PMID- 35610014
OWN - NLM
STAT- MEDLINE
DCOM- 20220526
LR  - 20230415
IS  - 2589-451X (Electronic)
IS  - 0255-2922 (Print)
IS  - 0255-2922 (Linking)
VI  - 42
IP  - 3
DP  - 2022 Jun
TI  - Effectiveness of Zhuling decoction on diuretic resistance in patients with heart 
      failure: a randomized, controlled trial.
PG  - 439-445
LID - 10.19852/j.cnki.jtcm.20220311.003 [doi]
AB  - OBJECTIVE: To test the effects of Zhuling decoction on patients with diuretic 
      resistance in heart failure compared with a group of patients undergoing 
      conventional treatment alone. METHODS: This research was a prospective, 
      randomized, controlled study. From July 2018 to August 2020, 96 diuretic 
      resistance patients from the Cardiovascular Research Center of Taicang Hospital 
      affiliated with Nanjing University of Traditional Chinese Medicine (Grade III 
      Hospital of Traditional Chinese Medicine) were enrolled in the study. The 
      subjects were randomly divided into an observation group (48 cases) and a control 
      group (48 cases). Patients in both groups received conventional treatment. In 
      addition, observation group patients received Traditional Chinese Medicine 
      Zhuling decoction. The primary endpoint was the urine output mean difference 
      between Day 1 and Day 7 after treatment. Secondary endpoints were the changes 
      over time in the N-terminal pro-B type natriuretic peptide (NT-proBNP), New York 
      Heart Association (NYHA) functional classification, and Minnesota Living with 
      Heart Failure Questionnaire (MLHFQ). The safety and tolerability of the drug were 
      comprehensively evaluated based on adverse drug reactions, as well as 
      laboratory-assisted tests for liver and kidney function and electrolytes. 
      RESULTS: Significant improvements were demonstrated for urine output in the two 
      groups at Day 7, with a 1325 1045 mL difference in favor of the observation group 
      ( = 0.018). The observation group also had greater improvements in NT-proBNP and 
      NYHA functional classification changes than the control group. At the 30th day of 
      follow-up, a significant reduction in negative findings on the MLHFQ from 
      baseline was observed in both groups, but the observation group demonstrated a 
      significantly greater reduction than the control group ( <0.001). CONCLUSIONS: 
      Zhuling decoction could be used in combination therapy for patients with diuretic 
      resistance in heart failure in addition to standard treatment.
FAU - Yunhu, Chen
AU  - Yunhu C
AD  - Department of Cardiovascular, Taicang Hospital affiliated with Nanjing University 
      of Traditional Chinese Medicine, Suzhou 215400, China.
FAU - Lihua, Fan
AU  - Lihua F
AD  - Department of Cardiovascular, Taicang Hospital affiliated with Nanjing University 
      of Traditional Chinese Medicine, Suzhou 215400, China.
FAU - Tao, Zhang
AU  - Tao Z
AD  - Department of Cardiovascular, Changzhou Hospital affiliated with Nanjing 
      University of Traditional Chinese Medicine, Changzhou 213003, China.
FAU - Xueqian, Liu
AU  - Xueqian L
AD  - Department of Cardiovascular, Taicang Hospital affiliated with Nanjing University 
      of Traditional Chinese Medicine, Suzhou 215400, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - J Tradit Chin Med
JT  - Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
JID - 8211546
RN  - 0 (Diuretics)
RN  - 0 (Peptide Fragments)
SB  - IM
MH  - *Diuretics/therapeutic use
MH  - *Heart Failure/drug therapy
MH  - Humans
MH  - Medicine, Chinese Traditional
MH  - Peptide Fragments/therapeutic use
MH  - Prospective Studies
PMC - PMC9924782
OTO - NOTNLM
OT  - Zhuling decoction
OT  - diuretic resistance
OT  - heart failure
OT  - randomized controlled trial
OT  - treatment outcome
OT  - urine output
EDAT- 2022/05/25 06:00
MHDA- 2022/05/27 06:00
PMCR- 2022/06/15
CRDT- 2022/05/24 21:44
PHST- 2022/05/24 21:44 [entrez]
PHST- 2022/05/25 06:00 [pubmed]
PHST- 2022/05/27 06:00 [medline]
PHST- 2022/06/15 00:00 [pmc-release]
AID - 1653378009687-1041098193 [pii]
AID - 0255-2922-42-3-439 [pii]
AID - 10.19852/j.cnki.jtcm.20220311.003 [doi]
PST - ppublish
SO  - J Tradit Chin Med. 2022 Jun;42(3):439-445. doi: 
      10.19852/j.cnki.jtcm.20220311.003.