PMID- 3561171
OWN - NLM
STAT- MEDLINE
DCOM- 19870521
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 40
IP  - 17
DP  - 1987 Apr 27
TI  - Central muscarinic control of the pattern of small intestinal motility in rats.
PG  - 1709-15
AB  - The effects of central and peripheral administration of muscarinic agonists and 
      antagonists on small intestinal motility were examined in conscious rats 
      chronically fitted with electrodes implanted in the duodeno-jejunal wall and a 
      cannula in a cerebral lateral ventricle. Intracerebroventricular (i.c.v.) 
      administration of either atropine or pirenzepine at doses from 1 to 10 
      micrograms, 15 min before a 3 and 6 g lab chow meal significantly reduced the 
      duration of the postprandial disruption of the migrating myoelectric complexes 
      (MMC). The reduction was significantly greater for atropine, a mixed M1 and M2 
      muscarinic receptor antagonist, than for pirenzepine, an antagonist with a high 
      affinity for M1 receptors. At a higher dose (10 micrograms) intra peritoneal 
      (i.p.) administration of atropine or pirenzepine did not modify the postprandial 
      disruption of MMC. Oxotremorine (10 ng) a M2 agonist, but not McNeil A343 (5 
      micrograms), a selective M1 agonist, given i.c.v. in fasted rats disrupted for 
      1.5 h the MMC pattern. At the same doses given i.p. oxotremorine and McNeil A343 
      disrupted the MMC for 15 and 45 min respectively. We conclude that the 
      postprandial changes in the small intestinal motility involve muscarinic 
      receptors, mainly of M2 subtype, at the level of the central nervous system.
FAU - Fargeas, M J
AU  - Fargeas MJ
FAU - Fioramonti, J
AU  - Fioramonti J
FAU - Bueno, L
AU  - Bueno L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Receptors, Muscarinic)
RN  - 3G0285N20N (Pirenzepine)
RN  - 5RY0UWH1JL (Oxotremorine)
RN  - 7C0697DR9I (Atropine)
SB  - IM
MH  - Animals
MH  - Atropine/pharmacology
MH  - Brain/physiology
MH  - Electromyography
MH  - *Gastrointestinal Motility/drug effects
MH  - Injections, Intraperitoneal
MH  - Injections, Intraventricular
MH  - Intestine, Small/physiology
MH  - Male
MH  - Oxotremorine/pharmacology
MH  - Parasympathetic Nervous System/physiology
MH  - Pirenzepine/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Muscarinic/drug effects/*physiology
EDAT- 1987/04/27 00:00
MHDA- 1987/04/27 00:01
CRDT- 1987/04/27 00:00
PHST- 1987/04/27 00:00 [pubmed]
PHST- 1987/04/27 00:01 [medline]
PHST- 1987/04/27 00:00 [entrez]
AID - 0024-3205(87)90021-X [pii]
AID - 10.1016/0024-3205(87)90021-x [doi]
PST - ppublish
SO  - Life Sci. 1987 Apr 27;40(17):1709-15. doi: 10.1016/0024-3205(87)90021-x.