PMID- 35614838
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220526
IS  - 2161-1653 (Electronic)
IS  - 2161-1653 (Linking)
VI  - 4
IP  - 11
DP  - 2015 Nov 17
TI  - Effect of Micellization on the Thermoresponsive Behavior of Polymeric Assemblies.
PG  - 1210-1214
LID - 10.1021/acsmacrolett.5b00551 [doi]
AB  - The chain density of polymer micelles, dictated by their aggregation number 
      (N(agg)), is an often overlooked parameter that governs the macroscopic behavior 
      of responsive assemblies. Using a combination of variable-temperature light 
      scattering, turbidimetry, and microcalorimetry experiments, the cloud point and 
      thermal collapse of micellar poly(N-isopropylacrylamide) (pNIPAM) corona chains 
      at lower temperatures than the cloud point were found to be largely independent 
      of the micelle's N(agg). By controlling the core composition, the degree of 
      hysteresis associated with the thermal transition was found to increase as a 
      function of core hydrophobicity. We performed this study on well-characterized 
      micelles with tunable N(agg) values, composed of a thermoresponsive corona 
      (pNIPAM) and a nonresponsive core block poly(n-butyl 
      acrylate-co-N,N-dimethylacrylamide) (p(nBA-co-DMA)), which were synthesized using 
      reversible addition-fragmentation chain transfer (RAFT) polymerization. This 
      allowed for a distinction to be made between thermoresponsive behavior at both 
      the molecular and macroscopic level. The study of the subtle differences between 
      these behaviors was made possible using a combination of complementary 
      techniques. These results highlight the critical need for consideration of the 
      effect that self-assembly plays on the responsive behavior of polymer chains when 
      compared with free unimers in solution.
FAU - Blackman, Lewis D
AU  - Blackman LD
AD  - University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K.
FAU - Wright, Daniel B
AU  - Wright DB
AD  - University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K.
FAU - Robin, Mathew P
AU  - Robin MP
AD  - University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K.
FAU - Gibson, Matthew I
AU  - Gibson MI
AD  - University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K.
FAU - O'Reilly, Rachel K
AU  - O'Reilly RK
AD  - University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K.
LA  - eng
PT  - Journal Article
DEP - 20151019
PL  - United States
TA  - ACS Macro Lett
JT  - ACS macro letters
JID - 101574672
SB  - IM
EDAT- 2015/11/17 00:00
MHDA- 2015/11/17 00:01
CRDT- 2022/05/26 01:25
PHST- 2022/05/26 01:25 [entrez]
PHST- 2015/11/17 00:00 [pubmed]
PHST- 2015/11/17 00:01 [medline]
AID - 10.1021/acsmacrolett.5b00551 [doi]
PST - ppublish
SO  - ACS Macro Lett. 2015 Nov 17;4(11):1210-1214. doi: 10.1021/acsmacrolett.5b00551. 
      Epub 2015 Oct 19.