PMID- 35613677
OWN - NLM
STAT- MEDLINE
DCOM- 20220614
LR  - 20220614
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 212
DP  - 2022 Jul 1
TI  - A review on enzyme complexes of electron transport chain from Mycobacterium 
      tuberculosis as promising drug targets.
PG  - 474-494
LID - S0141-8130(22)01098-4 [pii]
LID - 10.1016/j.ijbiomac.2022.05.124 [doi]
AB  - Energy metabolism is a universal process occurring in all life forms. In 
      Mycobacterium tuberculosis (Mtb), energy production is carried out in two 
      possible ways, oxidative phosphorylation (OxPhos) and substrate-level 
      phosphorylation. Mtb is an obligate aerobic bacterium, making it dependent on 
      OxPhos for ATP synthesis and growth. Mtb inhabits varied micro-niches during the 
      infection cycle, outside and within the host cells, which alters its primary 
      metabolic pathways during the pathogenesis. In this review, we discuss cellular 
      respiration in the context of the mechanism and structural importance of the 
      proteins and enzyme complexes involved. These protein-protein complexes have been 
      proven to be essential for Mtb virulence as they aid the bacteria's survival 
      during aerobic and hypoxic conditions. ATP synthase, a crucial component of the 
      electron transport chain, has been in the limelight, as a prominent drug target 
      against tuberculosis. Likewise, in this review, we have explored other 
      protein-protein complexes of the OxPhos pathway, their functional essentiality, 
      and their mechanism in Mtb's diverse lifecycle. The review summarises crucial 
      target proteins and reported inhibitors of the electron transport chain pathway 
      of Mtb.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Anand, Pragya
AU  - Anand P
AD  - Department of Biotechnology, School of Life Sciences, Babasaheb Bhimrao Ambedkar 
      University, Vidya Vihar, Lucknow, Uttar Pradesh 226025, India.
FAU - Akhter, Yusuf
AU  - Akhter Y
AD  - Department of Biotechnology, School of Life Sciences, Babasaheb Bhimrao Ambedkar 
      University, Vidya Vihar, Lucknow, Uttar Pradesh 226025, India. Electronic 
      address: yusuf@daad-alumni.de.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220522
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Multienzyme Complexes)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
MH  - Adenosine Triphosphate/metabolism
MH  - Electron Transport
MH  - Humans
MH  - Multienzyme Complexes/metabolism
MH  - *Mycobacterium tuberculosis
MH  - *Tuberculosis/microbiology
OTO - NOTNLM
OT  - ATP synthase
OT  - Cytochrome bd oxidase
OT  - Electron transport chain (ETC)
OT  - Inhibitors
OT  - Menaquinone
OT  - Mycobacterium
OT  - NADH dehydrogenase type II
OT  - Succinate dehydrogenase
EDAT- 2022/05/26 06:00
MHDA- 2022/06/15 06:00
CRDT- 2022/05/25 19:23
PHST- 2022/02/21 00:00 [received]
PHST- 2022/05/05 00:00 [revised]
PHST- 2022/05/17 00:00 [accepted]
PHST- 2022/05/26 06:00 [pubmed]
PHST- 2022/06/15 06:00 [medline]
PHST- 2022/05/25 19:23 [entrez]
AID - S0141-8130(22)01098-4 [pii]
AID - 10.1016/j.ijbiomac.2022.05.124 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2022 Jul 1;212:474-494. doi: 10.1016/j.ijbiomac.2022.05.124. 
      Epub 2022 May 22.