PMID- 35615307
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2296-2646 (Print)
IS  - 2296-2646 (Electronic)
IS  - 2296-2646 (Linking)
VI  - 10
DP  - 2022
TI  - Design of Ascorbic Acid Eutectic Mixtures With Sugars to Inhibit Oxidative 
      Degradation.
PG  - 754269
LID - 10.3389/fchem.2022.754269 [doi]
LID - 754269
AB  - L-Ascorbic acid (ASC), commonly known as vitamin C, acts as an anti-oxidant in 
      the biological system. It is extensively used as an excipient in pharmaceutical 
      industry, food supplements in fruit juices, and food materials due to its free 
      radicals scavenging activity. Main drawback of ASC is its poor aqueous stability 
      owing to the presence of lactone moiety that is easily oxidized to 
      dehydroascorbic acid and further degraded. To improve aqueous stability and 
      inhibit oxidative degradation, ASC was co-crystallized to constitute binary 
      eutectic compositions with mono and di-saccharides such as glucose, sucrose, 
      lactose, and mannitol. The eutectics were confirmed by their (single) lower 
      melting endotherm compared to ASC and sugars, although Powder X-ray diffraction 
      (PXRD) and Fourier transform Infrared spectroscopy (FT-IR) data confirmed the 
      characteristics of their physical mixture. Scanning electron microscope (SEM) 
      images of the binary eutectics confirmed their irregular morphology. The ASC 
      eutectics exhibited improved shelf-life by 2-5-fold in weakly acidic (pH 5) and 
      neutral (pH 7) aqueous buffer medium, whereas the eutectic with glucose enhanced 
      shelf-life only by 1.1-1.2-fold in acidic medium (pH 3.3 and 4). Notably, 
      stabilizing effect of the sugar eutectics decreased with increasing acidity of 
      the medium. In addition, higher binding energy of the disaccharide eutectics 
      partially supports the aqueous stability order of ASC in the neutral pH medium 
      due to more number of non-bonded interactions than that of monosaccharides.
CI  - Copyright (c) 2022 Palanisamy, Sanphui, Palanisamy, Prakash and Bansal.
FAU - Palanisamy, Vasanthi
AU  - Palanisamy V
AD  - Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of 
      Science and Technology, Chennai, India.
FAU - Sanphui, Palash
AU  - Sanphui P
AD  - Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of 
      Science and Technology, Chennai, India.
FAU - Palanisamy, Kandhan
AU  - Palanisamy K
AD  - Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of 
      Science and Technology, Chennai, India.
FAU - Prakash, Muthuramalingam
AU  - Prakash M
AD  - Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of 
      Science and Technology, Chennai, India.
FAU - Bansal, Arvind Kumar
AU  - Bansal AK
AD  - Department of Pharmaceutics, National Institute of Pharmaceutical Education and 
      Research (NIPER), Mohali, India.
LA  - eng
PT  - Journal Article
DEP - 20220509
PL  - Switzerland
TA  - Front Chem
JT  - Frontiers in chemistry
JID - 101627988
PMC - PMC9125031
OTO - NOTNLM
OT  - ascorbic acid
OT  - binding energy
OT  - eutectics
OT  - lamellar microstructure
OT  - shelf-life
OT  - sugar
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/05/27 06:00
MHDA- 2022/05/27 06:01
PMCR- 2022/01/01
CRDT- 2022/05/26 02:21
PHST- 2021/08/06 00:00 [received]
PHST- 2022/03/25 00:00 [accepted]
PHST- 2022/05/26 02:21 [entrez]
PHST- 2022/05/27 06:00 [pubmed]
PHST- 2022/05/27 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 754269 [pii]
AID - 10.3389/fchem.2022.754269 [doi]
PST - epublish
SO  - Front Chem. 2022 May 9;10:754269. doi: 10.3389/fchem.2022.754269. eCollection 
      2022.