05/25 06:00 MHDA- 2022/05/26 06:00 PMCR- 2022/05/24 CRDT- 2022/05/24 05:23 PHST- 2022/05/24 05:23 [entrez] PHST- 2022/05/25 06:00 [pubmed] PHST- 2022/05/26 06:00 [medline] PHST- 2022/05/24 00:00 [pmc-release] AID - 10.1177_15347354221098983 [pii] AID - 10.1177/15347354221098983 [doi] PST - ppublish SO - Integr Cancer Ther. 2022 Jan-Dec;21:15347354221098983. doi: 10.1177/15347354221098983.