PMID- 35615472
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231101
IS  - 2296-4185 (Print)
IS  - 2296-4185 (Electronic)
IS  - 2296-4185 (Linking)
VI  - 10
DP  - 2022
TI  - Engineering Multifunctional Hydrogel With Osteogenic Capacity for Critical-Size 
      Segmental Bone Defect Repair.
PG  - 899457
LID - 10.3389/fbioe.2022.899457 [doi]
LID - 899457
AB  - Treating critical-size segmental bone defects is an arduous challenge in clinical 
      work. Preparation of bone graft substitutes with notable osteoinductive 
      properties is a feasible strategy for critical-size bone defects. Herein, a 
      biocompatible hydrogel was designed by dynamic supramolecular assembly of 
      polyvinyl alcohol (PVA), sodium tetraborate (Na(2)B(4)O(7)), and tetraethyl 
      orthosilicate (TEOS). The characteristics of the supramolecular hydrogel were 
      evaluated by rheological analysis, swelling ratio, degradation experiments, and 
      scanning electron microscopy (SEM). In in vitro experiments, this TEOS-hydrogel 
      had self-healing property, low swelling rate, degradability, good 
      biocompatibility, and induced osteogenic differentiation of bone marrow 
      mesenchymal stem cells (BMSCs) by upregulating the expression of Runx-2, Col-1, 
      OCN, and osteopontin (OPN). In segmental bone defect rabbit models, the 
      TEOS-containing hydrogel accelerated bone regeneration, thus restoring the 
      continuity of bone and recanalization of the medullary cavity. The abovementioned 
      results demonstrated that this TEOS-hydrogel has the potential to realize bone 
      healing in critical-size segmental bone defects.
CI  - Copyright (c) 2022 Zheng, Zhong, Cheng, Li, Zeng, Chen, Zou, Liu and Sun.
FAU - Zheng, Shaowei
AU  - Zheng S
AD  - Department of Orthopaedic, Huizhou First Hospital, Guangdong Medical University, 
      Huizhou, China.
AD  - Department of Orthopaedic Surgery, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Zhong, Haobo
AU  - Zhong H
AD  - Department of Orthopaedic, Huizhou First Hospital, Guangdong Medical University, 
      Huizhou, China.
FAU - Cheng, Hao
AU  - Cheng H
AD  - Department of Orthopaedic Surgery, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Li, Xu
AU  - Li X
AD  - Department of Orthopaedic, Huizhou First Hospital, Guangdong Medical University, 
      Huizhou, China.
FAU - Zeng, Guowei
AU  - Zeng G
AD  - Graduate School, Guangdong Medical University, Zhanjiang, China.
FAU - Chen, Tianyu
AU  - Chen T
AD  - Department of Orthopedics, The Third Affiliated Hospital of Southern Medical 
      University, Guangzhou, China.
FAU - Zou, Yucong
AU  - Zou Y
AD  - Department of Orthopedics, The Third Affiliated Hospital of Southern Medical 
      University, Guangzhou, China.
FAU - Liu, Weile
AU  - Liu W
AD  - Department of Orthopaedic, Huizhou First Hospital, Guangdong Medical University, 
      Huizhou, China.
FAU - Sun, Chunhan
AU  - Sun C
AD  - Department of Orthopaedic, Huizhou First Hospital, Guangdong Medical University, 
      Huizhou, China.
LA  - eng
PT  - Journal Article
DEP - 20220509
PL  - Switzerland
TA  - Front Bioeng Biotechnol
JT  - Frontiers in bioengineering and biotechnology
JID - 101632513
PMC - PMC9124794
OTO - NOTNLM
OT  - BMSCs
OT  - bone regeneration
OT  - critical bone defect
OT  - hydrogel
OT  - osteogenic differentiation
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/05/27 06:00
MHDA- 2022/05/27 06:01
PMCR- 2022/01/01
CRDT- 2022/05/26 02:25
PHST- 2022/03/18 00:00 [received]
PHST- 2022/04/01 00:00 [accepted]
PHST- 2022/05/26 02:25 [entrez]
PHST- 2022/05/27 06:00 [pubmed]
PHST- 2022/05/27 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 899457 [pii]
AID - 10.3389/fbioe.2022.899457 [doi]
PST - epublish
SO  - Front Bioeng Biotechnol. 2022 May 9;10:899457. doi: 10.3389/fbioe.2022.899457. 
      eCollection 2022.