PMID- 35614002
OWN - NLM
STAT- MEDLINE
DCOM- 20221101
LR  - 20221228
IS  - 1878-3562 (Electronic)
IS  - 1590-8658 (Linking)
VI  - 54
IP  - 11
DP  - 2022 Nov
TI  - Safety of a novel 1L-polyethylene glycol-ascorbate solution for colonoscopy 
      cleansing (REAL Study).
PG  - 1508-1512
LID - S1590-8658(22)00260-2 [pii]
LID - 10.1016/j.dld.2022.04.014 [doi]
AB  - BACKGROUND AND AIM: Very low-volume bowel preparation (BP) for colonoscopy with 
      1-liter polyethylene glycol plus ascorbate (1L-PEG-Asc) has displayed high 
      tolerability and quality of bowel cleansing. Concerns have been raised regarding 
      its safety. We aimed to evaluate the incidence of adverse events (AEs) following 
      BP with 1L-PEG-Asc or 2L-PEG-Asc. PATIENTS AND METHODS: From January 2019 to 
      September 2020, data from all consecutive adult outpatients who underwent 
      colonoscopy in Our Unit were collected. AEs were assessed by reviewing the 
      clinical and laboratory data of patients who attended the Emergency Department 
      (ED) of Modena District Hospitals in the 7 days following the colonoscopy, and 
      were classified as "BP-related" or "BP-unrelated". RESULTS: During the study, 
      4069 (68.03%) and 1912 (31.97%) patients underwent colonoscopy after taking 
      2L-PEG-Asc or 1L-PEG-Asc, respectively. Regarding AEs, 77 (1.29%) patients 
      attended ED, 53 (53/4069, 1.30%) and 24 (24/1912, 1.25%) after taking 2L-PEG-Asc 
      and 1L-PEG-Asc. BP-related AEs were observed in 5 (5/4069, 0.12%) and 4 (4/1912, 
      0.21%) patients, respectively. The most frequent BP-related AEs were 
      tachyarrhythmias (6/5981, 0.10%). CONCLUSION: The incidence rate of clinically 
      relevant BP-related AEs is extremely low. This strongly suggests that 1L-PEG-Asc 
      colonoscopy BP is as safe as 2L-PEG-Asc BP in a real-life clinical setting of 
      unselected patients.
CI  - Copyright (c) 2022. Published by Elsevier Ltd.
FAU - Manno, Mauro
AU  - Manno M
AD  - Gastroenterology and Digestive Endoscopy Unit, AUSL Modena, Italy.
FAU - Biancheri, Paolo
AU  - Biancheri P
AD  - Gastroenterology and Digestive Endoscopy Unit, AUSL Modena, Italy.
FAU - Bonura, Giuliano Francesco
AU  - Bonura GF
AD  - Gastroenterology and Digestive Endoscopy Unit, AUSL Modena, Italy.
FAU - Gabbani, Tommaso
AU  - Gabbani T
AD  - Gastroenterology and Digestive Endoscopy Unit, AUSL Modena, Italy.
FAU - Rainer, Joachim
AU  - Rainer J
AD  - Gastroenterology and Digestive Endoscopy Unit, AUSL Modena, Italy.
FAU - Curatolo, Angela
AU  - Curatolo A
AD  - Gastroenterology and Digestive Endoscopy Unit, AUSL Modena, Italy.
FAU - Deiana, Simona
AU  - Deiana S
AD  - Gastroenterology and Digestive Endoscopy Unit, AUSL Modena, Italy.
FAU - Impellizzeri, Giovanna
AU  - Impellizzeri G
AD  - Gastroenterology and Digestive Endoscopy Unit, AUSL Modena, Italy.
FAU - Ottaviani, Laura
AU  - Ottaviani L
AD  - Gastroenterology and Digestive Endoscopy Unit, AUSL Modena, Italy.
FAU - Hassan, Cesare
AU  - Hassan C
AD  - Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, 
      Italy.
FAU - Repici, Alessandro
AU  - Repici A
AD  - Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, 
      Italy.
FAU - Soriani, Paola
AU  - Soriani P
AD  - Gastroenterology and Digestive Endoscopy Unit, AUSL Modena, Italy. Electronic 
      address: paola.soriani@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20220522
PL  - Netherlands
TA  - Dig Liver Dis
JT  - Digestive and liver disease : official journal of the Italian Society of 
      Gastroenterology and the Italian Association for the Study of the Liver
JID - 100958385
RN  - 0 (Cathartics)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 0 (Laxatives)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Cathartics/adverse effects
MH  - *Polyethylene Glycols/adverse effects
MH  - Colonoscopy
MH  - Laxatives
MH  - Ascorbic Acid/adverse effects
OTO - NOTNLM
OT  - Adverse event
OT  - Bowel preparation
OT  - Low volume
OT  - Safety
OT  - Very low-volume
EDAT- 2022/05/26 06:00
MHDA- 2022/11/02 06:00
CRDT- 2022/05/25 22:04
PHST- 2021/12/27 00:00 [received]
PHST- 2022/04/20 00:00 [revised]
PHST- 2022/04/21 00:00 [accepted]
PHST- 2022/05/26 06:00 [pubmed]
PHST- 2022/11/02 06:00 [medline]
PHST- 2022/05/25 22:04 [entrez]
AID - S1590-8658(22)00260-2 [pii]
AID - 10.1016/j.dld.2022.04.014 [doi]
PST - ppublish
SO  - Dig Liver Dis. 2022 Nov;54(11):1508-1512. doi: 10.1016/j.dld.2022.04.014. Epub 
      2022 May 22.