PMID- 35610031
OWN - NLM
STAT- MEDLINE
DCOM- 20220622
LR  - 20230322
IS  - 1943-3654 (Electronic)
IS  - 0020-1324 (Linking)
VI  - 67
IP  - 7
DP  - 2022 Jul
TI  - Isolated Elevation in Lung Residual Volume Is Associated With Airway Diseases.
PG  - 842-849
LID - 10.4187/respcare.09687 [doi]
AB  - BACKGROUND: Residual volume (RV) is a derived lung compartment that correlates 
      with air trapping in the context of air flow obstruction on spirometry. The 
      significance of an isolated elevation in RV in the absence of other pulmonary 
      function test (PFT) abnormalities is not well defined. We sought to assess the 
      clinical and radiologic findings associated with isolated elevation in RV. 
      METHODS: We searched our out-patient PFT database at Mayo Clinic (Rochester, 
      Minnesota) from 2016-2018 for adult patients with isolated elevation in RV. We 
      defined isolated elevation in RV as RV >/= upper limit of normal or >/= 130% 
      predicted with normal total lung capacity (TLC), spirometry, and diffusion 
      capacity of the lung for carbon monoxide (D(LCO)). We then matched this high-RV 
      group by age and sex to an equal number of individuals with normal RV, TLC, 
      spirometry, and D(LCO) (normal-RV group). RESULTS: We identified 169 subjects 
      with isolated elevation in RV on PFTs, with a median age of 73 y; 55.6% were 
      female, and median body mass index was 26.8 (vs 29.8 in the normal-RV group). The 
      median RV was 3.08 L (134% predicted, interquartile range [IQR] 130-141) in the 
      high-RV group and 2.26 L (99% predicted, IQR 90-109) in the normal-RV group (P < 
      .001). Subjects with high RV were more likely to have smoked (54% vs 40%, P = 
      .01) and almost twice as likely to have a maximum voluntary ventilation < 30 
      times the FEV(1) (21% vs 12%, P = .02). Clinically, asthma (21% vs 11%, P = .01) 
      and non-tuberculous mycobacterial lung infections (12% vs 2%, P = .001) were more 
      prevalent in the high-RV group. On chest computed tomography, bronchiectasis (31% 
      vs 15%, P = .008), bronchial thickening or mucus plugging (46% vs 22%, P < .001), 
      and emphysema (13% vs 5%, P = .046) were more common in the high-RV group. 
      CONCLUSIONS: Isolated elevation in RV on PFTs is a clinically relevant 
      abnormality associated with airway-centered diseases.
CI  - Copyright (c) 2022 by Daedalus Enterprises.
FAU - Kanj, Amjad N
AU  - Kanj AN
AD  - Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, 
      Minnesota.
FAU - Samhouri, Bilal F
AU  - Samhouri BF
AD  - Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, 
      Minnesota.
FAU - Poliszuk, Daniel
AU  - Poliszuk D
AD  - Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, 
      Minnesota.
FAU - Lim, Kaiser G
AU  - Lim KG
AD  - Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, 
      Minnesota.
FAU - Hoskote, Sumedh S
AU  - Hoskote SS
AD  - Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, 
      Minnesota. Hoskote.sumedh@mayo.edu.
LA  - eng
PT  - Journal Article
DEP - 20220524
PL  - United States
TA  - Respir Care
JT  - Respiratory care
JID - 7510357
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Lung/diagnostic imaging
MH  - Male
MH  - *Pulmonary Emphysema
MH  - Residual Volume
MH  - *Respiration Disorders
MH  - Respiratory Function Tests
MH  - Spirometry/methods
OTO - NOTNLM
OT  - asthma
OT  - pulmonary function test
OT  - residual volume
COIS- The authors have disclosed no conflicts of interest.
EDAT- 2022/05/25 06:00
MHDA- 2022/06/23 06:00
CRDT- 2022/05/24 21:45
PHST- 2022/05/25 06:00 [pubmed]
PHST- 2022/06/23 06:00 [medline]
PHST- 2022/05/24 21:45 [entrez]
AID - respcare.09687 [pii]
AID - 10.4187/respcare.09687 [doi]
PST - ppublish
SO  - Respir Care. 2022 Jul;67(7):842-849. doi: 10.4187/respcare.09687. Epub 2022 May 
      24.