PMID- 35613665
OWN - NLM
STAT- MEDLINE
DCOM- 20220620
LR  - 20220906
IS  - 1873-4596 (Electronic)
IS  - 0891-5849 (Linking)
VI  - 187
DP  - 2022 Jul
TI  - Protective actions of nuclear factor erythroid 2-related factor 2 (NRF2) and 
      downstream pathways against environmental stressors.
PG  - 72-91
LID - S0891-5849(22)00199-X [pii]
LID - 10.1016/j.freeradbiomed.2022.05.016 [doi]
AB  - Environmental risk factors, including noise, air pollution, chemical agents, 
      ultraviolet radiation (UVR) and mental stress have a considerable impact on human 
      health. Oxidative stress and inflammation are key players in molecular 
      pathomechanisms of environmental pollution and risk factors. In this review, we 
      delineate the impact of environmental risk factors and the protective actions of 
      the nuclear factor erythroid 2-related factor 2 (NRF2) in connection to oxidative 
      stress and inflammation. We focus on well-established studies that demonstrate 
      the protective actions of NRF2 and its downstream pathways against different 
      environmental stressors. State-of-the-art mechanistic considerations on NRF2 
      signaling are discussed in detail, e.g. classical concepts like KEAP1 
      oxidation/electrophilic modification, NRF2 ubiquitination and degradation. 
      Specific focus is also laid on NRF2-dependent heme oxygenase-1 induction with 
      detailed presentation of the protective down-stream pathways of heme oxygenase-1, 
      including interaction with BACH1 system. The significant impact of all 
      environmental stressors on the circadian rhythm and the interactions of NRF2 with 
      the circadian clock will also be considered here. A broad range of NRF2 
      activators is discussed in relation to environmental stressor-induced health side 
      effects, thereby suggesting promising new mitigation strategies (e.g. by 
      nutraceuticals) to fight the negative effects of the environment on our health.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Bayo Jimenez, Maria Teresa
AU  - Bayo Jimenez MT
AD  - Department of Cardiology, Cardiology I, University Medical Center of the Johannes 
      Gutenberg-University, Langenbeckstrasse 1, 55131, Mainz, Germany.
FAU - Frenis, Katie
AU  - Frenis K
AD  - Department of Hematology and Oncology, Boston Children's Hospital and Harvard 
      Medical School, 300 Longwood Ave, Boston, MA, 02115, USA.
FAU - Hahad, Omar
AU  - Hahad O
AD  - Department of Cardiology, Cardiology I, University Medical Center of the Johannes 
      Gutenberg-University, Langenbeckstrasse 1, 55131, Mainz, Germany; German Center 
      for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany; 
      Leibniz Insitute for Resilience Research (LIR), Mainz, Germany.
FAU - Steven, Sebastian
AU  - Steven S
AD  - Department of Cardiology, Cardiology I, University Medical Center of the Johannes 
      Gutenberg-University, Langenbeckstrasse 1, 55131, Mainz, Germany.
FAU - Cohen, Guy
AU  - Cohen G
AD  - The Skin Research Institute, The Dead Sea and Arava Science Center, Masada, 
      86910, Israel; Ben Gurion University of the Negev, Eilat Campus, Eilat, 8855630, 
      Israel.
FAU - Cuadrado, Antonio
AU  - Cuadrado A
AD  - Departamento de Bioquimica, Facultad de Medicina, Centro de Investigacion 
      Biomedica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de 
      Investigacion Sanitaria La Paz (IdiPaz), Instituto de Investigaciones Biomedicas 
      'Alberto Sols' UAM-CSIC, Universidad Autonoma de Madrid, Madrid, Spain.
FAU - Munzel, Thomas
AU  - Munzel T
AD  - Department of Cardiology, Cardiology I, University Medical Center of the Johannes 
      Gutenberg-University, Langenbeckstrasse 1, 55131, Mainz, Germany; German Center 
      for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany. 
      Electronic address: tmuenzel@uni-mainz.de.
FAU - Daiber, Andreas
AU  - Daiber A
AD  - Department of Cardiology, Cardiology I, University Medical Center of the Johannes 
      Gutenberg-University, Langenbeckstrasse 1, 55131, Mainz, Germany; German Center 
      for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany. 
      Electronic address: daiber@uni-mainz.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220522
PL  - United States
TA  - Free Radic Biol Med
JT  - Free radical biology & medicine
JID - 8709159
RN  - 0 (Kelch-Like ECH-Associated Protein 1)
RN  - 0 (NF-E2-Related Factor 2)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
SB  - IM
MH  - *Heme Oxygenase-1/genetics/metabolism
MH  - Humans
MH  - Inflammation/chemically induced
MH  - Kelch-Like ECH-Associated Protein 1/genetics/metabolism
MH  - *NF-E2-Related Factor 2/genetics/metabolism
MH  - Oxidative Stress
MH  - Ultraviolet Rays
OTO - NOTNLM
OT  - Air pollution
OT  - Cardiovascular risk
OT  - Environmental risk factors
OT  - Inflammation
OT  - NRF2
OT  - Oxidative stress
OT  - Traffic noise exposure
EDAT- 2022/05/26 06:00
MHDA- 2022/06/22 06:00
CRDT- 2022/05/25 19:23
PHST- 2022/03/13 00:00 [received]
PHST- 2022/04/23 00:00 [revised]
PHST- 2022/05/19 00:00 [accepted]
PHST- 2022/05/26 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2022/05/25 19:23 [entrez]
AID - S0891-5849(22)00199-X [pii]
AID - 10.1016/j.freeradbiomed.2022.05.016 [doi]
PST - ppublish
SO  - Free Radic Biol Med. 2022 Jul;187:72-91. doi: 
      10.1016/j.freeradbiomed.2022.05.016. Epub 2022 May 22.