PMID- 35612560
OWN - NLM
STAT- MEDLINE
DCOM- 20220830
LR  - 20230203
IS  - 1536-7355 (Electronic)
IS  - 1076-1608 (Print)
IS  - 1076-1608 (Linking)
VI  - 28
IP  - 6
DP  - 2022 Sep 1
TI  - Antineutrophil Cytoplasmic Antibody-Associated Vasculitis and COVID-19: The 
      Clinical Course and Prognosis of 15 Patients From a Tertiary Care Center.
PG  - 300-304
LID - 10.1097/RHU.0000000000001855 [doi]
AB  - OBJECTIVE: The aim of this study was to evaluate incidence rates, prognoses, and 
      disease-related factors associated with poor outcomes in patients with 
      antineutrophil cytoplasmic antibody-associated vasculitis (AAV) who had 
      coronavirus disease (COVID-19). METHODS: Patients with AAV were questioned for a 
      history of COVID-19 in the outpatient setting. Cumulative clinical findings and 
      treatment history were obtained from the patients' medical records. The clinical, 
      laboratory, and imaging findings of inpatients with COVID-19 were recorded. The 
      data of patients who developed symptomatic COVID-19 and/or died of the disease 
      were used for comparison. RESULTS: Eighty-nine patients (47.2% female; mean age, 
      56 +/- 12.5 years) were included. The diagnosis was granulomatosis with 
      polyangiitis in 56 patients (62.9%) and microscopic polyangiitis in 33 (37.1%). 
      Sixty-one (68.2%) and 21 patients (23.6%) had renal and peripheral nerve 
      involvement, respectively. Ten patients had a history of diffuse alveolar 
      hemorrhage. Fifteen patients (16.9%) had COVID-19, including 9 (60%) with severe 
      pneumonia. Twelve patients (85.7%) were hospitalized, 6 (42.9%) were admitted to 
      the intensive care unit, and 5 (35.7%) died. All deceased patients had 
      hypogammaglobulinemia (IgG levels <700 mg/dL) during hospital admission. 
      Symptomatic COVID-19 was associated with higher disease activity, glucocorticoid 
      and rituximab treatments, and glomerular filtration rate <30 mL/min. A history of 
      peripheral nerve involvement, higher organ damage scores, and 
      hypogammaglobulinemia was associated with mortality. CONCLUSIONS: The prognosis 
      was poor in our patients with AAV who had COVID-19, especially those with severe 
      multisystem involvement. Hypogammaglobulinemia was associated with mortality. 
      Serum IgG level monitoring in patients with AAV would be beneficial during the 
      COVID-19 pandemic.
CI  - Copyright (c) 2022 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Ince, Burak
AU  - Ince B
AD  - From the Division of Rheumatology, Department of Internal Medicine, Istanbul 
      Faculty of Medicine.
FAU - Bektas, Murat
AU  - Bektas M
AD  - From the Division of Rheumatology, Department of Internal Medicine, Istanbul 
      Faculty of Medicine.
FAU - Koca, Nevzat
AU  - Koca N
AD  - From the Division of Rheumatology, Department of Internal Medicine, Istanbul 
      Faculty of Medicine.
FAU - Agargun, Besim Fazil
AU  - Agargun BF
AD  - Department of Internal Medicine, Istanbul Faculty of Medicine.
FAU - Zarali, Sibel
AU  - Zarali S
AD  - Department of Internal Medicine, Istanbul Faculty of Medicine.
FAU - Guzey, Damla Yenersu
AU  - Guzey DY
AD  - Istanbul Faculty of Medicine.
FAU - Durak, Gorkem
AU  - Durak G
AD  - Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Yalcinkaya, Yasemin
AU  - Yalcinkaya Y
AD  - From the Division of Rheumatology, Department of Internal Medicine, Istanbul 
      Faculty of Medicine.
FAU - Artim-Esen, Bahar
AU  - Artim-Esen B
AD  - From the Division of Rheumatology, Department of Internal Medicine, Istanbul 
      Faculty of Medicine.
FAU - Gul, Ahmet
AU  - Gul A
AD  - From the Division of Rheumatology, Department of Internal Medicine, Istanbul 
      Faculty of Medicine.
FAU - Inanc, Murat
AU  - Inanc M
AD  - From the Division of Rheumatology, Department of Internal Medicine, Istanbul 
      Faculty of Medicine.
LA  - eng
PT  - Journal Article
DEP - 20220525
PL  - United States
TA  - J Clin Rheumatol
JT  - Journal of clinical rheumatology : practical reports on rheumatic & 
      musculoskeletal diseases
JID - 9518034
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Adult
MH  - *Agammaglobulinemia
MH  - Aged
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - *COVID-19
MH  - Female
MH  - *Granulomatosis with Polyangiitis
MH  - Humans
MH  - Immunoglobulin G
MH  - Male
MH  - Middle Aged
MH  - Pandemics
MH  - Prognosis
MH  - Retrospective Studies
MH  - Tertiary Care Centers
PMC - PMC9422241
COIS- The authors declare no conflict of interest.
EDAT- 2022/05/26 06:00
MHDA- 2022/08/31 06:00
PMCR- 2022/05/25
CRDT- 2022/05/25 10:43
PHST- 2022/05/26 06:00 [pubmed]
PHST- 2022/08/31 06:00 [medline]
PHST- 2022/05/25 10:43 [entrez]
PHST- 2022/05/25 00:00 [pmc-release]
AID - 00124743-202209000-00003 [pii]
AID - JCR_220152 [pii]
AID - 10.1097/RHU.0000000000001855 [doi]
PST - ppublish
SO  - J Clin Rheumatol. 2022 Sep 1;28(6):300-304. doi: 10.1097/RHU.0000000000001855. 
      Epub 2022 May 25.